反10，顺12共轭亚油酸的生物学功能及其在畜禽中的应用

doi:10.16431/j.cnki.1671-7236.2026.02.009

Abstract

Abstract:

Trans-10，cis-12conjugated linoleic acid （t10，c12-CLA） is a type of isomer of conjugated linoleic acid （CLA）， and it possesses various biological functions， such as anti-obesity， anti-inflammation， and anti-diabetes. The biological functions and signaling pathways of t10， c12-CLA have shown extensive application prospects and significant value in multiple different fields. However， the mechanism of action of t10， c12-CLA has not yet been fully elucidated. The author has comprehensively reviewed the research results of t10， c12-CLA in livestock and poultry， with a particular focus on the effects on key aspects such as oocyte development， function of mammary epithelial cells， muscle growth， regulation of milk fat content， regulation of fat metabolism， immune function， and lipid regulation. Furthermore， the molecular mechanism of t10， c12-CLA was explored， aiming to provide a reference basis for in-depth research on related issues in the livestock industry and to promote the development of the livestock sector.

Key words: trans-10，cis-12 conjugated linoleic acid; biological functions; livestock and poultry; molecular mechanism

CLC Number:

S814

WANG Na, LIU Yuanyi, YANG Mingying, SHI Yujie, LI Xinyu, CAO Jialong, HE Qianqian, DU Ming, MANG Lai. Biological Functions of Trans-10，Cis-12 Conjugated Linoleic Acid and Its Application in Livestock and Poultry[J]. China Animal Husbandry & Veterinary Medicine, 2026, 53(2): 610-621.

Figures/Tables 5

Fig.1

Fig.2

Table 1

Table 2

Table 3

References 58

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介导途径 Mediating pathway	作用 Effect	参考文献References
酰基肽水解酶 Acylpeptide hydrolase 蛋白酶体 Proteasome	降低癌细胞活力	Bergamo等^［19］
脂肪酸合酶的下调作用 Down-regulation effect of fatty acid synthase	抑制癌细胞生长（高剂量t10，c12-CLA）	Lau等^［20］
胰岛素样生长因子-1受体信号的抑制及Akt和细胞外信号调节激酶-1/2的激活 Inhibition of insulin-like growth factor-1 receptor signaling and activation of Akt and extracellular signal-regulated kinase-1/2	抑制TSU-Pr1人膀胱癌细胞增殖，促进细胞凋亡	Jung等^［21］
抑制胰岛素样生长因子-2分泌 Inhibit the secretion of insulin-like growth factor-2	抑制肿瘤细胞增殖	董贵成等^［22］
激活AMPK-p38 MAPK-Bim信号通路 Activation of AMPK-p38 MAPK-Bim signaling pathway	诱导TM4t乳腺肿瘤细胞凋亡	Hsu等^［23］

生物学功能 Biological function	调节因子 Regulatory factors	作用 Effect	参考文献 References
抗脂肪生成 Inhibit adipogenesis	棕色脂肪组织、皮下腹股沟白色脂肪组织	促进产热、提高能量消耗，间接减少白色脂肪沉积	梁露文^［30］
抗脂肪生成 Inhibit adipogenesis	Δ9-去饱和酶指数、脂肪细胞分化标志物	脂肪生成减少和分化程度降低	Martins等^［31］
抗动脉粥样硬化 Anti-atherosclerosis	动脉血管中细胞的凋亡水平	抑制动脉粥样硬化斑块的产生	陆家琦^［32］
抗动脉粥样硬化 Anti-atherosclerosis	甘油三酯、总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇	减少动脉粥样硬化斑块的形成	刘佩等^［33］
脂质代谢 Lipid metabolism	5′-单磷酸腺苷活化蛋白激酶（AMPK）、前列腺素	脂肪细胞中脂质含量降低	Jiang等^［34］
	结肠癌细胞（Caco-2细胞）内源性甘油三酯	调节肠道脂蛋白代谢	Black等^［35］
	PLC-AMPK通路	降低前脂肪细胞中甘油三酯含量，促进脂肪氧化分解，抑制脂肪分化	徐文涛^［36］

Biological Functions of Trans-10，Cis-12 Conjugated Linoleic Acid and Its Application in Livestock and Poultry

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