China Animal Husbandry & Veterinary Medicine ›› 2020, Vol. 47 ›› Issue (7): 2005-2012.doi: 10.16431/j.cnki.1671-7236.2020.07.005
• Physiology and Biochemistry • Previous Articles Next Articles
LIU Yadan, WANG Haizhen, LIU Juan, WANG Shu, ZUO Zhou, CAI Chunbo, GUO Xiaohong, CAO Guoqing, LI Bugao, GAO Pengfei
Received:
2019-12-23
Online:
2020-07-20
Published:
2020-07-18
CLC Number:
LIU Yadan, WANG Haizhen, LIU Juan, WANG Shu, ZUO Zhou, CAI Chunbo, GUO Xiaohong, CAO Guoqing, LI Bugao, GAO Pengfei. Research Advance on Intestinal Microflora and Its Regulatory Factors of Piglets[J]. China Animal Husbandry & Veterinary Medicine, 2020, 47(7): 2005-2012.
[1] DUBOS R,SCHAEDLER R W,COSTELLO R,et al.Indigenous,normal,and autochthonous flora of the gastrointestinal tract[J].Journal of Experimental Medicine,1965,122(1):67-76. [2] SAVAGE D C.Microbial ecology of the gastrointestinal tract[J].Annual Reviews in Microbiology,1977,31(1):107-133. [3] CUMMINGS J H,MACFARLANE G T.Colonic microflora:Nutrition and health[J].Nutrition,1997,13(5):476-478. [4] ROBERFROID M,BORNET F,BOULEY C E,et al.Colonic microflora:Nutrition and health[J].Nutrition,1995,53(5):127-130. [5] CHOCT M.Managing gut health through nutrition[J].British Poultry Science,2009,50(1):9-15. [6] CHERVONSKY A V.Influence of microbial environment on autoimmunity[J].Nature Immunology,2010,11(1):28-35. [7] HOOPER L V,LITTMAN D R,MACPHERSON A J.Interactions between the microbiota and the immune system[J].Science,2012,336(6086):1268-1273. [8] 祁玉丽,孙印石,李珊珊.植物多糖对肠道微生态的作用研究进展[J].中国微生态学杂志,2018,30(4):489-494. QI Y L,SUN Y S,LI S S.Research progress of plant polysaccharides on intestinal microbiome[J].Chinese Journal of Microecology,2018,30(4):489-494.(in Chinese) [9] 杨利娜,边高瑞,朱伟云,等.单胃动物肠道微生物菌群与肠道免疫功能的相互作用[J].微生物学报,2014,54(5):480-486. YANG L N,BIANG G R,ZHU W Y,et al.Interactions between the microbiota and the intestinal monogastric animal gut immune function:A review[J].Acta Microbiologica Sinica,2014,54(5):480-486.(in Chinese) [10] CASTILLO M,MART N-OR E S,ANGUITA M,et al.Adaptation of gut microbiota to corn physical structure and different types of dietary fibre[J].Livestock Science,2007,109(1-3):149-152. [11] ABRIOUEL H,BENOMAR N,COBO A,et al.Characterization of lactic acid bacteria from naturally-fermented Manzanilla Aloreña green table olives[J].Food Microbiology,2012,32(2):308-316. [12] LITVAK Y,BYNDLOSS M X,TSOLIS R M,et al.Dysbiotic Proteobacteria expansion:A microbial signature of epithelial dysfunction[J].Current Opinion in Microbiology,2017,39(10):1-6. [13] ARENAS-PADILLA M,DUARTE-GUTI RREZ J L,MATA-HARO V.Bifidobacterium animalis ssp.lactis Bb12 induces IL-10 through cell membrane-associated components via TLR 2 in swine[J].Journal of Applied Microbiology,2018,125(6):1881-1889. [14] YANG J,QIAN K,WANG C,et al.Roles of probiotic lactobacilli inclusion in helping piglets establish healthy intestinal inter-environment for pathogen defense[J].Probiotics and Antimicrobial Proteins,2018,10(2):243-250. [15] ZHANG W,MA C,XIE P,et al.Gut microbiota of newborn piglets