自噬调控猪脂肪生成的研究进展

doi:10.16431/j.cnki.1671-7236.2024.12.020

Abstract

Abstract: Adipose tissue is an energy storage station in the animal organism and an important endocrine organ.Obesity caused by excessive fat deposition brings about a series of metabolic diseases,such as fatty liver,cardiovascular disease and insulin resistance.Similarly,porcine adipogenesis influences traits such as disease resistance,reproductive performance,meat quality and productivity,which affect the economic efficiency of hog production.Mature adipocytes are obtained by differentiation of mesenchymal stem cells,a process in which many signaling pathways and transcription factors are involved via preadipocytes.Autophagy is usually the most important means of catabolizing redundant components of the organism and is involved in the maintenance of homeostasis.There is a close link between autophagy and adipogenesis,active adipogenesis is accompanied by elevated levels of autophagy,and impaired autophagy is accompanied by suppressed adipogenesis.There are many related transcription factors and signaling pathways that regulate porcine adipogenesis during autophagic activities,and many transcription factors are involved in the process of porcine adipogenesis.By summarizing the newly reported transcription factors and signaling pathways related to autophagy regulation of adipogenesis,the author elaborates the research progress on autophagy involved in the regulation of porcine adipogenesis,which provides a new idea and target point for the regulation of porcine nutrition and meat quality breeding.

Key words: pigs; autophagy; adipogenesis; transcription factor; regulation

CLC Number:

S852.23

HONG Chun, ZHU Xiangxing, LI Xinming, HUANG Qiuyan, LIU Wenhua, DU Zongliang, TANG Dongsheng, WANG Sutian. Progress on Autophagy Regulation of Porcine Adipogenesis[J]. China Animal Husbandry & Veterinary Medicine, 2024, 51(12): 5325-5334.

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Progress on Autophagy Regulation of Porcine Adipogenesis

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