光学和电化学生物传感器对奶牛重要疾病诊断的研究进展

doi:10.16431/j.cnki.1671-7236.2023.02.040

Abstract

Abstract: With the large-scale and intensive development of dairy farming in China,and the excessive pursuit of dairy production performance,it is easy for dairy cows to occur diseases.Subclinical ketosis,subclinical hypocalcemia,mastitis,foot-and-mouth disease,respiratory diseases and bovine viral diarrhea are mainly nutritional and infectious diseases,which threaten the health and welfare of dairy cows and bring about the decrease of milk quality and the increase of financial loss of farm.The timely and rapid detection of diseases is a key step to control the infection among livestock,reduce the damage of economy,and protect the food safety.Although cell culture methods,enzyme-linked immunoabsorbent assay (ELISA),polymerase chain reaction (PCR) and some other methods have been applied in the detection of diseases of livestock and poultry,it’s still difficult to carry on the detecting work due to the limitations of time consuming and high-cost and complicated procedures of present methods,and unsuitable for point-of-care testing of diseases of dairy cow.Biosensor depends on a transductor to convert the sign originating from specific biochemical interaction between the biomarker and the bioreceptor into a measurable signal,and on a signal amplification system to detect the biomarker qualitatively or quantitatively.There is great potential for biosensor in detecting metal ion,pathogenic bacteria with advantages of simple operation,high sensitivity and strong specificity.Currently,there are various kinds of biosensors designed for the detection of diseases of diary cow.In this review,we provided an overview of the corresponding electrochemical and optical biosensors for common diseases of dairy cows.The descriptions illustrated the detection strategy,detection range and limit and other information of each biosensor.In the last section,this paper prospected the development tendency of biosensor,in order to provide references for the healthy development of dairy cow.

Key words: biosensor; photoelectric sensing; dairy cows; disease diagnosis

CLC Number:

S858.23

HE Yue, WANG Hui, CHEN Ruipeng, YU Zhixue, TANG Xiangfang, GUO Yuming, XIONG Benhai. Research Progress on Optical and Electrochemical Biosensors for the Diagnosis of Important Diseases in Dairy Cows[J]. China Animal Husbandry & Veterinary Medicine, 2023, 50(2): 827-837.

