中药黄酮类化合物改善非酒精性脂肪肝的作用机制研究进展

doi:10.16431/j.cnki.1671-7236.2025.09.043

Abstract

Abstract: Nonalcoholic fatty liver disease (NAFLD) is relatively common in clinical practice.It is a syndrome caused by nonalcoholic factors leading to secondary metabolic dysfunction of liver.Its main characteristics are steatosis of liver cells and excessive accumulation of fatin the liver.With the continuous improvement of people’s living standards,NAFLD caused by excessive fat intake has become widely prevalent among humans and pets,and has become one of the most common chronic liver diseases globally.NAFLD is a key factor leading to the increasing incidence and mortality of liver and metabolic diseases.At present,the treatment for NAFLD mainly focuses on alleviating symptomos,and it is urgent to explore more effective treatment strategies.Flavonoids from traditional Chinese medicine，with multi-component combinations,multi-target effects and diverse mechanisms,have shown great potential in the intervention of NAFLD.The author reviewed the pathways by which flavonoids improve NAFLD,such as improving insulin resistance,relieving oxidative stress,inhibiting inflammatory responses,anti-ferroptosis,anti-apoptosis,regulating autophagy levels and regulating intestinal flora,etc.Meanwhile,the molecular targets/signaling pathways of flavonoids in improving NAFLD were summarized,so as to provide references for the basic research,drug development and clinical application of flavonoids in the intervention of NAFLD.

Key words: traditional Chinese medicine; flavonoids; nonalcoholic fatty liver disease (NAFLD); mechanism

CLC Number:

S859.7

LI Xiaoxiao, KE Jincheng, LI Li. Research Progress on the Mechanism of Traditional Chinese Medicine Flavonoids in Improving Nonalcoholic Fatty Liver Disease[J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(9): 4484-4496.

References

[1] HUANG X,YU R,TAN X,et al.Comparison of NAFLD,MAFLD,and MASLD prevalence and clinical characteristics in Asia adults[J].Journal of Clinical and Experimental Hepatology,2025，15(1):102420.
[2] MAKRI E,GOULAS A,POLYZOS S A.Epidemiology,pathogenesis,diagnosis and emerging treatment of nonalcoholic fatty liver disease[J].Archives of Medical Research,2021，52(1):25-37.
[3] HUANG D Q,EL-SERAG H B,LOOMBA R.Global epidemiology of NAFLD-related HCC:Trends,predictions,risk factors and prevention[J].Nature Reviews.Gastroenterology & Hepatology,2021，18(4):223-238.
[4] 黄云龙.植物黄酮类化合物研究进展[J].中国果菜,2025,45(1):71-79. HUANG Y L.Advances in research on flavonoid compounds in plants[J].China Fruit & Vegetable,2025,45(1):71-79.(in Chinese)
[5] BELL W,JENNINGS A,THOMPSON A S,et al.A flavonoid-rich diet is associated with lower risk and improved imaging biomarkers of nonalcoholic fatty liver disease:A prospective cohort study[J].The American Journal of Clinical Nutrition,2024，120(6):1325-1334.
[6] ALZOUGHOOL F,ABDELQADER R,ABUMWEIS S,et al.Evaluation of adropin level and insulin resistance in non-alcoholic fatty liver patients:A Meta-analysis of studies[J].European Review for Medical and Pharmacological Sciences,2024，28(21):4507-4514.
[7] ALLISTER E M,MULVIHILL E E,BARRETT P H,et al.Inhibition of apoB secretion from HepG2 cells by insulin is amplified by naringenin,independent of the insulin[J].Journal of Lipid Research,2008,49(10):2218-2229.
