新城疫病毒样颗粒研究进展

doi:10.16431/j.cnki.1671-7236.2022.04.033

Abstract

Abstract: Newcastle disease (ND) is an acute,highly contagious avian infectious disease caused by Newcastle disease virus (NDV),with respiratory,digestive and nervous system symptoms as the main characteristics,the mortality rate in susceptible poultry is as high as 100%,which has brought serious economic losses to poultry breeding and trade in China and the world.Virus-like particles (VLPs) are virus-like protein particles that are formed by in vitro expression or spontaneous assembly of viral proteins during the infection process,which do not contain viral genome,cannot replicate,and have no infectious ability.The suitable size and unique surface structure of VLPs can be effectively recognized by natural immune cells and molecules,and induce good innate and adaptive immune responses.In addition,VLPs do not contain viral infectious nucleic acids and are highly safe.In recent years,they have become a research hotspot in the field of vaccines.Dendritic cells (DCs),as full-time antigen-presenting cells,have a unique function between innate immunity and adaptive immunity,and are currently the full-time immune cells with the strongest antigen-presenting ability.Migration of mature DCs (mDCs) to secondary lymphoid tissues can stimulate the activation and proliferation of primary T cells,and is considered to be the initiator of specific immune responses.Immature DCs (imDCs) cultured in vitro can also help enhance the ability of antigen presentation.NDV-VLPs mainly use NDV-M protein as the backbone to assemble HN,F and NP proteins,which can show similar appearance and immunogenicity to live NDV particles.It can be seen that vaccines made by NDV-VLPs also have many advantages,such as safety,stability,stimulating humoral and cellular immune responses,expressing other antigens as carriers,and being designed to distinguish natural infections from immunization.Therefore,the article mainly discusses the related content of NDV-VLPs in order to provide reference for follow-up research.

Key words: Newcastle disease virus (NDV); virus-like particles (VLPs); dendritic cells; vaccine

CLC Number:

S852.65^＋7

CHI Shanshan, JIA Weijuan, HE Yunjiang, MENG Qinglei, CHEN Yunjiao, WANG Xueli. Research Progress on Newcastle Disease Virus-like Particles[J]. China Animal Husbandry & Veterinary Medicine, 2022, 49(4): 1507-1515.

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Research Progress on Newcastle Disease Virus-like Particles

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