丹皮酚生物学功能及其在畜禽抗炎中应用的研究进展

doi:10.16431/j.cnki.1671-7236.2025.09.039

摘要/Abstract

摘要： 丹皮酚(paeonol，Pae)是牡丹干燥根皮中的主要有效成分，具有抗炎、抗肿瘤、神经保护、心血管保护、代谢调节、镇痛及抑菌除螨等多种生物学功能，近年来因其多靶点、低毒性的特点，逐渐成为畜禽疾病防治领域的研究热点。丹皮酚能通过抑制核转录因子-κB(NF-κB)、有丝分裂原活化蛋白激酶(MAPK)等炎症信号通路，抑制促炎因子的表达，减轻炎症反应，在奶牛乳腺炎、鱼类炎症模型及畜禽关节炎等疾病中表现出良好的抗炎效果。同时，丹皮酚还具有抗肿瘤作用，通过诱导肿瘤细胞凋亡、抑制细胞增殖和迁移，对非小细胞肺癌、卵巢癌等肿瘤疾病具有潜在的治疗作用。在神经保护和心血管保护方面，丹皮酚通过抑制神经细胞凋亡、调节神经炎症反应，缓解帕金森病等神经退行性疾病的症状，并通过抑制心肌细胞肥大、纤维化及氧化应激，减轻心血管疾病的病理损伤，改善犬急性心肌梗死模型中的心肌缺血程度，具有抗内皮细胞衰老和促进血栓再通的作用。此外，丹皮酚还具有调节代谢的功能，能改善糖尿病、高脂血症等代谢紊乱疾病，并通过调节胰岛素水平和脂质代谢，缓解相关并发症。在畜禽抗炎领域，丹皮酚的应用研究主要集中在关节炎、肺炎、结肠炎、皮炎、神经炎、牙周炎、急性胰腺炎及子宫内膜炎等疾病，研究表明其能通过抑制Toll样受体4(TLR4)/NF-κB信号通路、调节炎症细胞因子的表达、改善肠道微生物群落等多种机制缓解炎症反应。笔者通过对丹皮酚生物学功能及其在畜禽抗炎中的研究进展进行系统综述，以期为丹皮酚在兽医临床中的应用提供科学依据，并为其进一步开发为安全有效的天然药物提供参考。

关键词: 丹皮酚; 畜禽; 抗炎; 生物学功能

Abstract: Paeonol (Pae),the main active component derived from the dried root bark of Paeonia suffruticosa,exhibits a wide range of biological functions,including anti-inflammatory,anti-tumor,neuroprotective,cardiovascular protective,metabolic regulatory,analgesic,and antimicrobial effects.Due to its multi-target and low-toxicity characteristics,Pae has gradually become a research hotspot in the field of livestock and poultry disease prevention and treatment.Pae can alleviate inflammatory responses by inhibiting the NF-κB and MAPK signaling pathways and reducing the expression of pro-inflammatory factors,demonstrating significant anti-inflammatory effects in diseases such as bovine mastitis,fish inflammation models,and livestock arthritis.Meanwhile,Pae also exhibits anti-tumor properties by inducing tumor cell apoptosis and inhibiting cell proliferation and migration,showing potential therapeutic effects on non-small cell lung cancer,ovarian cancer,and other tumor-related diseases.In terms of neuroprotection and cardiovascular protection,Pae mitigates symptoms of neurodegenerative diseases such as Parkinson’s disease by inhibiting neuronal apoptosis and regulating neuroinflammatory responses,while also reducing pathological damage in cardiovascular diseases by suppressing myocardial cell hypertrophy,fibrosis,and oxidative stress,improving myocardial ischemia in canine acute myocardial infarction models,and exerting anti-endothelial cell aging and thrombolytic effects.Additionally,Pae has metabolic regulatory functions,improving metabolic disorders such as diabetes and hyperlipidemia by modulating insulin levels and lipid metabolism,thereby alleviating related complications.In the field of anti-inflammatory applications in livestock and poultry,research on Pae has focused on diseases such as arthritis,pneumonia,colitis,dermatitis,neuritis,periodontitis,acute pancreatitis,and endometritis.Studies have shown that Pae can alleviate inflammatory responses through multiple mechanisms,including the inhibition of the TLR4/NF-κB signaling pathway,regulation of inflammatory cytokine expression,and improvement of gut microbiota.This review systematically summarizes the biological functions of Pae and its research progress in anti-inflammatory applications in livestock and poultry,aiming to provide a scientific basis for its clinical application in veterinary medicine and promote its development as a safe and effective natural drug.