[8] 李丽,周焕第,罗泽萍,等.瑶药地菍对四氯化碳致小鼠急性肝损伤的保护作用[J].时珍国医国药,2014,25(4):819-820. LI L,ZHOU H D,LUO Z P,et al.The protective effect of Yao medicine Melastoma dodecandrum Lour.on carbon tetrachloride-induced acute liver injury in mice[J].Lishizhen Medicine and Materia Medica Research,2014,25(4):819-820.(in Chinese)
[9] 周敬凯,黄馨慧,刘舒凌,等.地菍总黄酮对胰岛素抵抗小鼠的干预作用及机制研究[J].中国畜牧兽医,2020,47(9):3030-3037. ZHOU J K,HUANG X H,LIU S L,et al.Study on the intervention effect and mechanism on insulin resistant mice of total flavone from Melastoma dodecandrum Lour.[J].China Animal Husbandry & Veterinary Medicine,2020,47(9):3030-3037.(in Chinese)
[10] MUNAKARMI S,GURAU Y,SHRESTHA J,et al.Trans-chalcone ameliorates CCl₄-induced acute liver injury by suppressing endoplasmic reticulum stress,oxidative stress and inflammation[J].Pathology,Research and Practice,2024，263:155663.
[11] WU S,GUO N,XU H,et al.Caveolin-1 ameliorates hepatic injury in non-alcoholic fatty liver disease by inhibiting ferroptosis via the NOX4/ROS/GPX4 pathway[J].Biochemical Pharmacology,2024，230(Pt 2):116594.
[12] 陈璇.黄酮类化合物(槲皮素、木犀草素)与类胡萝卜素(番茄红素、叶黄素)协同抗氧化作用及分子机制[D].南昌：南昌大学,2022. CHEN X.Synergistic antioxidant effects and molecular mechanisms of flavonoids (quercetin,luteolin) and caroten (lycopene,lutein)[D].Nanchang:Nanchang University,2022.(in Chinese)
[13] 马立光.大豆异黄酮对非酒精性脂肪肝模型大鼠的干预作用[D].延吉：延边大学，2014. MA L G.The interventional effect of soy isoflavones on the non-alcoholic fatty liver model rats[D].Yanji:Yanbian University,2014.(in Chinese)
[14] 宋敏,于季军,杨丹彤,等.菟丝子黄酮对慢性肝损伤保护作用的研究[J].湖南农业科学,2010,23:151-153. SONG M,YU J J,YANG D T,et al.Protective effects of Cuscuta chinensis flavonoids on chronic liver damage[J].Hunan Agricultural Sciences,2010，23:151-153.(in Chinese)
[15] 王蒙蒙,乔雪,方琼莲,等.滇黄芩总黄酮不同极性萃取部位对非酒精性脂肪肝模型大鼠的改善作用研究[J].中国药房,2022,33(11):1338-1342. WANG M M,QIAO X,FANG Q L,et al.Study on improvement effects of different polar parts from total flavonoids of Scutellaria amoena on non-alcoholic fatty liver model rats[J].China Pharmacy,2022，33(11):1338-1342.(in Chinese)
[16] ZHAO L，YANG L，AHMAD K.Kaempferol ameliorates palmitate-induced lipid accumulation in HepG2 cells through activation of the Nrf2 signaling pathway[J].Human & Experimental Toxicology,2023，42:9603271221146780.
[17] LI N，HAO L,LI S，et al.The NRF-2/HO-1 signaling pathway:A promising therapeutic target for metabolic dysfunction-associated steatotic liver disease[J].Journal of Inflammation Research,2024，17:8061-8083.
[18] 施政.胡柚皮黄酮调控Nrf2-ARE信号通路治疗非酒精性脂肪性肝病的作用及其机制研究[D].杭州：浙江中医药大学，2023. SHI Z.Effects and mechanisms of Huyou peel flavonoids on Nrf2-ARE signaling pathway in nonalcoholic fatty liver disease[D].Hangzhou:Zhejiang Chinese Medical University,2023.(in Chinese)
[19] 付海洋,姜良勇,齐亚军,等.芹菜素药理作用的研究进展[J].国际药学研究杂志,2020,47(10):787-792. FU H Y,JIANG L Y,QI Y J,et al.Pharmacological effects of apigenin:Research advances[J].Journal of International Pharmaceutical Research,2020,47(10):787-792.(in Chinese)
[20] 周飞飞.芹菜素通过激活Nrf2改善非酒精性脂肪肝的功能及机制研究[D].南京：南京大学，2016. ZHOU F F.Apigenin improves NAFLD by activating Nrf2[D].Nanjing:Nanjing University,2016.(in Chinese)
[21] WU J,HUANG H，GONG L,et al.A flavonoid glycoside compound from Siraitia grosvenorii with anti-inflammatory and hepatoprotective effects in vitro[J].Biomolecules,2024，14(4):450.