with intrauterine growth restriction have lower diversity and different taxonomic abundances[J].Journal of Applied Microbiology,2019,127(2):354-369. [16] YANG Q,HUANG X,ZHAO S,et al.Structure and function of the fecal microbiota in diarrheic neonatal piglets[J].Environmental Microbiology,2017,8(3):502-515. [17] BAN-TOKUDA T,MAEKAWA S,MIWA T,et al.Changes in faecal bacteria during fattening in finishing swine[J].Anaerobe,2017,47(10):188-193. [18] FANG S,XIONG X,SU Y,et al.16S rRNA gene-based association study identified microbial taxa associated with pork intramuscular fat content in feces and cecum lumen[J].BMC Microbiology,2017,17(1):162-171. [19] CHEN X,XU J,REN E,et al.Co-occurrence of early gut colonization in neonatal piglets with microbiota in the maternal and surrounding delivery environments[J].Anaerobe,2018,49(2):30-40. [20] 李德发.猪的营养[M].北京:中国农业大学出版社,2003. LI D F.Nutrition of Pigs[M].Beijing:China Agricultural University Press,2003.(in Chinese) [21] PLUSKE J.Invited review:Aspects of gastrointestinal tract growth and maturation in the pre-and postweaning period of pigs[J].Journal of Animal Science,2016,94(3):399-411. [22] SPLICHALOVA A,SLAVIKOVA V,SPLICHALOVA Z,et al.Preterm life in sterile conditions:A study on preterm,germ-free piglets[J].Frontiers in Immunology,2018,9(2):220-232. [23] DE GOFFAU M C,LAGER S,SOVIO U,et al.Human placenta has no microbiome but can contain potential pathogens[J].Nature,2019,1(7):329-334. [24] 宋连喜,鄂禄祥,高明,等.猪和兔胚胎胃肠道菌群的初步研究[J].中国兽医杂志,2007,43(10):24-26. SONG L X,E L X,GAO M,et al.Preliminary study on gastrointestinal flora of pig and rabbit embryos[J].Chinese Journal of Veterinary Medicine,2007,43(10):24-26.(in Chinese) [25] UNDERWOOD M A,GILBERT W M,SHERMAN M P.Amniotic fluid:Not just fetal urine anymore[J].Journal of Perinatology,2005,25(5):341-348. [26] JOST T,LACROIX C,BRAEGGER C P,et al.Vertical mother-neonate transfer of maternal gut bacteria via breastfeeding[J].Environmental Microbiology,2014,16(9):2891-2904. [27] DOMINGUEZ-BELLO M G,COSTELLO E K,CONTRERAS M,et al.Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns[J].Proceedings of the National Academy of Sciences,2010,107(26):11971-11975. [28] CHEN W,MI J,LV N,et al.Lactation stage-dependency of the sow milk microbiota[J].Frontiers in Microbiology,2018,9(5):945-957. [29] MART N V,MALDONADO-BARRAG N A,MOLES L,et al.Sharing of bacterial strains between breast milk and infant feces[J].Journal of Human Lactation,2012,28(1):36-44. [30] WIYAPORN M,THONGSONG B,KALANDAKANOND-THONGSONG S.Growth and small intestine histomorphology of low and normal birth weight piglets during the early suckling period[J].Livest Science,2013,158(1-3):215-222. [31] WANG X,TSAI T,DENG F,et al.Longitudinal investigation of the swine gut microbiome from birth to market reveals stage and growth performance associated bacteria[J].Microbiome,2019,7(1):109-127. [32] ZENG M,INOHARA N,NU EZ G.Mechanisms of inflammation-driven bacterial dysbiosis in the gut[J].Mucosal Immunology,2017,10(1):18-26. [33] ALAIN B P E,CHAE J P,BALOLONG M P,et