Key words: paeonol; livestock and poultry; anti-inflammatory; biological function

中图分类号:

S853.7

李刘慧, 郭方超, 周垠全, 王丫丫, 彭伟龙, 殷韶杰. 丹皮酚生物学功能及其在畜禽抗炎中应用的研究进展[J]. 中国畜牧兽医, 2025, 52(9): 4440-4452.

LI Liuhui, GUO Fangchao, ZHOU Yinquan, WANG Yaya, PENG Weilong, YIN Shaojie. Research Progress on Biological Function of Paeonol and Its Application in Clinical Anti-inflammatory of Livestock and Poultry[J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(9): 4440-4452.

参考文献

[1] 张树蓉,赵宏苏,佟沫儒,等.牡丹皮化学成分、药理作用及其质量标志物(Q-Marker)的预测分析[J].中草药,2022,53(16):5215-5224. ZHANG S R,ZHAO H S,TONG M R,et al.Chemical constituents,pharmacological effects of moutan cortex and predictive analysis on its quality marker (Q-Marker)[J].Chinese Traditional and Herbal Drugs,2022,53(16):5215-5224.(in Chinese)
[2] SHANG R,CHEN L,XIN Y,et al.Evaluation of rosmarinic acid on broiler growth performance,serum biochemistry,liver antioxidant activity,and muscle tissue composition[J].Animals (Basel),2022,12(23):3313.
[3] SHIN S,JOO S S,PARK D,et al.Ethanol extract of Angelica gigas inhibits croton oil-induced inflammation by suppressing the cyclooxygenase-prostaglandin pathway[J].Journal of Veterinary Science,2010,11(1):43-50.
[4] WU R,LIU Y,ZHANG F,et al.Protective mechanism of paeonol on central nervous system[J].Phytotherapy Research,2024,38(2):470-488.
[5] 杨明,李可,贾丽,等.丹皮酚对LPS诱导的奶牛乳腺上皮细胞炎性损伤的缓解作用[J].畜牧与兽医,2023,55(4):50-55. YANG M,LI K,JIA L,et al.Alleviation effect of paeonol on LPS-induced inflammatory injury in bovine mammary epithelial cells[J].Animal Husbandry & Veterinary Medicine,2023,55(4):50-55.(in Chinese)
[6] GU Y,CHEN K,XI B,et al.Protective effects of paeonol against lipopolysaccharide-induced liver oxidative stress and inflammation in gibel carp (Carassius auratus gibelio)[J].Comparative Biochemistry and Physiology.Toxicology & Pharmacology,2022,257:109339.
[7] ZHANG C,ZHANG J,GUO K.Paeonol upregulates expression of tumor suppressors TNNC1 and SCARA5,exerting anti-tumor activity in non-small cell lung cancer cells[J].Naunyn-Schmiedeberg’s Archives of Pharmacology,2024,397(7):5241-5251.
[8] CHEN X M,JIA C L,ZHU Z Y.Paeonol impacts ovarian cancer cell proliferation,migration,invasion and apoptosis via modulating the transforming growth factor beta/smad3 signaling pathway[J].Journal of Physiology and Pharmacology,2023,74(6)：655-667.