[22] CHENG Y,FENG S，SHENG C，et al.Nobiletin from citrus peel:A promising therapeutic agent for liver disease-pharmacological characteristics,mechanisms,and potential applications[J].Frontiers in Pharmacology,2024，15:1354809.
[23] 陈芝芸,严茂祥,叶蕾,等.山楂叶总黄酮对非酒精性脂肪性肝炎大鼠肝脏PPARs表达的影响[J].中华中医药杂志,2012,27(1):81-84. CHEN Z Y,YAN M X,YE L,et al.Effect of TFHL on the expressions of PPARs in the livers of rats with nonalcoho1ic steatohepatitis[J].China Journal of Traditional Chinese Medicine and Pharmacy,2012,27(1):81-84.(in Chinese)
[24] 唐雨菲,周敬凯,莫烨云,等.地菍总黄酮对高脂饮食诱导非酒精性脂肪肝大鼠脂代谢的影响[J].中国畜牧兽医, 2023，50(8):3438-3447. TANG Y F,ZHOU J K,MO Y Y,et al.Effect of total flavonoids from Melastoma dodecandrum Lour.on lipid metabolism of nonalcoholic fatty liver rats induced by high-fat diet[J].China Animal Husbandry & Veterinary Medicine, 2023，50(8):3438-3447.(in Chinese)
[25] 赵文红,邓泽元,范青生,等.淫羊藿总黄酮体外抗氧化实验[J].南昌大学学报(理科版),2009，33(1):53-55. ZHAO W H,DENG Z Y,FAN Q S,et al.Anti-oxidation on total flavones of epimedium in vitro[J].Journal of Nanchang University (Natural Science),2009，33(1):53-55.(in Chinese)
[26] 周峰峰.淫羊藿总黄酮抑制氧化应激反应治疗NAFLD的相关机制研究[D].上海：上海中医药大学,2020. ZHOU F F.The study on the mechanism of epimedium total flavonoids inhibiting oxidative stress response in the treatment of NAFLD[D].Shanghai:Shanghai University of Traditional Chinese Medicine,2020.(in Chinese)
[27] 王齐.构树叶总黄酮对小鼠非酒精性脂肪肝病的治疗作用研究[D].长春：吉林大学,2021. WANG Q.Study on the therapeutic effect of total flavonoids from Ginkgo biloba leaves on non-alcoholic fatty[D].Changchun:Jilin University,2021.(in Chinese)
[28] LEOPOLD M,MASS-SANCHEZ P B,KRIZANAC M,et al.How the liver transcriptome and lipid composition influence the progression of nonalcoholic fatty liver disease to hepatocellular carcinoma in a murine model[J].Biochimica et Biophysica Acta.Molecular and Cell Biology of Lipids,2025，1870(1):159574.
[29] 王海燕,张宇新,朱丽,等.miR-122-5p、miR-143-3p及炎症因子IL-6、IL-10在双酚A和高脂饮食诱导的小鼠非酒精性脂肪性肝病中的表达及意义[J].安徽医科大学学报,2024，59(10):1769-1776. WANG H Y,ZHANG Y X,ZHU L,et al.Expression and significance of miR-122-5p,miR-143-3p and inflammatory factors IL-6 and IL-10 in mice with nonalcoholic fatty liver disease induced by bisphenol A and high-fat diet[J].Acta Universitatis Medicinalis Anhui, 2024，59(10):1769-1776.(in Chinese)
[30] 袁凌萍.小心脂肪肝发展成肝硬化[J].人人健康,2024，26:42. YUAN L P.Be cautious about fatty liver developing into cirrhosis[J].Health for Everyone, 2024，26:42.(in Chinese)
[31] CURCI D,STANKOVIC B,KOTUR N,et al.The long non-coding RNA GAS5 contributes to the suppression of inflammatory responses by inhibiting NF-κB activity[J].Frontiers in Pharmacology,2024，15:1448136.