References

[1] NEETHIRAJAN S.Recent advances in wearable sensors for animal health management[J]. Sensing and Bio-Sensing Research,2017,12:15-29.
[2] NEETHIRAJAN S,TUTEJA S K,HUANG S T,et al.Recent advancement in biosensors technology for animal and livestock health management[J]. Biosensors and Bioelectronics,2017,98:398-407.
[3] VIDIC J,MANZANO M,CHANG C M,et al.Advanced biosensors for detection of pathogens related to livestock and poultry[J]. Veterinary Research,2017,48(1):11-32.
[4] GATTANI A,SINGH S V,AGRAWAL A,et al.Recent progress in electrochemical biosensors as point of care diagnostics in livestock health[J]. Analytical Biochemistry,2019,579:25-34.
[5] IDIL N,HEDSTRÖM M,DENIZLI A,et al.Whole cell based microcontact imprinted capacitive biosensor for the detection of Escherichia coli[J]. Biosensors and Bioelectronics,2017,87:807-815.
[6] WANG D,CHEN Q,HUO H,et al.Efficient separation and quantitative detection of Listeria monocytogenes based on screen-printed interdigitated electrode,urease and magnetic nanoparticles[J]. Food Control,2017,73:555-561.
[7] BHALLA N,JOLLY P,FORMISANO N,et al.Introduction to biosensors[J]. Essays in Biochemistry,2016,60(1):1-8.
[8] BANDODKAR A J,WANG J.Non-invasive wearable electrochemical sensors:A review[J]. Trends in Biotechnology,2014,32(7):363-371.
[9] DU Y,DONG S.Nucleic acid biosensors:Recent advances and perspectives[J]. Analytical Chemistry,2017,89(1):189-215.
[10] PIPCHUK A,YANG X.Using biosensors to study protein-protein interaction in the hippo pathway[J]. Frontiers in Cell and Developmental Biology,2021,9:660137.
[11] AHMED A,RUSHWORTH J V,HIRST N A,et al.Biosensors for whole-cell bacterial detection[J]. Clinical Microbiology Reviews,2014,27(3):631-646.
[12] DROBYSH M,RAMANAVICIENE A,VITER R,et al.Biosensors for the determination of SARS-CoV-2 virus and diagnosis of COVID-19 infection[J]. International Journal of Molecular Sciences,2022,23(2):666-690.
[13] IGUCHI S,KUDO H,SAITO T,et al.A flexible and wearable biosensor for tear glucose measurement[J]. Biomedical Microdevices,2007,9(4):603-609.
[14] GUINOVART T,BANDODKAR A J,WINDMILLER J R,et al.A potentiometric tattoo sensor for monitoring ammonium in sweat[J]. Analyst,2013,138(22):7031-7038.
[15] KHODAGHOLY D,CURTO V F,FRASER K J,et al.Organic electrochemical transistor incorporating an ionogel as a solid state electrolyte for lactate sensing[J]. Journal of Materials Chemistry,2012,22(10):4440-4443.
[16] FU X,SUN J,LIANG R,et al.Application progress of microfluidics-integrated biosensing platforms in the detection of foodborne pathogens[J]. Trends in Food Science & Technology,2021,116:115-129.
[17] SRINIVASAN B,TUNG S.Development and applications of portable biosensors[J]. Journal of Laboratory Automation,2015,20(4):365-389.
[18] NGUYEN H H,LEE S H,LEE U J,et al.Immobilized enzymes in biosensor applications[J]. Materials (Basel),2019,12(1):121-154.
[19] AHMED M U,ZOUROB M,TAMIYA E,et al.Immunosensors[M].London:The Royal Society of Chemistry,2019.