[9] LI S,ZHU F,ZYKOVA T,et al.T-LAK cell-originated protein kinase (TOPK) phosphorylation of MKP1 protein prevents solar ultraviolet light-induced inflammation through inhibition of the p38 protein signaling pathway[J].Journal of Biological Chemistry,2011,286(34):29601-29609.
[10] TAYANLOO-BEIK A,KIASALARI Z,ROGHANI M.Paeonol ameliorates cognitive deficits in streptozotocin murine model of sporadic Alzheimer’s disease via attenuation of oxidative stress,inflammation,and mitochondrial dysfunction[J].Journal of Molecular Neuroscience,2022,72(2):336-348.
[11] LI X,SHI H,ZHANG D,et al.Paeonol alleviates neuropathic pain by modulating microglial M1 and M2 polarization via the RhoA/p38MAPK signaling pathway[J].CNS Neuroscience & Therapeutics,2023,29(9):2666-2679.
[12] RAMAZI S,FAHANIK-BABAEI J,MOHAMADI-ZARCH S M,et al.Paeonol exerts neuroprotective and anticonvulsant effects in intrahippocampal kainate model of temporal lobe epilepsy[J].Journal of Chemical Neuroanatomy,2022,124:102121.
[13] LIU C,YI X,YAN J,et al.Paeonol improves angiotensin Ⅱ-induced cardiac hypertrophy by suppressing ferroptosis[J].Heliyon,2023,9(9):e19149.
[14] DING M,SHI R,FU F,et al.Paeonol protects against doxorubicin-induced cardiotoxicity by promoting Mfn2-mediated mitochondrial fusion through activating the PKCepsilon-Stat3 pathway[J].Journal of Advanced Research,2023,47:151-162.
[15] 郭齐,郝伟,王蕊,等.牡丹皮有效成分重组复方对犬实验性急性心肌梗死的影响[J].中国中医药信息杂志,2010,17(4):39-40. GUO Q,HAO W,WANG R,et al.Effects of reassociated complex prescription of effective constituent of Cortex Moutan on acute myocardial infarction in experimental canines[J].Chinese Journal of Information on Traditional Chinese Medicine,2010,17(4):39-40.(in Chinese)
[16] 陈蓓,连李斌.丹皮酚抑制Notch1/Jagged1信号通路对妊娠糖尿病大鼠糖代谢紊乱的改善作用[J].河北医药,2023,45(11):1632-1636. CHEN B,LIAN L B.Paeonol alleviates glucose metabolism disorder in gestational diabetes mellitus rats by inhibiting the Notch1/Jagged1 signaling pathway[J].Hebei Medical Journal,2023,45(11):1632-1636.(in Chinese)
[17] LIU M,GAO X,SHI M,et al.Paeonol could alleviate diabetes-related spermatogenic dysfunction via SIRT3-dependent redox rebalancing[J].Clinical and Translational Medicine,2024,14(2):e1585.
[18] ADKI K M,KULKARNI Y A.Paeonol attenuates retinopathy in streptozotocin-induced diabetes in rats by regulating the oxidative stress and polyol pathway[J].Frontiers in Pharmacology,2022,13:891485.
[19] MIAO J,LIU X,LIAO Y,et al.Paeonol enhances macrophage phagocytic function by modulating lipid metabolism through the P53-TREM2 axis[J].Frontiers in Pharmacology,2023,14:1214756.
