Abstract: Paeonol (Pae),the main active component derived from the dried root bark of Paeonia suffruticosa,exhibits a wide range of biological functions,including anti-inflammatory,anti-tumor,neuroprotective,cardiovascular protective,metabolic regulatory,analgesic,and antimicrobial effects.Due to its multi-target and low-toxicity characteristics,Pae has gradually become a research hotspot in the field of livestock and poultry disease prevention and treatment.Pae can alleviate inflammatory responses by inhibiting the NF-κB and MAPK signaling pathways and reducing the expression of pro-inflammatory factors,demonstrating significant anti-inflammatory effects in diseases such as bovine mastitis,fish inflammation models,and livestock arthritis.Meanwhile,Pae also exhibits anti-tumor properties by inducing tumor cell apoptosis and inhibiting cell proliferation and migration,showing potential therapeutic effects on non-small cell lung cancer,ovarian cancer,and other tumor-related diseases.In terms of neuroprotection and cardiovascular protection,Pae mitigates symptoms of neurodegenerative diseases such as Parkinson’s disease by inhibiting neuronal apoptosis and regulating neuroinflammatory responses,while also reducing pathological damage in cardiovascular diseases by suppressing myocardial cell hypertrophy,fibrosis,and oxidative stress,improving myocardial ischemia in canine acute myocardial infarction models,and exerting anti-endothelial cell aging and thrombolytic effects.Additionally,Pae has metabolic regulatory functions,improving metabolic disorders such as diabetes and hyperlipidemia by modulating insulin levels and lipid metabolism,thereby alleviating related complications.In the field of anti-inflammatory applications in livestock and poultry,research on Pae has focused on diseases such as arthritis,pneumonia,colitis,dermatitis,neuritis,periodontitis,acute pancreatitis,and endometritis.Studies have shown that Pae can alleviate inflammatory responses through multiple mechanisms,including the inhibition of the TLR4/NF-κB signaling pathway,regulation of inflammatory cytokine expression,and improvement of gut microbiota.This review systematically summarizes the biological functions of Pae and its research progress in anti-inflammatory applications in livestock and poultry,aiming to provide a scientific basis for its clinical application in veterinary medicine and promote its development as a safe and effective natural drug.

Key words: paeonol; livestock and poultry; anti-inflammatory; biological function