[20] MINUNNI M.Biosensors based on nucleic acid interaction[J]. Spectroscopy,2003,17:613-625.
[21] CHANG D,ZAKARIA S,ESMAEILI SAMANI S,et al.Functional nucleic acids for pathogenic bacteria detection[J]. Accounts of Chemical Research,2021,54(18):3540-3549.
[22] GUI Q,LAWSON T,SHAN S,et al.The application of whole cell-based biosensors for use in environmental analysis and in medical diagnostics[J]. Sensors (Basel),2017,17(7):1623-1639.
[23] LI H,LIU X,LI L,et al.CMOS electrochemical instrumentation for biosensor microsystems:A review[J]. Sensors,2017,17(1):74-99.
[24] MALHOTRA B D,ALI M A.Nanomaterials for Biosensors[M].Oxford:William Andrew Publishing,2018.
[25] YOO S M,LEE S Y.Optical biosensors for the detection of pathogenic microorganisms[J]. Trends in Biotechnology,2016,34(1):7-25.
[26] POHANKA M.The piezoelectric biosensors:Principles and applications,a review[J]. International Journal of Electrochemical Science,2017,12(1):496-506.
[27] SADASIVUNI K K,PONNAMMA D,KIM J,et al.Biopolymer Composites in Electronics[M].Amsterdam:Elsevier,2017.
[28] DUFFIELD T.Subclinical ketosis in lactating dairy cattle[J]. Veterinary Clinics of North America:Food Animal Practice,2000,16(2):231-253.
[29] JEONG J K,CHOI I S,MOON S H,et al.Effect of two treatment protocols for ketosis on the resolution,postpartum health,milk yield,and reproductive outcomes of dairy cows[J]. Theriogenology,2018,106:53-59.
[30] KAUFMAN E I,LEBLANC S J,MCBRIDE B W,et al.Association of rumination time with subclinical ketosis in transition dairy cows[J]. Journal of Dairy Science,2016,99(7):5604-5618.
[31] GARRO C J,MIAN L,COBOS ROLDÁN M.Subclinical ketosis in dairy cows:Prevalence and risk factors in grazing production system[J]. Journal of Animal Physiology and Animal Nutrition,2014,98(5):838-844.
[32] WENG X,CHEN L,NEETHIRAJAN S,et al.Development of quantum dots-based biosensor towards on-farm detection of subclinical ketosis[J]. Biosensors and Bioelectronics,2015,72:140-147.
[33] WENG X,ZHAO W,NEETHIRAJAN S,et al.Microfluidic biosensor for β-hydroxybutyrate (βHBA) determination of subclinical ketosis diagnosis[J]. Journal of Nanobiotechnology,2015,13:13-20.
[34] ZHANG X,JU H,WANG J.Electrochemical Sensors,Biosensors and Their Biomedical Applications[M].San Diego:Academic Press,2008.
[35] TUTEJA S K,DUFFIELD T,NEETHIRAJAN S.Liquid exfoliation of 2D MoS₂ nanosheets and their utilization as a label-free electrochemical immunoassay for subclinical ketosis[J]. Nanoscale,2017,9(30):10886-10896.
[36] LUKA G,AHMAD S,FALCONE N,et al.Bioelectronics and Medical Devices[M].Duxford,United Kingdom:Woodhead Publishing 2019.
[37] THIRUVENGADAM M,VENKIDASAMY B,SELVARAJ D,et al.Sensitive screen-printed electrodes with the colorimetric zone for simultaneous determination of mastitis and ketosis in bovine milk samples[J]. Journal of Photochemistry and Photobiology B:Biology,2020,203:111746-111751.
[38] SEIFI H A,KIA S.Subclinical hypocalcemia in dairy cows:Pathophysiology,consequences and monitoring[J]. The Iranian Journal of Veterinary Science and Technology,2017,9(2):1-15.