[20] 赫锦锦,方东.徐长卿丹皮酚对骨癌痛大鼠镇痛作用的研究[J].中国药理学通报,2020,36(11):1526-1531. HE J J,FANG D.Analgesic effect of paeonol from Cynanchum paniculatum on bone cancer pain of rats[J].Chinese Pharmacological Bulletin,2020,36(11):1526-1531.(in Chinese)
[21] 焦美,雷建军,张志成,等.丹皮酚调控miR-21对骨癌痛大鼠的镇痛作用及对MAPK信号通路的影响[J].解剖科学进展,2021,27(4):453-457. JIAO M,LEI J J,ZHANG Z C,et al.Analgesic effect of paeonol regulation of miR-21 on bone cancer pain rats and its effect on MAPK signaling pathway[J].Progress of Anatomical Sciences,2021,27(4):453-457.(in Chinese)
[22] 周洪亮,王海丹,王泽琨,等.不同晶型丹皮酚的药动学及抗痛经作用研究[J].中南药学,2024,22(1):43-47. ZHOU H L,WANG H D,WANG Z K,et al.Pharmacokinetics and anti-dysmenorrheal effect of paeonol polymorphs[J].Central South Pharmacy,2024,22(1):43-47.(in Chinese)
[23] 邹茗惠.丹皮酚对椭圆食粉螨的抑杀作用及机理研究[D].芜湖：皖南医学院,2023. ZOU M H.Acaricidal activity and mechanism of paeonol against Aleuroglyphus ovatus (Acari:Acarida)[D].Wuhu：Wannan Medical College,2023.(in Chinese)
[24] 赵颖.丹皮酚抑制黄曲霉的分子机制研究[D].郑州：河南工业大学,2022. ZHAO Y.Research on the molecular mechanism of danpi phenol inhibiting Aspergillus flavus[D].Zhengzhou：Henan University of Technology,2022.(in Chinese)
[25] 黄利挂.丹皮酚抗炎衍生物的设计合成及其机制研究[D].重庆：西南大学,2017. HUANG L G.Design,synthesis and anti-inflammatory evaluation of paeonol derivatives[D].Chongqing：Southwest University,2017.(in Chinese)
[26] 蒋利锋.丹皮酚在骨性关节炎中的作用及其机制研究[D].杭州：浙江大学,2017. JIANG L F.The effect and corresponding molecular mechanisms of paeonol in osteoarthritis[D].Hangzhou：Zhejiang University,2017.(in Chinese)
[27] 肖志刚,杨志新,蔡毅,等.丹皮酚联合甲氨蝶呤对类风湿关节炎大鼠的改善效果[J].热带医学杂志,2023,23(5):647-651. XIAO Z G,YANG Z X,CAI Y,et al.Improvement effect of paeonol combined with methotrexate in rats with rheumatoid arthritis[J].Journal of Tropical Medicine,2023,23(5):647-651.(in Chinese)
[28] 杨小四,姚文兵,胡华麟,等.丹皮酚对佐剂性关节炎大鼠继发性炎症的作用[J].中成药,2022,44(9):3000-3004. YANG X S,YAO W B,HU H L,et al.The effect of paeonol on secondary inflammation in adjuvant induced arthritis rats[J].Chinese Traditional Patent Medicine,2022,44(9):3000-3004.(in Chinese)
[29] CHEN G,JIA P,YIN Z Y,et al.Paeonol ameliorates monosodium urate-induced arthritis in rats through inhibiting nuclear factor-kappaB-mediated proinflammatory cytokine production[J].Phytotherapy Research,2019,33(11):2971-2978.
