Abstract: Porcine deltacoronavirus (PDCoV) is a newly discovered enteropathogenic porcine Coronavirus causing severe diarrhea,vomiting,and dehydration,which leads to death eventually,posing a severe threat to the pig industry.Further research on PDCoV is of great significance for the prevention and control of this disease.The genome encodes four structural proteins,fifteen non-structural proteins and three accessory proteins play important roles in the virus replication,translation and the host pathogenic process.The pathogenesis of PDCoV is complicated.In this review,we summarized the pathogenesis from the aspects of its invading host cells,antagonising interferon response,inducing apoptosis,regulating autophagy,inhibiting pyroptosis to evade host immune response,and other molecular mechanisms affecting PDCoV replication.PDCoV shows a global epidemic trend,and S,M, N genes of PDCoV are often used as nucleic acid detection and antibody detection targets for diagnosis.So far,there are no effective vaccines and therapeutic methods available for PDCoV.With the development of biotechnology,the research on inactivated vaccines,live attenuated vaccines,recombined vector vaccines,virus-like particle vaccines and lactic acid bacteria carries oral vaccines have made considerable progress.In addition,broad spectrum antiviral drugs,antiviral proteins and new antiviral technologies have shown good application prospects in PDCoV antiviral research.Therefore,this review comprehensively expounded its coding protein function,pathogenicity,detection methods,vaccine development and antiviral therapy,hoping to provide reference for further systematic research and effective prevention and control.

Key words: pigs; Porcine deltacoronavirus (PDCoV); pathogenesis; prevention and control