Abstract: Intestinal flora is an important part of animal body,and is closely related to parasites and host.Parasites infection often have an adverse effects on the host,and its pathogenicity are related to parasite species,parasitic sites and the interaction with the host.Parasites infection can lead to intestinal microecological changes,dysbiosis and inflammatory diseases.Intestinal flora also affects the colonization,proliferation and virulence of parasites in the host.Intestinal parasite include parasitic worms and protozoa.Studies on the interaction between intestinal parasites and flora in recent years have found that both protozoa and worms infection all can cause the changes of the composition and diversity of gut microbes and pathogenic effects on the host,and the potential therapeutic effect of helminth on inflammatory bowel disease once overturned people's understanding of parasites.The intestinal flora can promote or inhibit the pathogenic effect of the parasite on the host,and the probiotic has a certain preventive or therapeutic effect on the intestinal parasite infection.The research on the relationship between parasites and intestinal flora is still in the early stage,and the mechanism of its interaction is still unclear.Clarifying the interaction and mechanism between parasites and intestinal flora is of great significance for understanding the relationship between parasites,intestinal flora and the host,and developing effective anti-parasite microecologics.In this paper,the research progress of the interaction between intestinal worms and protozoa and microbiota in recent years is reviewed,and the future research directions in this field are prospected,which provide new strategies and theoretical basis for the prevention and control of parasitic diseases.

Key words: parasites; intestinal flora; host; interaction