[39] MCART J A A,NEVES R C.Association of transient,persistent,or delayed subclinical hypocalcemia with early lactation disease,removal,and milk yield in Holstein cows[J]. Journal of Dairy Science,2020,103(1):690-701.
[40] WILKENS M R,NELSON C D,HERNANDEZ L L,et al.Symposium review:Transition cow calcium homeostasis—health effects of hypocalcemia and strategies for prevention[J]. Journal of Dairy Science,2020,103(3):2909-2927.
[41] COUTO SERRENHO R,DEVRIES T J,DUFFIELD T F,et al.Graduate student literature review:What do we know about the effects of clinical and subclinical hypocalcemia on health and performance of dairy cows?[J]. Journal of Dairy Science,2021,104(5):6304-6326.
[42] LENO B M,MARTENS E M,FELIPPE M J B,et al.Short communication:Relationship between methods for measurement of serum electrolytes and the relationship between ionized and total calcium and neutrophil oxidative burst activity in early postpartum dairy cows[J]. Journal of Dairy Science,2017,100(11):9285-9293.
[43] SUZUKI K,KONDO N,TAKAGI K,et al.Validation of the bovine blood calcium checker as a rapid and simple measuring tool for the ionized calcium concentration in cattle[J]. The Journal of Veterinary Medical Science,2021,83(5):767-774.
[44] YILMAZ O,KARAPINAR T.Evaluation of the i-STAT analyzer for determination of ionized calcium concentrations in bovine blood[J]. Veterinary Clinical Pathology,2019,48(1):31-35.
[45] BAI Y,SHU T,SU L,et al.Functional nucleic acid-based fluorescence polarization/anisotropy biosensors for detection of biomarkers[J]. Analytical and Bioanalytical Chemistry,2020,412(25):6655-6665.
[46] WANG H,ZHANG F,WANG Y,et al.DNAzyme-amplified electrochemical biosensor coupled with pH meter for Ca²⁺ determination at variable pH environments[J]. Nanomaterials,2022,12(1):4-22.
[47] WANG H,LUO Q,ZHAO Y,et al.Electrochemical device based on nonspecific DNAzyme for the high-accuracy determination of Ca²⁺ with Pb²⁺ interference[J]. Bioelectrochemistry,2021,140:107732-107740.
[48] YU Z,WANG H,ZHAO Y,et al.Electrochemical biosensor using nitrogen-doped graphene/Au nanoparticles/DNAzyme for Ca²⁺ determination[J]. Biosensors (Basel),2022,12(5):331-346.
[49] ASHRAF A,IMRAN M.Diagnosis of bovine mastitis:From laboratory to farm[J]. Tropical Animal Health and Production,2018,50(6):1193-1202.
[50] ZHANG J,JIANG Y,XIA X,et al.An on-site,highly specific immunosensor for Escherichia coli detection in field milk samples from mastitis-affected dairy cattle[J]. Biosensors and Bioelectronics,2020,165:112366-112373.
[51] SOARES A C,SOARES J C,RODRIGUES V C,et al.Controlled molecular architectures in microfluidic immunosensors for detecting Staphylococcus aureus[J]. Analyst,2020,145(18):6014-6023.
[52] SÁNCHEZ-VISEDO A,GALLEGO B,ROYO L J,et al.Visual detection of microRNA146a by using RNA-functionalized gold nanoparticles[J]. Microchimica Acta,2020,187(3):192-200.
[53] WELBECK K,LEONARD P,GILMARTIN N,et al.Generation of an anti-NAGase single chain antibody and its application in a biosensor-based assay for the detection of NAGase in milk[J]. Journal of Immunological Methods,2011,364(1):14-20.
