黑果枸杞提取物对八眉三元猪脂质代谢的影响

doi:10.16431/j.cnki.1671-7236.2026.01.022

Abstract

Abstract:

Objective This study aimed to investigate the effects of dietary supplementation with Lycium ruthenicum Murr. extract of different concentrations on lipid profiles， adipose tissue morphology， and the expression of lipid metabolism-related genes and proteins in Bamei ternary hybrid pigs. Method Forty-eight Bamei ternary hybrid pigs aged （50±2） days with an average weight of 7.83 kg±0.52 kg were randomly divided into four groups， with three replicates per group and four pigs per replicate. The pigs were fed either a basal diet （CON group） or diets supplemented with 5， 10， and 15 g/kg of Lycium ruthenicum Murr. extract （LE， ME， and HE groups）， respectively. The experimental period was 42 days. At the end of the experiment， two pigs from each replicate were slaughtered， and blood， abdominal subcutaneous fat， and epididymal fat tissue were collected for the measurement of serum lipid levels， observation of fat tissue cell morphology， and mRNA and protein expression of lipid metabolism-related factors in fat tissues. Result Compared with CON group， ①Serum triglyceride （TG） levels of pigs in LE， ME， and HE groups were significantly reduced （P<0.05）， serum total cholesterol （TCH） levels were significantly reduced （P<0.05）， and serum high-density lipoprotein cholesterol （HDL-C） levels in LE group were significantly increased （P<0.05）. ②The area of lipid droplets in the subcutaneous adipose tissue of the abdomen of pigs in ME group was significantly reduced （P<0.05）， while there was no significant difference in the area of lipid droplets in the epididymal adipose tissue （P>0.05）. ③ In LE， ME， and HE groups， the mRNA and protein expression of lipid synthesis-related factors （PPARγ， ACC， and SREBP1） in abdominal subcutaneous fat and epididymal fat were significantly or extremly significantly reduced （P<0.05 or P<0.01）， while the mRNA and protein expression of lipid degradation-related factors （CPT1 and HSL） were significantly or extremly significantly up-regulated （P<0.05 or P<0.01）. Conclusion Adding Lycium ruthenicum Murr. extract to the diet could significantly reduce lipid deposition in the abdominal subcutaneous fat of Bamei ternary hybrid pigs by inhibiting the expression of lipid synthesis-related factors （PPARγ，ACC，and SREBP1） and promoting the expression of lipid degradation-related factors （CPT1 and HSL）， with the 10 g/kg addition showing the best effect.

Key words: Lycium ruthenicum Murr. extract; Bamei ternary hybrid pigs; blood lipid indicators; cell morphology; lipid metabolism

CLC Number:

S816.7

CHEN Lin, LIU Jiayi, WU Hua, ZHANG Yuan, DENG Zhijie, HAN Yaohui, SHI Yinliang. Effects of Lycium ruthenicum Murr. Extract on Lipid Metabolism in Bamei Ternary Hybrid Pigs[J]. China Animal Husbandry & Veterinary Medicine, 2026, 53(1): 245-255.

Figures/Tables 6

Table 1

Table 2

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原料Ingredients	含量Contents	营养成分Nutrient components^②	含量Contents
玉米Corn	57.22	消化能DE/（MJ/kg）	13.45
小麦Wheat	15.00	粗蛋白质CP	16.52
干酒糟及其可溶物DDGS	5.00	钙Ca	0.72
豆粕Soybean meal	16.50	磷P	0.65
石粉Limestone	0.90	赖氨酸Lys	0.93
食盐NaCl	0.35	蛋氨酸Met	0.50
碳酸氢钙Ca（HCO₃）₂	0.60
L-赖氨酸硫酸盐L-Lys · H₂SO₄	0.25
DL-蛋氨酸DL-Met	0.18
预混料Premix^①	4.00
合计 Total	100.00

基因 Genes	登录号 Accession No.	引物序列 Primer sequences （5'→3'）	产物长度 Product length/bp
PPARγ	NM_214379.1	F：CTCTGTGGACCTGTCGGTGATG R：GTGGAGTGGAAATGCAGAAATC	134
ACC	NM_001114269.1	F：ATTGACACTGGCTGGCTGGAC R：AGATGCTGTTCCGAAGGCTCAC	244
HSL	NM_214315.3	F：CCTCGGCTGTCAACTTCTTATTTCG R：CCTCCTTGGTGCTAATCTCGTCTC	397
SREBP1	NM_214157.1	F：GTGCTGGCGGAGGTCTATGTG R：AGGAAGAAGCGGGTCAGAAAGTG	153
CPT1	NM_001129805.1	F：CCTACCAGATGGAGCGGATGTTC R：TCGTAGAGCCACACCTTGAAGAAG	168
β-actin	NC_010445.4	F：CCAGGTCATCACCATCGG R：CCGTGTTGGCGTAGAGGT	139

项目Items	组别Groups
项目Items	CON	LE	ME	HE
甘油三酯TG	0.68±0.01^a	0.39±0.06^b	0.43±0.03^b	0.42±0.05^b
总胆固醇TCH	3.64±0.34^a	2.43±0.41^b	2.92±0.48^ab	2.89±0.63^ab
高密度脂蛋白胆固醇HDL-C	1.06±0.10^b	1.83±0.11^a	1.28±0.29^b	1.30±0.35^b
低密度脂蛋白胆固醇LDL-C	1.93±0.38	1.49±0.37	1.86±0.10	1.79±0.33

Effects of Lycium ruthenicum Murr. Extract on Lipid Metabolism in Bamei Ternary Hybrid Pigs

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