[32] ZHANG Q B,WANG H,XU F,et al.TLR3 activation enhances antitumor effects of sorafenib in hepatocellular carcinoma by activating NK cell functions through ERK and NF-κB pathways[J].Scientific Reports,2024，14(1):26422.
[33] ZHANG J,YUAN Y,GAO X,et al.Scopoletin ameliorates hyperlipidemia and hepatic steatosis via AMPK,Nrf2/HO-1 and NF-κB signaling pathways[J].Biochemical Pharmacology,2025，231:116639.
[34] 李莉,王嘉瑞,王晶,等.淫羊藿的主要化学成分、药理作用研究进展及质量标志物的预测分析[J].中华中医药学刊,2023，41(11):143-151. LI L,WANG J R,WANG J,et al.Research progress on main chemical components and pharmacological effects of Yinyanghuo (Epimedium brevicornu Maxim) and predictive analysis on its quality marker[J].Chinese Archives of Traditional Chinese Medicine, 2023，41(11):143-151.(in Chinese)
[35] 钱圳.淫羊藿苷改善非酒精性脂肪肝的作用和机制研究[D].长春：长春中医药大学,2020. QIAN Z.The study on the effects and mechanisms of icariin in improving non-alcoholic fatty liver disease[D].Changchun:Changchun University of Chinese Medicine,2020.(in Chinese)
[36] 陈佳敏,刘欣,邹玉卿,等.石斛合剂对2型糖尿病合并非酒精性脂肪肝小鼠mTOR-TFEB-NF-κB的调控作用[J].亚太传统医药,2022，18(5):27-31. CHEN J M,LIU X,ZOU Y Q,et al.Study on the mechanism of shhj on type 2 diabetes mellitus complicated with non-alcoholic steatohepatitis based on mTOR-TFEB-NF-κB signal pathway[J].Asia-Pacific Traditional Medicine, 2022，18(5):27-31.(in Chinese)
[37] OSMAN H A,ABUHAMDAH S M A,HASSAN M H,et al.NLRP3 inflammasome pathway involved in the pathogenesis of metabolic associated fatty liver disease[J].Scientific Reports,2024，14(1):19648.
[38] HU H,WANG S,CHEN C.Pathophysiological role and potential drug target of NLRP3 inflammasome in the metabolic disorders[J].Cellular Signalling,2024，122:111320.
[39] 刘学仁.柚皮苷、橙皮苷和新橙皮苷的提取与分析研究[D].黄石：湖北师范大学,2011. LIU X R.The extraction and analysis research of naringin,hesperidin,and neohesperidin[D].Huangshi:Hubei Normal University,2011.(in Chinese)
[40] 陆一慧,黄超原,王恺疌,等.新橙皮苷对非酒精性脂肪性肝炎小鼠NLRP3/NF-κB信号通路的影响[J].时珍国医国药,2024，35(3):602-607. LU Y H,HUANG C Y,WANG K J,et al.Effect of neohesperidin on NLRP3/NF-κB signaling pathway on mice with non-alcoholic steatohepatitis[J].Lishizhen Medicine and Materia Medica Research, 2024，35(3):602-607.(in Chinese)
[41] 李剑波,余陈欢,王志远,等.槲皮素对大鼠非酒精性脂肪肝炎的治疗作用及其机制[J].实验动物与比较医学,2017，37(2):83-88. LI J B,YU C H,WANG Z Y,et al.Therapeutic effects and mechanisms of quercetin on non-alcoholic steatohepatitis in rats[J].Laboratory Animal and Comparative Medicine, 2017，37(2):83-88.(in Chinese)
[42] YUE L,LI N,YE X,et al.Polymethoxylated flavones for modulating signaling pathways in inflammation[J].International Immunopharmacology,2024，143(Pt 3):113522.
