促性腺激素释放激素及其类似物在母猪繁殖中应用的研究进展

doi:10.16431/j.cnki.1671-7236.2019.02.022

Abstract

Abstract:

Gonadotropin-releasing hormone (GnRH) is a reproductive hormone secreted by the hypothalamus.It mainly participates in regulating the reproductive activities of animals through the hypothalamic-pituitary-gonadal axis,and can also directly play an important role in animal gonads or other organs.GnRH in mammals has the same ten peptide structure.Different GnRH analogues can be synthesized by changing the sixth,ninth and tenth amino acids in the ten peptide structure.GnRH and its analogues can affect animal reproductive performance by stimulating luteinizing hormone (LH) secretion,inhibiting estrogen receptor dimerization and regulating the synthesis of proteins associated with embryo implantation.GnRH and its analogues in production have been shown to increase the fertility of pigs.The application of GnRH analogues still has some problems,such as the significant effect of the second pregnancy,the promotion of ovulation but not the increase of litter size.This paper introduced the application of GnRH and its analogues in sow breeding from such aspects:The source and function of GnRH,the structure of GnRH and its analogues,the structure and function of gonadotropin-releasing hormone receptor,the effect of GnRH and its analogues on reproductive performance of swine,existing problems and prospects.

Key words: gonadotropin-releasing hormone (GnRH); GnRH analogues; porcine reproduction

CLC Number:

S828

LIU Chuang, LI Nan, WEI Qiaoli, FANG Xiaohuan, TIAN Jianhui, WENG Shiqiao, LIU Yan, LI Junjie. Research Progress on Application of Gonadotropin-releasing Hormone and Its Analogues in Porcine Reproduction[J]. China Animal Husbandry & Veterinary Medicine, 2019, 46(2): 512-518.

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Research Progress on Application of Gonadotropin-releasing Hormone and Its Analogues in Porcine Reproduction

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