[30] 李梅,欧大明,黄丽芳,等.丹皮酚对IL-1β诱导HFLS-RA的保护作用及相关机制研究[J].天津医药,2021,49(3):252-257. LI M,OU D M,HUANG L F,et al.The protective effect of paeonol on IL-1β induced inflammatory response of human fibroblastlike synoviocytes and rheumatoid arthritis[J].Tianjin Medical Journal,2021,49(3):252-257.(in Chinese)
[31] 吴琪,任婕.徐长卿丹皮酚对兔膝关节软骨细胞凋亡及相关基因的影响[J].湖北中医药大学学报,2016,18(2):11-14. WU Q,REN J.Effects of Cynanchum paeonol on apoptosis and related genes in rabbit knee cartilage[J].Journal of Hubei University of Chinese Medicine,2016,18(2):11-14.(in Chinese)
[32] 吴倩,任婕,吴琪,等.丹皮酚对蛋白聚糖诱导的小鼠关节炎模型骶髂关节滑膜细胞BMP-2、Cbfα1及Smad1 mRNA表达的影响[J].湖北中医药大学学报,2018,20(2):18-22. WU Q,REN J,WU Q,et al.Effect of paeonol on expression of BMP-2,Cbfα and Smad1 mRNA in synoviocytes of sacroiliac joint of proteoglycan-induced arthritis model in mice[J].Journal of Hubei University of Chinese Medicine,2018,20(2):18-22.(in Chinese)
[33] 杨小四,邵玉宝,李文昊,等.甲酰肽受体激活剂丹皮酚抑制类风湿关节炎的作用[J].中国药理学通报,2022,38(9):1320-1327. YANG X S,SHAO Y B,LI W H,et al.The inhibitory effect of formyl peptide receptor activator paeonol on rheumatoid arthritis[J].Chinese Pharmacological Bulletin,2022,38(9):1320-1327.(in Chinese)
[34] LIU N,FENG X,WANG W,et al.Paeonol protects against TNF-alpha-induced proliferation and cytokine release of rheumatoid arthritis fibroblast-like synoviocytes by upregulating FOXO3 through inhibition of miR-155 expression[J].Inflammation Research,2017,66(7):603-610.
[35] QIAN W,LI X,YANG M,et al.Antibacterial and anti-biofilm activities of paeonol against Klebsiella pneumoniae and Enterobacter cloacae[J].Biofouling,2021,37(6):666-679.
[36] 雷航.丹皮酚调控PPARγ对内毒素休克大鼠急性肺损伤的保护作用[D].广州：广州中医药大学,2016. LEI H.Danpi phenol regulates PPARγ protective effect on acute lung injury in endotoxic shock rats[D].Guangzhou：Guangzhou University of Traditional Chinese Medicine,2016.(in Chinese)
[37] ZHAO M,XIE X,XU B,et al.Paeonol alleviates ulcerative colitis in mice by increasing short-chain fatty acids derived from Clostridium butyricum[J].Phytomedicine,2023,120:155056.
[38] ZHENG J,LI H,ZHANG P,et al.Paeonol ameliorates ulcerative colitis in mice by modulating the gut microbiota and metabolites[J].Metabolites,2022,12(10)：956.
[39] 刘霞.丹皮酚对溃疡性结肠炎的治疗效果及机制研究[D].郑州：郑州大学,2017. LIU X.Therapeutic effect of paeonol on ulcerative colitis and its mechanism[D].Zhengzhou：Zhengzhou University,2017.(in Chinese)
[40] 刘博,张传凤,马克龙,等.基于STAT-3/NF-κB/ICAM-1通路探讨丹皮酚缓解小鼠结肠炎相关性结直肠癌的作用机制[J].安徽中医药大学学报,2021,40(1):88-92. LIU B,ZHANG C F,MA K L,et al.Mechanism of action of paeonol in alleviating colitis-related colorectal cancer in mice:An analysis based on the STAT-3/NF-κB/ICAM-1 pathway[J].Journal of Anhui University of Chinese Medicine,2021,40(1):88-92.(in Chinese)
[41] 曹男,马智,李昶,等.丹皮酚对溃疡性结肠炎小鼠的治疗作用及机制[J].解剖科学进展,2022,28(1):1-4. CAO N,MA Z,LI C,et al.Effect and mechanism of paeonol on ulcerative colitis in mice[J].Progress of Anatomical Sciences,2022,28(1):1-4.(in Chinese)
[42] GE Y,PAN M,ZHANG C,et al.Paeonol alleviates dextran sodium sulfate induced colitis involving Candida albicans-associated dysbiosis[J].Medical Mycology,2021,59(4):335-344.