[43] 赵格,骆远,李亚平,等.核因子E2相关因子2在运动改善非酒精性脂肪性肝病中的作用[J].生物化学与生物物理进展,2024，51(5):1079-1089. ZHAO G,LUO Y,LI Y P,et al.The role of Nrf2 in exercise improving of NAFLD[J].Progress in Biochemistry and Biophysics,2024，51(5):1079-1089.(in Chinese)
[44] SHRESTHA J,BAEK D J,OH Y S,et al.Protective effect of Cudrania tricuspidata extract against high-fat diet induced nonalcoholic fatty liver disease through Nrf2/HO-1 pathway[J].Molecules (Basel,Switzerland),2021，26(9):2434.
[45] 高艳霞.黄芩苷对高脂饮食诱导的小鼠非酒精性脂肪肝病的改善作用及机制研究[D].太谷：山西农业大学,2023. GAO Y X.The study on the improvement effect and mechanism of baicalin on non-alcoholic fatty liver disease induced by high-fat diet in mice[D].Taigu:Shanxi Agricultural University,2023.(in Chinese)
[46] 王莲,肖继椿,田垚,等.柿叶黄酮通过激活自噬与抗氧化应激协同作用改善NAFLD大鼠肝脏脂肪变性[J].天津医药,2023，51(11):1211-1216. WANG L,XIAO J C,TIAN Y,et al.Study of persimmon leaf flavonoids ameliorates liver steatosis by activating autophagy and antioxidant stress in NAFLD rats[J].Tianjin Medical Journal, 2023，51(11):1211-1216.(in Chinese)
[47] 程佳奇.秦皮苷通过AMPK/Nrf2信号通路及肠道菌群对高脂饮食喂养小鼠非酒精性脂肪肝病的作用机制研究[D].长春：吉林大学,2024. CHENG J Q.The study on the mechanism of action of atractyloside on non-alcoholic fatty liver disease in mice fed a high-fat diet through the AMPK/Nrf2 signaling pathway and gut microbiota[D].Changchun:Jilin University,2024.(in Chinese)
[48] 韦云飞.光果甘草粗提物缓解非酒精性脂肪肝病中脂质积累的作用研究[D].长春：吉林大学,2023. WEI Y F.Study on the effect of crude extract of Glycyrrhiza glabra on alleviating lipid accumulation in non-alcoholic fatty liver disease[D].Changchun:Jilin University,2023.(in Chinese)
[49] 王宁,李京涛,常占杰,等.PI3K/AKt信号通路在胰岛素抵抗所致非酒精性脂肪性肝病中作用机制的研究进展[J].胃肠病学和肝病学杂志,2019，28(11):1308-1311. WANG N,LI J T,CHANG Z J,et al.Research progress of PI3K/Akt signal pathway in non-alcoholic fatty liver disease caused by insulin resistance[J].Chinese Journal of Gastroenterology and Hepatology,2019，28(11):1308-1311.(in Chinese)
[50] 马梦鸽.红花叶总黄酮的制备工艺及保肝作用评价[D].长春：长春中医药大学,2023. MA M G.The preparation technology and evaluation of hepatoprotective effects of safflower leaves total flavonoids[D].Changchun:Changchun University of Chinese Medicine,2023.(in Chinese)
[51] 白鑫,刘珉宇.非酒精性脂肪肝病中上皮-间充质转化过程的研究现状[J].世界临床药物,2024，45(9):980-985. BAI X,LIU M Y.Research status of epithelial-mesenchymal transition in non-alcoholic fatty liver disease[J]. World Clinical Drug, 2024，45(9):980-985.(in Chinese)
[52] 董哲文,兰欢,李婉萤,等.黄酮类物质调控PPAR-γ参与器官纤维化发生机制的研究进展[J].中药药理与临床,2022，38(1):229-233. DONG Z W,LAN H,LI W Y,et al.Research progress on the mechanism of flavonoids regulating PPAR-γ in organ fibrosis[J].Pharmacology and Clinics of Chinese Materia Medica,2022，38(1):229-233.(in Chinese)
[53] 杨婷,顾小义,王蓓茹,等.碱蓬黄酮对四氯化碳诱导的雌性小鼠肝纤维化的保护作用[J].药学研究,2024，43(7):648-652. YANG T,GU X Y,WANG B R,et al.Protective effect of flavonoids from Suaeda glauca on carbon tetrachloride-induced liver fibrosis in female mice[J].Journal of Pharmaceutical Research, 2024，43(7):648-652.(in Chinese)