[54] CHINNAPPAN R,AL ATTAS S,KAMAN W E,et al.Development of magnetic nanoparticle based calorimetric assay for the detection of bovine mastitis in cow milk[J]. Analytical Biochemistry,2017,523:58-64.
[55] GRUBMAN M J,BAXT B.Foot-and-mouth disease[J]. Clinical Microbiology Reviews,2004,17(2):465-493.
[56] NIEDBALSKI W.Recent progress in the diagnosis of foot-and-mouth disease:Rapid field-based assays[J]. Medycyna Weterynaryjna,2016,72(6):339-344.
[57] HAMDY M E,DEL CARLO M,HUSSEIN H A,et al.Development of gold nanoparticles biosensor for ultrasensitive diagnosis of Foot and mouth disease virus[J]. Journal of Nanobiotechnology,2018,16(1):48-59.
[58] HUSSEIN H A,HASSAN R Y A,EL NASHAR R M,et al.Designing and fabrication of new VIP biosensor for the rapid and selective detection of Foot-and-mouth disease virus (FMDV)[J]. Biosensors and Bioelectronics,2019,141:111467-111474.
[59] HUSSEIN H A,EL NASHAR R M,EL-SHERBINY I M,et al.High selectivity detection of FMDV-SAT-2 using a newly-developed electrochemical nanosensors[J]. Biosensors and Bioelectronics,2021,191:113435-113443.
[60] GUO T,ZHANG J,CHEN X,et al.Investigation of viral pathogens in cattle with bovine respiratory disease complex in Inner Mongolia,China[J]. Microbial Pathogenesis,2021,153:104594-104599.
[61] DE OLIVEIRA L G,MECHLER-DREIBI M L,ALMEIDA H M S,et al.Bovine viral diarrhea virus:Recent findings about its occurrence in pigs[J]. Viruses,2020,12(6):600-611.
[62] QUINTERO RODRÍGUEZ L E,DOMÍNGUEZ G,ALVARADO PINEDO M F,et al.Association of Bovine viral diarrhea virus,Bovine herpesvirus 1,and Neospora caninum with late embryonic losses in highly supplemented grazing dairy cows[J]. Theriogenology,2022,194:126-132.
[63] LUO Y,NARTKER S,MILLER H,et al.Surface functionalization of electrospun nanofibers for detecting E.coli O157∶H7 and BVDV cells in a direct-charge transfer biosensor[J]. Biosensors and Bioelectronics,2010,26(4):1612-1617.
[64] MONTROSE A,CREEDON N,SAYERS R,et al.Novel single gold nanowire-based electrochemical immunosensor for rapid detection of bovine viral diarrhoea antibodies in serum[J]. Journal of Biosensors & Bioelectronics,2015,6(3):1000174-1000181.
[65] HEIDARI Z,REZATOFIGHI S E,RASTEGARZADEH S.Development and comparison of cross-linking and non-crosslinking probe-gold nanoparticle hybridization assays for direct detection of unamplified Bovine viral diarrhea virus-RNA[J]. BMC Biotechnology,2021,21(1):30-42.
[66] TARASOV A,GRAY D W,TSAI M Y,et al.A potentiometric biosensor for rapid on-site disease diagnostics[J]. Biosensors and Bioelectronics,2016,79(10):669-678.
[67] GARCIA L F,SILVIO BATISTA RODRIGUES E S, LINO DE SOUZA G R,et al.Impedimetric biosensor for Bovine herpesvirus type 1-antigen detection[J]. Electroanalysis,2020,32(5):1100-1106.
[68] BOBY N,ALI S A,PREENA P,et al.Detection of multiple organisms based on the distance-dependent optical properties of gold nanoparticle and dark-field microscopy[J]. Talanta,2018,188(80):325-331.

