拷贝数变异在畜禽中的研究进展

doi:10.16431/j.cnki.1671-7236.2021.07.027

Abstract

Abstract: Copy number variation (CNV) has many forms of variation structure,which plays an important role in the study of variety diversity,biological evolution and disease correlation,and has the characteristics of large fragment length and wide coverage.With the development of molecular biology and the maturity of DNA sequencing technology,the study of genetic variation has been deepened to the DNA molecular level.Polymorphic markers have gradually become the trend and mainstream of animal breeding research in livestock and poultry breeding.As CNV has more significant effects on gene regulation and expression,there are more and more studies on CNV in important livestock and poultry.At present,a large number of gene sequence variations related to important economic traits of livestock and poultry have been detected,and many studies have shown that CNV is related to the important economic characteristics of animals and the occurrence of diseases.By referring to the relevant research reports at home and abroad,the author briefly introduced the related research background,concept and mutation mechanism of CNV,and summarizes the effects of CNV on economic traits,reproductive traits and disease regulation of cattle,sheep,pig and chickens.in order to reveal the genetic mechanism of adaptability and the genetic basis of phenotypic traits through the genomic research on these important livestock and poultry,and to develop corresponding molecular genetic markers.To provide a theoretical basis for marker-assisted breeding of livestock and poultry.

Key words: copy number variations(CNV); livestock and poultry; production traits

CLC Number:

S813

JING Zhenzhu, QIN Panpan, CHEN Bingjie, HOU Dan, WEI Chengjie, LI Tong, HAN Ruili, LIU Xiaojun, TIAN Yadong, KANG Xiangtao, LI Zhuanjian. Research Progress of Copy Number Variation in Livestock and Poultry[J]. China Animal Husbandry & Veterinary Medicine, 2021, 48(7): 2512-2522.

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Research Progress of Copy Number Variation in Livestock and Poultry

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