脂源性外泌体miRNA对脂代谢调控作用的研究进展

doi:10.16431/j.cnki.1671-7236.2023.10.008

Abstract

Abstract: As a new mode of intercellular information exchange,exosomes regulate a variety of biological processes under physiology and pathology recipient cell functions through the factors they carry,such as miRNA,mRNA and proteins.miRNAs are one of the main factors in the functioning of exosomes,without protein coding,miRNAs are 19-25 nt in length and single-stranded RNAs.miRNAs cause inhibition of mRNA translation or degradation of transcripts by binding to target genes,which has regulatory effects on lipid metabolism.Exosomes have a lipid bilayer membrane structure that serves as a good carrier for miRNA transport to recipient cells,where they play a role in physiological and pathological processes.The regulatory role of exosomal miRNAs may be a new type of inter-tissue communication.Adipose tissue is the main endocrine organ of livestock and poultry,and the adipokines it secretes play an important role in regulating the metabolic homeostasis of the body.As a novel adipokine,adipose-derived exosomal miRNAs regulate gene expression in other tissues and play an important role in maintaining metabolic homeostasis in vivo.The author reviews the molecular regulatory role and related mechanisms of lipid derived exosomes miRNAs in lipid metabolism,aiming to provide theoretical support for studying the mechanism of lipid derived exosomes miRNAs,preventing and treating metabolic related diseases.

Key words: exosomes; miRNA; lipid metabolism; adipose cell

CLC Number:

S852.21

HE Yue, CHEN Mengdi, BAI Jinhui, SONG Jixuan, XIA Guangjun. Research Progress on the Regulation of miRNA from Adipose-derived Exosomes on Lipid Metabolism[J]. China Animal Husbandry & Veterinary Medicine, 2023, 50(10): 3950-3958.

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Research Progress on the Regulation of miRNA from Adipose-derived Exosomes on Lipid Metabolism

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