[43] LIU Y,WU H,WANG T,et al.Paeonol reduces microbial metabolite alpha-hydroxyisobutyric acid to alleviate the ROS/TXNIP/NLRP3 pathway-mediated endothelial inflammation in atherosclerosis mice[J].Chinese Journal of Natural Medicines,2023,21(10):759-774.
[44] WANG Y,YUE Y,JIA R,et al.Design and evaluation of paeonol-loaded liposomes in thermoreversible gels for atopic dermatitis[J].Gels,2023,9(3):193.
[45] WANG Y,TANG Z,GUO X,et al.Hyaluronic acid-cyclodextrin encapsulating paeonol for treatment of atopic dermatitis[J].International Journal of Pharmaceutics,2022,623:121916.
[46] WANG W,LI Q,ZHAO Z,et al.Paeonol ameliorates chronic itch and spinal astrocytic activation via CXCR3 in an experimental dry skin model in mice[J].Frontiers in Pharmacology,2021,12:805222.
[47] HE L X,TONG X,ZENG J,et al.Paeonol suppresses neuroinflammatory eesponses in LPS-activated microglia cells[J].Inflammation,2016,39(6):1904-1917.
[48] CAI L,ZENG R,HUANG Q,et al.Paeonol inhibits chronic constriction injury-induced astrocytic activation and neuroinflammation in rats via the HDAC/miR-15a pathway[J].Drug Development Research,2022,83(8):1758-1765.
[49] 沈涛,徐远志,彭前,等.丹皮酚对牙龈卟啉单胞菌体外抗菌性的研究[J].中国医院用药评价与分析,2020,20(10):1171-1174. SHEN T,XU Y Z,PENG Q,et al.Research on in vitro antibacterial effect of paeonol on Porphyromonas gingivalis[J].Evaluation and Analysis of Drug-Use in Hospitals of China,2020,20(10):1171-1174.(in Chinese)
[50] LI J,LI Y,PAN S,et al.Paeonol attenuates ligation-induced periodontitis in rats by inhibiting osteoclastogenesis via regulating Nrf2/NF-kappaB/NFATc1 signaling pathway[J].Biochimie,2019,156:129-137.
[51] 季力同,熊吉东,刘博秀,等.丹皮酚注射液对急性胰腺炎模型大鼠血清炎性因子的影响[J].中医药导报,2019,25(2):39-42. JI L T,XIONG J D,LIU B X,et al.Effect of paeonol injection on serum inflammatory factors in rats with acute pancreatitis[J].Guiding Journal of Traditional Chinese Medicine and Pharmacy,2019,25(2):39-42.(in Chinese)
[52] 张鹏,李俞甫,吴尚泽,等.丹皮酚对L-精氨酸诱导的小鼠急性胰腺炎氧化损伤的影响[J].畜牧兽医学报,2021,52(7):1983-1990. ZHANG P,LI Y F,WU S Z,et al.Effects of paeonol on the oxidative damage of acute pancreatitis in mice induced by L-arginine[J].Acta Veterinaria et Zootechnica Sinica,2021,52(7):1983-1990.(in Chinese)
[53] ZHANG P,YIN X,WANG X,et al.Paeonol protects against acute pancreatitis by Nrf2 and NF-kappaB pathways in mice[J].Journal of Pharmacy and Pharmacology,2022,74(11):1618-1628.
[54] YUAN C,XU X,WANG N,et al.Paeonol protects against acute pancreatitis by inhibiting M1 macrophage polarization via the NLRP3 inflammasomes pathway[J].Biochemical and Biophysical Research Communications,2022,600:35-43.
