基于抗毒力策略的表没食子儿茶素没食子酸酯抗菌作用研究进展

doi:10.16431/j.cnki.1671-7236.2025.07.041

摘要/Abstract

摘要： 随着细菌耐药性问题的日益严重，兽医临床上的细菌性疾病变得更加棘手，开发新型抗感染药物刻不容缓。为避免传统抗生素的选择性压力引起的细菌耐药，针对细菌毒力因子的抗毒力策略已成为一种新的抗菌方案。黄酮类化合物表没食子儿茶素没食子酸酯(epigallocatechin gallate，EGCG)，具有多羟基、酯化修饰、立体构型等特有结构，可与细菌毒力因子结合，对多种细菌的毒力因子均具有抑制作用，是理想的抗毒力药物。笔者就EGCG的抗毒力策略进行综述，概述了EGCG理化性质与药理作用，阐明了该化合物主要通过直接结合毒力因子、阻碍毒力基因表达、阻止毒力因子分泌和间接抗毒力作用途径抑制细菌毒力，探讨了EGCG对不同种类毒力因子(内毒素、溶血素、肠毒素、酶类、生物被膜及毒力调控系统)的抑制作用及机制，并从临床治疗角度探讨了EGCG开发成为抗毒力药物的应用前景和面临的问题，旨在为兽医领域新型抗毒力药物的研究提供理论依据，通过抗毒力策略促进畜牧业的健康可持续发展。

关键词: 表没食子儿茶素没食子酸酯(EGCG); 毒力因子; 细菌; 抑制作用

Abstract: With the increasingly serious problem of bacterial drug resistance,bacterial diseases in veterinary clinical practice have become more intractable,and the development of novel anti-infective drugs is extremely urgent.The anti-virulence strategy targeting bacterial virulence factors has become a promising antibacterial approach to avoid the selective pressure-induced resistance associated with conventional antibiotics.The flavonoid epigallocatechin gallate (EGCG), with its unique structures such as polyhydroxy,esterification modification,and stereoconfiguration,can bind to bacterial virulence factors and has inhibitory effects on the virulence factors of various bacteria. It is an ideal anti-virulence drug.The author reviewed the anti-virulence strategies of EGCG,summarized the physicochemical properties and pharmacological effects of EGCG,and clarified that this compound mainly inhibits bacterial virulence through direct binding to virulence factors,hindering the expression of virulence genes,preventing the secretion of virulence factors,and indirect anti-virulence action pathways.The inhibitory effects and mechanisms of EGCG on different types of virulence factors (endotoxin,hemolysin,enterotoxin,enzymes,biofilms and virulence regulatory systems) were further summarized and explored.From the perspective of clinical treatment,the application prospects and problems faced by the development of EGCG into an anti-virulence drug were discussed,aiming to provide a theoretical basis for the research of novel anti-virulent drugs in the veterinary field and promote the healthy and sustainable development of animal husbandry through anti-virulence strategies.

Key words: epigallocatechin gallate(EGCG); virulence factor; bacteria; inhibition

中图分类号:

S854.5^＋3

王涛, 薛可, 张国铖, 徐子易, 彭掁洋, 梁喜才, 崔子寅, 夏志强, 张泽辉. 基于抗毒力策略的表没食子儿茶素没食子酸酯抗菌作用研究进展[J]. 中国畜牧兽医, 2025, 52(7): 3429-3439.

WANG Tao, XUE Ke, ZHANG Guocheng, XU Ziyi, PENG Chengyang, LIANG Xicai, CUI Ziyin, XIA Zhiqiang, ZHANG Zehui. Research Progress on Antibacterial Effect of Epigallocatechin Gallate Based on Anti-virulence Strategy[J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(7): 3429-3439.

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