自噬在细菌感染中的作用机制研究进展

doi:10.16431/j.cnki.1671-7236.2025.09.045

Abstract

Abstract: Bacterial infection refers to an acute systemic infection caused by pathogenic bacteria or conditional pathogenic bacteria that invade the blood circulation to grow and multiply and produce toxins and other metabolites.It evades autophagy by destroying or utilizing autophagic virulence proteins or related molecules,affecting various organs and tissues,and causing serious impacts on the health and production performance of livestock and poultry.Due to the characteristics of diverse serotypes,high drug resistance and long survival time in nature,which makes the prevention and control of bacteria particularly complex. At the same time,bacterial infection involves multiple pathways,and most of the research mainly focuses on bacterial metabolism,nucleic acid synthesis,toxins and virulence factors,immune regulation,inflammation and immunopathological mechanisms,etc.Meanwhile,autophagy is closely related to the mechanism.Therefore,the research on bacterial infection and autophagy had gradually become one of the hot spots in the intersection of microbiology,immunology and cell biology at present.Autophagy plays an important role in the host’s defense against bacterial infections,but bacteria may also evade the host’s immune clearance by interfering with the autophagy pathway.Therefore,an in-depth analysis of the molecular mechanism of the interaction between bacteria and autophagy and the exploration of new autophagy regulatory targets are of specific significance for the development of novel antibacterial drugs and treatment regimens.The author summarized the role of autophagy in bacterial infections and discussed how host cells evade bacterial infections in the body through the autophagy mechanism,so as to provide new ideas for targeted autophagy treatment of bacterial infection.

Key words: bacterial infection; autophagy; autophagosome; signal pathway

CLC Number:

S852.21

LEI Xingfen, LI Shun, HUANG Yunfei, LI Yajuan, SUN Qinqin, FU Qiang. Research Progress on the Mechanism of Autophagy in Bacterial Infection[J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(9): 4505-4514.

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Research Progress on the Mechanism of Autophagy in Bacterial Infection

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