肠道菌群-miRNA互作机制及其对疾病防治的影响

doi:10.16431/j.cnki.1671-7236.2025.09.028

Abstract

Abstract: Intestinal flora regulates the biological process of organisms and affects the health and diseases of hosts.microRNAs (miRNAs),as important regulators,are related to health and disease.It is found that there is a bidirectional regulatory relationship between intestinal flora and miRNA.Therefore,more and more researches focus on revealing the influence of intestinal flora-miRNA interaction on many biological processes such as health and diseases.In this paper,firstly,the main mechanism of the interaction between intestinal flora and miRNA is combed and summarized.miRNA can enter bacteria and specifically affect the growth of intestinal microorganisms,as well as their proliferation activity,steady state,colonization,structure,composition,abundance,adaptability and gene expression.Conversely,intestinal flora can also regulate miRNA,mainly by affecting the expression of host miRNA,metabolites,secondary microbial metabolites,probiotics and lipopolysaccharide.Then,based on the theory that "the lung and the large intestine are exterior to interior" and the intestinal flora connects the lung and the large intestine,it is discussed that the interaction of intestinal flora-miRNA has the potential to mediate the operation of the "lung-intestine axis".Then,by summarizing the effects of intestinal flora and miRNA on inflammation,it is concluded that the intestinal flora-miRNA axis can mediate many diseases and inflammatory pathways.Finally,combined with the interaction between traditional Chinese medicine and intestinal flora,the regulation of traditional Chinese medicine on miRNA and the effect of intestinal flora on exogenous miRNA,it is found that the intestinal flora-miRNA axis has great potential to mediate the prevention and treatment of diseases by traditional Chinese medicine.To sum up,the in-depth study of the interaction mechanism of intestinal flora-miRNA axis provides a reliable basis for the discussion of the pathogenesis,prevention and treatment mechanism of diseases and the mining of their targets.

Key words: intestinal flora; miRNA; lung-intestine axis; inflammatory pathway; traditional Chinese medicine

CLC Number:

S852.6

LU Xiaorong, ZHAO Yiduo, LI Jianxi. Interaction Mechanism of Intestinal Flora-miRNA and Its Influence on Disease Prevention and Treatment[J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(9): 4304-4318.

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Interaction Mechanism of Intestinal Flora-miRNA and Its Influence on Disease Prevention and Treatment

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