昼夜节律生物钟调控糖脂代谢稳态在奶牛酮病中作用的研究进展

doi:10.16431/j.cnki.1671-7236.2025.07.043

Abstract

Abstract: Ketosis is a nutritional metabolic disease caused by the imbalance of glucose and lipid metabolism in perinatal dairy cows.It is mainly manifested by the accumulation of ketone bodies and the increase of free fatty acids,accompanied by abnormal concentration of blood sugar,insulin and glucagon.The disease seriously endangers the health and production performance of dairy cows and causes huge losses to the dairy farming industry.The core link of ketosis is the disorder of glucose and lipid metabolism.As an important endogenous homeostasis regulation system in mammals,the circadian clock can regulate the circadian rhythm of glucose and lipid metabolism by regulating the secretion of hormones related to glucose and lipid metabolism,the expression of rate-limiting enzyme genes and nuclear receptor genes.This paper reviewed the connection between ketosis and glycolipid metabolism disorders in dairy cows,the role of the circadian clock in the regulation of circadian rhythm homeostasis of lipid and carbohydrate metabolism in mammals,the circadian rhythm of metabolic physiology regulated by circadian clock in dairy cows,and the effects of ketosis on the circadian rhythm of glucose and lipid metabolism in dairy cows,in order to understand the pathogenesis of ketosis in dairy cows more comprehensively from the perspective of chronobiology,and provide new ideas for exploring accurate and efficient prevention and treatment strategy of ketosis.

Key words: ketosis; circadian rhythm; glycolipid metabolism; regulation mechanism

CLC Number:

S857.2⁺1

LIU Jijun, WANG Fengbo, WEI Feng, JIN Yaping, ZHANG Haisen, CHEN Huatao. Research Progress on the Role of Circadian Clock in Regulating Glucose and Lipid Metabolism Homeostasis of Ketosis in Dairy Cows[J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(7): 3449-3458.

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Research Progress on the Role of Circadian Clock in Regulating Glucose and Lipid Metabolism Homeostasis of Ketosis in Dairy Cows

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