[54] 梁业飞.荔枝核总黄酮抑制NLRP3炎症小体抗DMN致肝纤维化的机制研究[D].南宁：广西中医药大学,2023. LIANG Y F.Study on the mechanism of litchi kernel total flavonoids inhibiting NLRP3 inflammasome against DMN-induced liver fibrosis[D].Nanning:Guangxi University of Chinese Medicine,2023.(in Chinese)
[55] 杜金辉.花青素通过mmu-circ-0000623调控肝星状细胞自噬通量水平改善小鼠肝纤维化的机制研究[D].贵阳：贵州医科大学,2023. DU J H.The study on the mechanism of improving liver fibrosis in mice by regulating the autophagic flux level of hepatic stellate cells through mmu-circ-0000623 by anthocyanin[D].Guiyang:Guizhou Medical University,2023.(in Chinese)
[56] GE T,WANG Y,HAN Y,et al.Exploring the updated roles of ferroptosis in liver diseases:Mechanisms,regulators,and therapeutic implications[J].Cell Biochemistry and Biophysics,2024.Doi:10.1007/s12013-024-01611-3.Online ahead of print.
[57] SUI Y,GENG X,WANG Z,et al.Targeting the regulation of iron homeostasis as a potential therapeutic strategy for nonalcoholic fatty liver disease[J].Metabolism:Clinical and Experimental,2024，157:155953.
[58] ZHOU Q，MENG Y,LE J,et al.Ferroptosis:Mechanisms and therapeutic targets[J].MedComm,2024，5(12):e70010.
[59] YU Q,SONG L.Unveiling the role of ferroptosis in the progression from NAFLD to NASH:Recent advances in mechanistic understanding[J].Frontiers in Endocrinology,2024，15:1431652.
[60] 张新.铁死亡引发小鼠非酒精性脂肪肝病的分子机制及黄芪甲苷的调控作用研究[D].沈阳：辽宁中医药大学,2022. ZHANG X.Study on the molecular mechanism of ferroptosis-induced non-alcoholic fatty liver disease in mice and the regulatory role of astragaloside[D].Shenyang:Liaoning University of Traditional Chinese Medicine,2022.(in Chinese)
[61] JIANG Z,SUN H,MIAO J,et al.The natural flavone acacetin protects against high-fat diet-induced lipid accumulation in the liver via the endoplasmic reticulum stress/ferroptosis pathway[J].Biochemical and Biophysical Research Communications,2023，640:183-191.
[62] 冼莹莹.葛根素的研究现状和发展方向[J].轻工科技,2023，39(3):9-11. XIAN Y Y.The research status and development direction of puerarin[J].Light Industry Science and Technology, 2023，39(3):9-11.(in Chinese)
[63] YANG M,XIA L,SONG J,et al.Puerarin ameliorates metabolic dysfunction-associated fatty liver disease by inhibiting ferroptosis and inflammation[J].Lipids in Health and Disease,2023，22(1):202.
[64] WANG G,JIANG X,TORABIAN P,et al.Investigating autophagy and intricate cellular mechanisms in hepatocellular carcinoma:Emphasis on cell death mechanism crosstalk[J].Cancer Letters,2024，588:216744.
[65] WANG X,YANG J,YANG W,et al.Multiple roles of p53 in cancer development:Regulation of tumor microenvironment,m⁶A modification and diverse cell death mechanisms[J].Journal of Advanced Research,2024，28:S2090-1232(24)00481-8.
[66] CHEN J,WANG X,XIA T,et al.Molecular mechanisms and therapeutic implications of dihydromyricetin in liver disease[J].Biomedicine & Pharmacotherapy,2021，142:111927.
[67] HERNÁNDEZ-AQUINO E,MURIEL P.Beneficial effects of naringenin in liver diseases:Molecular mechanisms[J].World Journal of Gastroenterology,2018，24(16):1679-1707.