al.Assessment of fecal bacterial diversity among healthy piglets during the weaning transition[J].Journal of General & Applied Microbiology,2014,60(4):140-146. [34] WANG T,TENG K,LIU G,et al.The functions and mechanisms of microecological agents in weaning piglet intestine[J].Scientin Sinica Vitae,2019,49(2):97-107. [35] LI Y,GUO Y,WEN Z,et al.Weaning stress perturbs gut microbiome and its metabolic profile in piglets[J].Scientific Reports,2018,8(1):1-12. [36] WANG X,TSAI T,DENG F,et al.Longitudinal investigation of the swine gut microbiome from birth to market reveals stage and growth performance associated bacteria[J].Microbiome,2019,7(1):109-127. [37] PARKER A,LAWSON M A,VAUX L,et al.Host-microbe interaction in the gastrointestinal tract[J].Environmental Microbiology,2018,20(7):2337-2353. [38] CHEN L,XU Y,CHEN X,et al.The maturing development of gut microbiota in commercial piglets during the weaning transition[J].Frontiers in Microbiology,2017,8(9):1-13. [39] MATHEW A,ROBBINS C,CHATTIN S,et al.Influence of galactosyl lactose on energy and protein digestibility,enteric microflora,and performance of weanling pigs[J].Journal of Animal Science,1997,75(4):1009-1016. [40] MURASE K,WATANABE T,ARAI S,et al.Characterization of pig saliva as the major natural habitat of Streptococcus suis by analyzing oral,fecal,vaginal,and environmental microbiota[J].PLoS One,2019,14(4):e0215983. [41] ZHAO W,WANG Y,LIU S,et al.The dynamic distribution of porcine microbiota across different ages and gastrointestinal tract segments[J].PLoS One,2015,10(2):1-13. [42] WU G D,CHEN J,HOFFMANN C,et al.Linking long-term dietary patterns with gut microbial enterotypes[J].Science,2011,334(6052):105-108. [43] ZHANG L,MU C,HE X,et al.Effects of dietary fibre source on microbiota composition in the large intestine of suckling piglets[J].FEMS Microbiology Letters,2016,363(14):1-6. [44] METZLER B,MOSENTHIN R.A review of interactions between dietary fiber and the gastrointestinal microbiota and their consequences on intestinal phosphorus metabolism in growing pigs[J].Asian-Australasian Journal of Animal Sciences,2008,21(4):603-615. [45] LIU B,WANG W,ZHU X,et al.Response of gut microbiota to dietary fiber and metabolic interaction with SCFAs in piglets[J].Frontiers in Microbiology,2018,9(28):23-44. [46] LUO Y,CHEN H,YU B,et al.Dietary pea fibre alters the microbial community and fermentation with increase in fibre degradation-associated bacterial groups in the colon of pigs[J].Journal of Animal Physiology and Animal Nutrition,2018,102(1):e254-e261. [47] CHENG G,HAO H,XIE S,et al.Antibiotic alternatives:The substitution of antibiotics in animal husbandry?[J].Frontiers in Microbiology,2014,5(217):1-15. [48] 杨伟平,王建刚,曹斌云.猪肠道微生物群落组成变化及其影响因素[J].中国畜牧杂志,2017,53(1):12-16. YANG W P,WANG J G,CAO B Y.Composition and influence factors of pigs' gut microbial community[J].Chinese Journal of Animal Science,2017,53(1):12-16.