DNA甲基化与去甲基化调控脂肪沉积的研究进展

doi:10.16431/j.cnki.1671-7236.2019.02.023

Abstract

Abstract:

Adipose deposition is a complex biological process,and is regulated by genetic and epigenetic effects.DNA methylation and demethylation are important ways of epigenetic modification,can participate in important life processes such as growth and development of body and cell differentiation by interacting with transcription factors or altering the structure of chromatin.Animal adipose deposition is the result of adipocyte proliferation and differentiation and hypertrophy.Adipocyte differentiation is a process in which pluripotent stem cells are transformed into precursor adipocyte and then differentiated into mature adipocytes.Related studies have shown that the transcription factor peroxisome proliferator activiated receptor γ (PPARγ) and CCAAT enhancer binding protein family (CEBPs) play key regulatory roles in adipose deposition.Recent studies found that DNA methylation can participate in the differentiation of adipocytes and the growth and development of adipose tissue by regulating the expression of related genes in the process of adipogenesis.Demethylation can also affect the adipose deposition process in animals,but the specific mechanism is still unclear.This article introduced the definition,site of occurrence biological function,related enzyme and mechanism of DNA methylation and demethylation,then introduced the adipose deposition process and the role of transcriptional regulators such as PPARγ and C/EBPα in adipose deposition.The effects of DNA methylation and demethylation on the expression of genes involved in adipogenesis and adipocytes differentiation were highlighted.This paper provides a reference for clarifying the mechanism of adipose deposition and improving meat quality in animal production.

Key words: DNA methylation; demethylation; adipose deposition; regulation

CLC Number:

Q341

WANG Hejie, QIN Benyuan, WANG Yuanyuan, GUO Yulong, SONG Pengkang, LIU Yadan, LE Baoyu, ZHANG Ningfang, CHENG Zhimin, GAO Pengfei, GUO Xiaohong, LI Bugao, CAO Guoqing. Research Advances on DNA methylation and Demethylation to Regulate Adipose Deposition[J]. China Animal Husbandry & Veterinary Medicine, 2019, 46(2): 519-525.

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Research Advances on DNA methylation and Demethylation to Regulate Adipose Deposition

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