[68] LIU X,XIE Z H,LIU C Y，et al.Effect of Chinese herbal monomer hairy calycosin on nonalcoholic fatty liver rats and its mechanism[J].Combinatorial Chemistry & High Throughput Screening,2019，22(3):194-200.
[69] 张海威,张力.乔松素临床应用和作用机制的研究进展[J].神经药理学报,2016，6(5):45-52. ZHANG H W,ZHANG L.Research progress on pinocembrin:Potential therapeutic applications and action mechanisms[J].Acta Neuropharmacologica, 2016，6(5):45-52.(in Chinese)
[70] 孙经纬,邵铭.乔松素对高脂饲养诱导的非酒精性脂肪性肝病大鼠的保护作用及机制研究[J].四川中医,2019，37(12):50-54. SUN J W,SHAO M.Protective effect and mechanism of pinocembrin for rats with nonalcoholic fatty liver disease induced by high fat feeding[J].Journal of Sichuan of Traditional Chinese Medicine, 2019，37(12):50-54.(in Chinese)
[71] 舒泳翔,谭诗云,吴鹏波.非酒精性脂肪肝病自噬机制的研究进展[J].医学研究杂志,2016，45(1):4-7. SHU Y X,TAN S Y,WU P B.The research progress on the autophagy mechanism of non-alcoholic fatty liver disease[J].Journal of Medical Research,2016，45(1):4-7.(in Chinese)
[72] FANG X,LAN X,ZHU M,et al.Puerarin induces macrophage M2 polarization to exert antinonalcoholic steatohepatitis pharmacological activity via the activation of autophagy[J].Journal of Agricultural and Food Chemistry,2024，72(13):7187-7202.
[73] 金秋芳,梁国强,葛惠男,等.葛根素联合有氧运动对非酒精性脂肪肝大鼠SIRT1介导肝细胞自噬的保护作用研究[J].河北中医,2020，42(10):1540-1546. JIN Q F,LIANG G Q,GE H N,et al.The study on the protective effect of puerarin combined with aerobic exercise on SIRT1-mediated autophagy in liver cells of non-alcoholic fatty liver disease in rats[J].Hebei Journal of Traditional Chinese Medicine,2020，42(10):1540-1546.(in Chinese)
[74] CHEN S,LU H,YIN G,et al.Hesperitin prevents non-alcoholic steatohepatitis by modulating mitochondrial dynamics and mitophagy via the AMPKα-Drp1/PINK1-Parkin signaling pathway[J].Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids,2025，1870(1):159570.
[75] DU L,DING X,TIAN Y,et al.Effect of anthocyanins on metabolic syndrome through interacting with gut microbiota[J].Pharmacological Research,2024，210:107511.
[76] 周敬凯,翁竞玉,朱盼,等.地菍总黄酮对高脂饮食大鼠减肥作用及肠道菌群的影响[J].中成药,2021，43(10):2673-2678. ZHOU J K,WENG J Y,ZHU P,et al.Effects of total flavonoids from Melastoma dodecandrum on weight loss and intestinal flora in rats fed with high-fat diets[J].Chinese Traditional Patent Medicine,2021，43(10):2673-2678.(in Chinese)
[77] 葛晶晶.基于肠道菌群和肝脏代谢组学研究柑橘类黄酮对非酒精性脂肪肝病的保护作用[D].南昌：南昌大学,2022. GE J J.Study the protective effects of citrus flavonoids on non-alcoholic fatty liver disease based on gut microbiota and liver metabolomics research[D].Nanchang:Nanchang University,2022.(in Chinese)
[78] 王楚婷,孙懿,陈志伟,等.藤茶总黄酮对非酒精性脂肪性肝病模型小鼠肠道菌群的影响[J].医药导报,2024，43(6):867-873. WANG C T,SUN Y,CHEN Z W,et al.The effect of total flavonoids from Tengcha on the gut microbiota of non-alcoholic fatty liver disease model mice[J].Herald of Medicine, 2024，43(6):867-873.(in Chinese)

Research Progress on the Mechanism of Traditional Chinese Medicine Flavonoids in Improving Nonalcoholic Fatty Liver Disease

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