Abstract: Two different kinds of antibiotic-free addictive were added to the growing pigs' diet to explore their effects on growth and intestinal health.Sixty LDY crossbred pigs at the weight of (85.95±3.48) kg were selected and divided into control group,groups 1 and 2 with 5 replicates in each group and 4 pigs in each replicate (half of castrated boars and half of sows).The pigs in control group were fed with basal diet,in group 1 were fed with 0.5% Monascus yeast selenium germanium complex preparation,and in group 2 were fed with 0.5% compound Chinese medicine extract in the basic diet.The results showed that:①There was no significant difference in growth performance among the three groups (P>0.05).②Compared with the control group,the villus height(VH) of jejunum,villus height/crypt depth(V/H) and villus height of ileum were significantly increased in group 1 (P<0.05),villus height of jejunum and ileum in group 2 were significantly increased (P<0.05).Villus height of jejunum and ileum in group 1 were significantly higher than that in group 2 (P<0.05).③Compared with the control group,the Shannon index of cecal flora in groups 1 and 2 were significantly increased (P<0.05),and the Simpson index were significantly decreased (P<0.05).The Shannon index of group 1 was significantly higher than that of group 2 (P<0.05).④At the phylum level,compared with the control group,the abundance of Proteobacteria and Actinobacteria were significantly increased (P<0.05),and the abundance of Firmicutes was significantly decreased (P<0.05) in group 1.The abundance of Firmicutes and Proteobacteria were significantly increased (P<0.05),and the abundance of Bacteroidetes was significantly decreased (P<0.05) in group 2.The abundance of Actinobacteria in group 1 was significantly higher than that of group 2,and the abundance of Firmicutes in group 1 was significantly lower than that of group 2.At the genus level,compared with the control group,the abundance of Streptococcus was significantly increased (P<0.05),and the abundance of Turicibacter,uncultured_bacterium_f_Muribaculaceae and Lactobacillus were significantly decreased (P<0.05) in group 1.The abundance of Ruminococcaceae_UCG-005 and Streptococcus were significantly increased (P<0.05),and the abundance of Turicibacter,Clostridium_sensu_stricto_13 and Lactobacillus were significantly decreased (P<0.05) in group 2.The abundance of Clostridium_sensu_stricto_13 and Streptococcus in group 1 was significantly higher than that of group 2 (P<0.05),the abundance of Uncultured_bacterium_f_Muribaculaceae and Ruminococcaceae_UCG-005 in group 1 were significantly lower than that of group 2 (P<0.05).⑤ In group 1,the expression of Occludin,ZO-1 and Claudin-1 were significantly higher than the control group (P<0.05),and the expression of Occludin and Claudin-1 were significantly higher than group 2 (P<0.05).The above results showed that both the Monascus yeast selenium germanium complex preparation and compound Chinese medicine extract could improve the intestinal health of growing pigs,and the feeding effect of Monascus group was better.

Key words: antibiotic-free addictive; growing pigs; growth performance; intestinal health