(in Chinese) [49] MIKKELSEN M S,JENSEN M G,NIELSEN T S.Barley beta-glucans varying in molecular mass and oligomer structure affect cecal fermentation and microbial composition but not blood lipid profiles in hypercholesterolemic rats[J].Food & Function,2017,8(12):4723-4732. [50] 陈庆菊,刘金艳,卢昌文,等.饲粮添加β-葡聚糖对断奶仔猪生长性能和肠道微生物区系的影响[J].动物营养学报,2018,30(11):4712-4720. CHEN Q J,LIU J Y,LU C W,et al.Effects of dietary β-glucan on growth performance and intestinal microflora of weaned piglets[J].Chinese Journal of Animal Nutrition,2018,30(11):4712-4720.(in Chinese) [51] 吴俊,许二学,刘强.日粮添加异麦芽寡糖对断奶仔猪生长性能、抗氧化和免疫性能及肠道微生物含量的影响[J].中国饲料,2018,29(12):46-50. WU J,XU E X,LIU Q,et al.Effects of dietary supplementation of isomalto oligosaccharide on growth performance,antioxidant capacity,immunity and gut microbiota of weaning pigs[J].China Feed,2018,29(12):46-50.(in Chinese) [52] 崔艺燕,马现永.酵母多糖的生物学功能及其对仔猪肠道健康的影响[J].动物营养学报,2018,30(3):857-864. CUI Y Y,MA X Y.Biological function of yeast polysaccharide and its effect on piglet's gut health[J].Chinese Journal of Animal Nutrition,2018,30(3):857-864.(in Chinese) [53] LI P,NIU Q,WEI Q,et al.Microbial shifts in the porcine distal gut in response to diets supplemented with Enterococcus Faecalis as alternatives to antibiotics[J].Scientific Reports,2017,7(2):1-10. [54] 刘颖,王海斌,周刚,等.抗生素对仔猪肠道微生物的影响[J].动物营养学报,2017,29(8):2912-2922. LIU Y,WANG H B,ZHOU G,et al.Effects of antibiotics on intestinal microorganisms of piglets[J].Chinese Journal of Animal Nutrition,2017,29(8):2912-2922.(in Chinese) [55] YU M,MU C,YANG Y,et al.Increases in circulating amino acids with in-feed antibiotics correlated with gene expression of intestinal amino acid transporters in piglets[J].Amino Acids,2017,49(9):1587-1599. [56] NEUMAN H,FORSYTHE P,UZAN A,et al.Antibiotics in early life:Dysbiosis and the damage done[J].FEMS Microbiology Reviews,2018,42(4):489-499. [57] 姚浪群,萨仁娜,佟建明,等.安普霉素对仔猪肠道微生物及肠壁组织结构的影响[J].畜牧兽医学报,2003,34(3):250-257. YAO L Q,SA R N,Tong J M,et al.Effect of apramycin on intestinal flora and intestinal morphology of piglets[J].Journal of Animal Husbandry and Veterinary Medicine,2003,34(3):250-257.(in Chinese) [58] LIN J,HUNKAPILLER A A,LAYTON A C,et al.Response of intestinal microbiota to antibiotic growth promoters in chickens[J].Foodborne Pathogens & Disease,2013,10(4):331-337. [59] KUANG Y,WANG Y,ZHANG Y,et al.Effects of dietary combinations of organic acids and medium chain fatty acids as a replacement of zinc oxide on growth,digestibility and immunity of weaned pigs[J].Animal Feed Science & Technology,2015,208(5):145-157. [60] ZHU C,LV H,CHEN Z,et al.Dietary zinc oxide modulates antioxidant capacity,small intestine development,and jejunal gene expression in weaned piglets[J].Biological Trace Element Research,2017,175(2):331-338. [61] 彭鹏,陈思佳,蒋再慧,等.多孔氧化锌对断奶仔猪粪便中微量元素含量,盲肠内容物与粪便中短链脂肪酸含量及肠道菌群多样性的影响[J].动物营养学报,2018,30(12):5221-5229. PENG P,CHEN S J,JIANG Z H,et al.Effects of porous zinc oxide on fecal microelement contents,short chain fatty acid contents in cecum content and feces and intestinal bacterial diversity of weaned piglets[J].Chinese Journal of Animal Nutrition,2018,30(12):5221-5229.(in Chinese) [62] 梅绍锋.高铜对断奶仔猪的促生长和微生态效应研究[D].