中国畜牧兽医 ›› 2026, Vol. 53 ›› Issue (2): 622-630.doi: 10.16431/j.cnki.1671-7236.2026.02.010
胡琦1,2(
), 唐兴刚2, 袁明贵2, 八晓敏2, 田雅2, 张晓爱3, 叶倩妮2(
), 向蓉2(
)
收稿日期:2025-06-30
出版日期:2026-02-20
发布日期:2026-01-28
通讯作者:
叶倩妮,向蓉
E-mail:1969145088@qq.com;yeqianni@gdaas.cn;23753842@qq.com
作者简介:胡琦,E-mail:1969145088@qq.com
基金资助:
HU Qi1,2(
), TANG Xinggang2, YUAN Minggui2, BA Xiaomin2, TIAN Ya2, ZHANG Xiaoai3, YE Qianni2(
), XIANG Rong2(
)
Received:2025-06-30
Online:2026-02-20
Published:2026-01-28
Contact:
YE Qianni, XIANG Rong
E-mail:1969145088@qq.com;yeqianni@gdaas.cn;23753842@qq.com
摘要:
美洛昔康是一种高选择性环氧合酶-2抑制剂,属于临床常用非甾体抗炎药。其通过有效抑制前列腺素合成,进而发挥显著的抗炎镇痛作用;同时,美洛昔康对环氧合酶-1抑制活性较弱,能显著降低胃肠道及肾脏不良反应风险,使其成为犬猫临床治疗中安全、高效的关键抗炎镇痛药。近年来,随着宠物医疗需求的不断增长,美洛昔康的临床应用价值持续提升。笔者概述了美洛昔康的理化性质与作用机制,系统比较了目前临床常用剂型的优缺点,并进一步探讨了口服半固体制剂及微针贴片等新剂型在提升给药便利性和动物依从性上的潜力。重点评析了美洛昔康在犬猫关节疾病、肿瘤辅助治疗、胰腺炎肠道保护及围手术期镇痛等领域应用的研究进展,分析了当前临床应用所面临的挑战及未来研究方向。以期为美洛昔康在宠物犬猫临床治疗中的安全、合理及高效用药提供科学参考,同时为其创新研发与转化研究提供新思路。
中图分类号:
胡琦, 唐兴刚, 袁明贵, 八晓敏, 田雅, 张晓爱, 叶倩妮, 向蓉. 美洛昔康在犬猫临床应用中的研究进展[J]. 中国畜牧兽医, 2026, 53(2): 622-630.
HU Qi, TANG Xinggang, YUAN Minggui, BA Xiaomin, TIAN Ya, ZHANG Xiaoai, YE Qianni, XIANG Rong. Research Progress on the Clinical Application of Meloxicam in Dogs and Cats[J]. China Animal Husbandry & Veterinary Medicine, 2026, 53(2): 622-630.
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