miRNA和lncRNA调控反刍动物卵泡发育的分子机制研究进展

doi:10.16431/j.cnki.1671-7236.2025.02.027

Abstract

Abstract: Follicular development is an important factor in determining ovulation rate and lambing number，it directly affects the reproductive function and fecundity of maternal animals.With the development of omics technology in recent years,microRNA (miRNA) and long non-coding RNA (lncRNA) have played an important regulatory role in the dynamic development of follicle in ruminants.miRNA can participate in the regulation of granulosa cell function,oocyte maturation and follicular development by silencing or inducing the expression of target genes.lncRNA acts as a molecular sponge for miRNA and indirectly regulates gene expression by competitive binding to miRNA,affecting germ cell development and ovarian function within the follicle.The authors review the molecular function and mechanism of miRNA and lncRNA in follicle development of ruminants,and summarize the competitive endogenous RNA (ceRNA) interaction networks among miRNA,lncRNA and gene,in order to provide a reliable genetic resources and theoretical reference for excavating key genes for reproductive traits of maternal animals and carrying out molecular breeding work.

Key words: miRNA; lncRNA; ceRNA interaction mechanism; ruminants; follicular development

CLC Number:

S814

WANG Yong, MA Chi, WANG Chao, ZHAO Qinan, SUN Zhipeng, TIAN Feng, WANG Li, JIN Hai, LI Changqing. Research Progress on Molecular Mechanism of miRNA and lncRNA Regulating Follicular Development in Ruminants[J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(2): 771-780.

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Research Progress on Molecular Mechanism of miRNA and lncRNA Regulating Follicular Development in Ruminants

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