雅安:四川农业大学,2009. MEI S F.Study on the growth promoting and microecological effects of high copper on weaned piglets[D].Ya'an:Sichuan Agricultural University,2009.(in Chinese) [63] CHENG S,MAO H,RUAN Y,et al.Copper changes intestinal microbiota of the cecum and rectum in female mice by 16S rRNA gene sequencing[J].Biological Trace Element Research,2019,5(1):1-11. [64] 孔祥杰,姜海龙,蔡维北,等.黄芪茎叶对断奶仔猪盲肠微生物区系的影响[J].中国畜牧杂志,2017,53(3):117-120. KONG X J,JIANG H L,CAI W B,et al.Effect of astragalus stem plant on the microflora in gut of weaned piglets[J].Chinese Journal of Animal Science,2017,53(3):117-120.(in Chinese) [65] YE G,QIU Y,HE X L,et al.Effect of two macrocephala flavored powder supplementation on intestinal morphology and intestinal microbiota in weaning pigs[J].International Journal of Clinical & Experimental Medicine,2015,8(1):1504-1514. [66] MICHIELS J,MISSOTTEN J A M,FREMAUT D,et al.In vitro characterisation of the antimicrobial activity of selected essential oil components and binary combinations against the pig gut flora[J].Animal Feed Science & Technology,2009,151(1):111-127. [67] 姚继明,孟秀丽,吕锋,等.复合有机酸酸化剂对断奶仔猪生长性能及其肠道微生物菌群的影响[J].饲料工业,2017,38(2):11-16. YAO J M,MENG X L,LYU F,et al.The influences of compound organic acid acidifier on the growth performance and intestinal flora of weaned piglets[J].Feed Industry,2017,38(2):11-16.(in Chinese) |
[1] | RUAN Shihui, LIU Chunyan, WEI Yangyang, HE Yiyi, WU Qiwen, XIONG Yunxia, YANG Xuefen, WANG Li, YI Hongbo. Effect of PDCoV on the Extracellular Matrix of the Intestine and Its Dynamic Changes in Weaned Piglets [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(7): 3297-3307. |
[2] | REN Hao, ZHU Yixuan, CHAO Tingting, WANG Xiaoyi, LU Shaoxiong, YANG Yongli, CHEN Qiang, LI Mingli. Identification and Functional Prediction of lncRNA in Longissimus Dorsi Muscle of Saba Pigs with Different Growth Rates [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(6): 2494-2505. |
[3] | YU Miao, LI Yanjiao, ZHAO Yanling, CHAO Zhe, WANG Feng, LI Menghan, JIANG Zhiqiang, ZHANG Ting, XUE Xinyu, REN Zili, SUN Ruiping. Effects of Weaning Stress on Intestinal Morphology, Antioxidant Capacity and Nrf2 Signaling Pathway of Wuzhishan Piglets [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(5): 2045-2055. |
[4] | WU Min, XU Junjie, LI Xinxin, CHEN Yifan, WANG Dehe, HAO Erying, CHEN Hui, SHI Lei. Screening of Key Genes Regulating Muscle Development in Yellow-feathered Chickens Based on RNA-Seq [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(3): 990-1000. |
[5] | HU Xiaodi, ZHEN Wenrui, BAI Dongying, ZHONG Jiale, ZHANG Ruilin, ZHANG Haojie, ZHANG Yi, MA Yanbo. Interactions and Their Mechanisms Between Stress and Poultry Intestinal Microbiota [J]. China Animal Husbandry & Veterinary Medicine, 2024, 51(6): 2471-2480. |
[6] | WANG Suwan, FENG Xiaofang, TONG Lijia, LI Desheng, WANG Yu, FENG Yuan, JIANG Qiufei, XU Jun, CHEN Yafei, GU Yaling, ZHANG Juan. Genetic Parameter Estimation of Growth and Developmental Traits in Angus Cattle During Weaning Stage [J]. China Animal Husbandry & Veterinary Medicine, 2024, 51(6): 2517-2523. |