Research Progress on Optical and Electrochemical Biosensors for the Diagnosis of Important Diseases in Dairy Cows

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	ZHAO Jinghong, MA Hui, LIU Jintao, MIAO Renfang, LIU Hongzhi, LIU Duncheng, QU Yongli. Effects of Supplemental Light on Blood Endocrine Hormone Concentrations and Circadian Rhythm Changes in Late-gestation Holstein Breeding Dairy Cows [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(7): 3178-3189.
[2]	LIU Zhixu, HAN Wenchang, LI Yanqin, ZHANG Liwen, LIU Yan, YUAN Shaowei, LIJianbin, WANG Xiao, CAO Rongfeng. Study on the Correlation Between β-lactase blaZ Gene and Microorganisms in Milk of Cows with Latent Mastitis in Shandong Region [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(5): 2318-2327.
[3]	HAN Yurun, SHI Yuangang, KANG Xiaolong. Influencing Factors of Ruminating Behavior and the Application of Intelligent Monitoring Methods in Dairy Cows [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(4): 1554-1566.
[4]	LIU Tuo, CHENG Zhiqiang, CHENG Zhe, ZANG Changjiang, NAN Bingyu, LI Tao, LI Xiaobin, LI Yunmeng, QIU Yaqi, YAN Fayu, WU Hairong, YUAN Dong, WANG Yongli, LIU Wentao. Effects of Nicotinamide on Rumen Fermentation Parameters,Microbial Protein Yield and Microflora in Lactating Dairy Cows [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(2): 593-604.
[5]	LI Jinnan, WANG Yahui, DENG Tianyu, LIANG Mang, DU Lili, LI Keanning, XUE Qingqing, QIAN Li, GAO Xue, ZHANG Lupei, ZHU Bo, CHEN Yan, WANG Zezhao, LI Junya, GAO Huijiang. Cloning,Bioinformatics Analysis and Tissue Expression Profile of Coding Region of Bovine MED28 Gene [J]. China Animal Husbandry & Veterinary Medicine, 2024, 51(8): 3225-3236.
[6]	YAO Weijia, LUO Chunhai, LIU Jiajin, WANG Wei, LI Danyang, LIU Bingqi, FU Shixin. Effect of Overexpression of miRNA-424-5p Targeting AKT3 on Apoptosis of Endometrial Epithelial Cells in Dairy Cows [J]. China Animal Husbandry & Veterinary Medicine, 2024, 51(8): 3635-3642.
[7]	HE Xingli, ZHOU Peiyao, ZHANG Xiaoxue, MOU Quanzhou, LI Yang, WANG Zhaoyuan, LIU Peng, WANG Zi, SONG Yangyang, LI Xiaolin, SHEN Binglei. Effect of Staphylococcus aureus and Staphylococcus epidermidis on the Secretion of Inflammatory Factors by Neutrophils in Dairy Cows [J]. China Animal Husbandry & Veterinary Medicine, 2024, 51(8): 3676-3686.
[8]	JI Guoshang, SHENG Hui, ZHANG Junxing, FENG Xue, HU Chunli, WANG Yachun, MA Yanfen, LI Li, YANG Wenfei, MA Yun. Study on the Function of PCYOX1L Gene Regulating LPS-induced Bovine Endometrial Epithelial Cells [J]. China Animal Husbandry & Veterinary Medicine, 2024, 51(7): 2984-2997.
[9]	MA Xiaoxue, LONG Rui, NIU Yujie, GUO Hongyong, LUO Ruiqing, WU Yanyan, ZHANG Wenju. Effect of Adding Isoacids in Perinatal Diet on Rumen Fermentation Parameters, Rumen Microorganisms and Production Performance of Dairy Cows [J]. China Animal Husbandry & Veterinary Medicine, 2024, 51(4): 1428-1437.
[10]	ZHANG Tenglong, GUO Chenyang, ZHONG Huachen, LIU Jialin, SONG Jie, WANG Lifang. Effects of Dandelion and Forsythia Extracts on Production Performance,Serum Antioxidant and Immune Indexes of Dairy Cows With Subclinical Mastitis [J]. China Animal Husbandry & Veterinary Medicine, 2024, 51(4): 1490-1499.
[11]	LUO Chunhai, ZHENG Chengyuan, ZHANG Menglong, YAO Weijia, LIU Jiajin, LIU Bingqi, WANG Wei, FU Shixin. Regulation of Vascular Endothelial Growth Factor A Expression by miRNA-185 in Dairy Cows with Retained Fetal Membranes [J]. China Animal Husbandry & Veterinary Medicine, 2024, 51(3): 916-925.
[12]	ZHANG Bo, GENG Yang, LI Tianzun, AO Yingnan, LU Yulai, WU Yinga, QI Zhili. Research Progress on the Mechanisms of Autophagy in Mastitis,Ketosis and Fatty Liver in Dairy Cows [J]. China Animal Husbandry & Veterinary Medicine, 2024, 51(12): 5218-5224.
[13]	WANG Xiaofang, WANG Yawen, LI Jiefeng, FU Le, ZHANG Ning, QIN Jianhua. Screening and Application Research of Traditional Chinese Medicine Formulas for Anti-heat Stress in Dairy Cows [J]. China Animal Husbandry & Veterinary Medicine, 2024, 51(11): 5064-5073.
[14]	WANG Fei, CHEN Tianyu, HAO Kebi, XU Yiming, ZHANG Hongxing, Yiliyaer, HOU Guobin, CUI Wenwen, ZHUANG Yimin, LIU Shuai, SHEN Yueyu, QI Yan, SHAO Wei, GUO Gang, CAO Zhijun. Effects of Feeding Immunomodulatory and Nutritional Combined Additive on Rumen Microflora and Metabolism of Transition Dairy Cows [J]. China Animal Husbandry & Veterinary Medicine, 2024, 51(10): 4255-4269.
[15]	QIU Qing, ZHAO Meng, WANG Dian, CHEN Yakun, ZHAO Liansheng, ZANG Changjiang. Nutritional Effects of 25-hydroxyvitamin D₃ on Primiparous and Mulitiparous Periparturient Dairy Cows [J]. China Animal Husbandry & Veterinary Medicine, 2024, 51(10): 4313-4323.