[55] 刘海涛.丹皮酚治疗奶牛子宫内膜炎的效果研究[D].泰安：山东农业大学,2021. LIU H T.Study on the therapeutic effect of paeonol on bovine endometritis[D].Tai’an：Shandong Agricultural University,2021.(in Chinese)
[56] 孙兰,刘莉娜,李家春,等.丹皮酚对LPS诱导小鼠子宫内膜炎NF-κB信号通路的影响[J].免疫学杂志,2019,35(11):960-964. SUN N,LIU L N,LI J C,et al.Paeonol attenuates LPS-induced endometritis in mice via inhibiting NF-κB signal pathway[J].Immunological Journal,2019,35(11):960-964.(in Chinese)
[57] 吴琪,吴倩,周晓红,等.丹皮酚对强直性脊柱炎模型小鼠Wnt和BMP/Smad信号转导通路的影响[J].中国药房,2018,29(11):1500-1504. WU Q,WU Q,ZHOU X H,et al.Effects of paeonol on Wnt and BMP/Smad signal transduction pathway in the ankylosing spondylitis model mice[J].China Pharmacy,2018,29(11):1500-1504.(in Chinese)
[58] 邢伟,李鹏飞,付海平,等.丹皮酚通过调节Wnt途径对强直性脊柱炎小鼠疗效及滑膜组织中RANKL和Smadl水平的影响[J].临床和实验医学杂志,2020,19(2):118-121. XING W,LI P F,FU H P,et al.Effects of paeonol on the efficacy of AS mice and the levels of RANKL and Smadl in synovial tissue by regulating Wnt pathway[J].Journal of Clinical and Experimental Medicine,2020,19(2):118-121.(in Chinese)
[59] 郑家春,熊正罡,赵洋洋,等.丹皮酚对强直性脊柱炎小鼠跟腱滑膜的影响[J].中国矫形外科杂志,2021,29(11):1019-1023. ZHENG J C,XIONG Z G,ZHAO Y Y,et al.The effect of paeonol on the synovial membrane of the achilles tendon in mice with ankylosing spondylitis[J].Orthopedic Journal of China,2021,29(11):1019-1023.(in Chinese)
[60] QI J H,DONG F X,WANG X L.Exploring targets and signaling pathways of paeonol involved in relieving inflammation based on modern technology[J].Molecular Diversity,2022,26(3):1731-1742.
[61] 许海棠,廖华珍,周菊英,等.载丹皮酚纳米纤维膜的制备、表征及性能评价[J].中草药,2023,54(14):4493-4500. XU H T,LIAO H Z,ZHOU J Y,et al.Preparation,characterization and performance evaluation of nanofiber membranes loaded with paeonol[J].Chinese Traditional and Herbal Drugs,2023,54(14):4493-4500.(in Chinese)
[62] 张荣发.环糊精衍生物对丹皮酚包合特性研究[D].重庆：重庆大学,2009. ZHANG R F.Study on inclusion compound of cyclodextrin derivatives and paeonol[D].Chongqing：Chongqing University,2009.(in Chinese)
[63] 徐爱霞,杨传红,王海龙.丹皮酚明胶微球的制备及质量评价[J].药学研究,2017,36(10):589-591. XU A X,YANG C H,WANG H L.Preparation and quality evaluation of paeonolum gelatin microspheres[J].Journal of Pharmaceutical Research,2017,36(10):589-591.(in Chinese)
[64] 赵吉平,邹从早,马海平.丹皮酚固体分散体制备表征及体外溶出特性[J].中国医药科学,2020,10(9):35-38. ZHAO J P,ZOU C Z,MA H P.Preparation characterization and in vitro dissolution of paeonol solid dispersion[J].China Medicine and Pharmacy,2020,10(9):35-38.(in Chinese)
[65] 王乙颖,张必荣,张志军,等.天然产物丹皮酚的衍生物开发利用研究[J].江苏调味副食品,2022,3:4-6. WANG Y Y,ZHANG B R,ZHANG Z J,et al.Development and utilization of derivatives of natural product paeonol[J].Jiangsu Condiment and Subsidiary Food,2022,3:4-6.(in Chinese)