[7] | WU Yuxing, ZOU Weili, CHENG Zixin, MO Yupeng, ZHANG Lingyuan, JI Wantong, CHEN Siyu, ZHENG Haodong, MA Runwen, LI Xun, LI Maoning, WANG Xiaoye. Isolation, Identification and Pathogenicity Analysis of a Strain of Swine-derived Clostridium perfringens Type A [J]. China Animal Husbandry & Veterinary Medicine, 2024, 51(6): 2697-2706. |
[8] | YANG Zhikang, YIN Yunju, XU Weiwei, CHEN Guang, ZHENG Mengli, YAN Zhaoming, LIU Yating, ZHANG Guanfeng, PENG Jie, JIANG Huiqiong, HU Youjun, ZHAO Xiaonan, CHEN Qinghua. Effects of Organic Acid Combined with Essential Oil,Tannic Acid and Compound Enzyme Preparation on Growth Performance,Serum Biochemical Indexes and Intestinal Heath of Weaned Piglets [J]. China Animal Husbandry & Veterinary Medicine, 2024, 51(3): 978-989. |
[9] | ZHAO Xiaonan, HU Youjun, CHENG Huangzuo, WEN Wei, LU Xinfang, HE Zishi, CHEN Jiemei, E Xiaodi, HE Qiantai, ZOU Tiande. Effects of Different Types of Benzoic Acid on Growth Performance, Serum Biochemical Indices and Intestinal Flora of Weaned Piglets [J]. China Animal Husbandry & Veterinary Medicine, 2024, 51(3): 1031-1040. |
[10] | JIANG Bingyu, CHEN Ning, CUI Yanan, ZHU Kaiqing, JIANG Pengxin, WANG Xutao, LI Yan. Investigation of the Mechanism of Sihuang Antidiarrheal Granules in the Treatment of Piglets Diarrhea Based on Network Pharmacology and Molecular Docking [J]. China Animal Husbandry & Veterinary Medicine, 2024, 51(3): 1308-1319. |
[11] | SUN Pengfei, WANG Xiaohan, HU Yun, WU Huiguang, ZHAO Jingwen, LUO Xugang. Research Advances on the Effects of Heat Stress on Production Performance, Serum Biochemistry and Gut Microbes in Chickens [J]. China Animal Husbandry & Veterinary Medicine, 2024, 51(2): 581-590. |
[12] | WEI Haibo, LIU Yingchun, SUN Shuguang, LIU Xiwu, ZHU Guihua, DAI Zhenghao, LIU Zongzheng, WEN Fengyun. Effects of Dietary Probiotics and Acid Preparations on Growth Performance and Intestinal Flora of Weaned Piglets [J]. China Animal Husbandry & Veterinary Medicine, 2024, 51(12): 5302-5316. |
[13] | PAN Chenglin, SONG Tongxing, ZHANG Xiaojun, LOU Fangfang, HU Xujin, TU Pingguang, XIAO Yingping, LYU Wentao. Study on the Structure and Function of the Archaea Community and Its Correlation with Diarrhea of Weaned Piglets [J]. China Animal Husbandry & Veterinary Medicine, 2024, 51(11): 4755-4764. |
[14] | ZHANG Hong, TIAN Qiufeng, ZOU Yue, YIN Junyi, BAI Changsheng, HUANG Yuxiang, WANG Zhiqiang, MA Zhigang, HUO Mingdong, DONGJiaqiang, YANG Haotian, YANG Kun, MIAO Yan, CHEN Zhifeng. Isolation,Identification and Probiotic Characteristics of Streptococcus alactolyticus from Intestinal Tract of Zi Geese [J]. China Animal Husbandry & Veterinary Medicine, 2024, 51(10): 4578-4586. |
[15] | LI Hongyi, YANG Xuefen, LIN Zesen, WU Xiaofei, LYU Qixin, YU Jiali, ZHANG Mao. Effect of Lactobacillus reuteri Replacing Antibiotics on the Expression of Intestinal miRNA in Piglets [J]. China Animal Husbandry & Veterinary Medicine, 2024, 51(1): 74-85. |
Viewed | ||||||
Full text |
|
|||||
Abstract |
|
|||||