中药抗猪繁殖与呼吸综合征病毒的作用机制研究进展

doi:10.16431/j.cnki.1671-7236.2023.05.038

Abstract

Abstract: Porcine reproductive and respiratory syndrome (PRRS) is a highly contagious infectious disease caused by Porcine reproductive and respiratory syndrome virus (PRRSV) that primarily causes reproductive disorders in sows and respiratory symptoms in piglets.Vaccination is the primary methods for preventing and controlling PRRSV,however,because of the high variability of the PRRSV strain,the vaccine’s effect on the disease is still suboptimal.Traditional Chinese medicine (TCM) contains several active components and physiological activities,such as antibacterial,antiviral,and antioxidant actions,which become a hot topic in anti-virus medicine research.Studies have proved that TCM can inhibit the proliferation,block the adsorption and kill the PRRSV in the way of monomer or compound,as well as affect the immune response of the body.TCM anti-PRRSV method comprises both direct and indirect antiviral actions.The direct antiviral mechanism is the direct action of the active components of TCM on the virus’s replication cycle,which is mostly manifested as preventing the virus’s adsorption,internalization,replication,assembly,and release in order to inhibit the virus.The active components of TCM inhibit the negative effects of viruses on host cells by regulating cytokine synthesis,inflammatory signaling pathways,cell apoptosis,oxidative metabolism,and the immune system,ensuring the generation of immune response and reducing body damage.Due to the complex composition of TCM and the unclear anti-PRRSV mechanism,the recent studies on anti-PRRSV of TCM were reviewed based on the antiviral mechanism,in order to provide a theoretical basis for the prevention and control of PRRSV with TCM.

Key words: Porcine reproductive and respiratory syndrome virus (PRRSV); vaccine; traditional Chinese medicine (TCM); antiviral effect; mechanism

CLC Number:

S852.65^＋1

CHEN Tianbao, WANG Yani, LIU Baoling, WANG Gang, WANG Xiaohu, LIU Xuhui, CAI Rujian, HE Dongsheng. Research Progress on the Anti-Porcine Reproductive and Respiratory Syndrome Virus Effect and Mechanism of Traditional Chinese Medicine[J]. China Animal Husbandry & Veterinary Medicine, 2023, 50(5): 2114-2129.

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Research Progress on the Anti-Porcine Reproductive and Respiratory Syndrome Virus Effect and Mechanism of Traditional Chinese Medicine

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