白藜芦醇的生物学功能及其在动物生产中的应用

doi:10.16431/j.cnki.1671-7236.2019.11.012

Abstract

Abstract: Resveratrol is a natural non-flavonoid polyphenolic compound containing a quinone structure.It has various biological functions,including inhibiting and eliminating excess free radicals in body,activating the body's antioxidant enzyme system and exerting antioxidant function.By regulating a series of inflammatory or anti-inflammatory pathways,it can reduce the expression of inflammatory factors in the body and the inflammatory response.Resveratrol also has important biological functions such as regulating glycolipid metabolism,protecting cardiovascular,anti-cancer,anti-virus,etc.It has the advantages of safety,high efficiency,no residue,no drug resistance,and has broad application prospects in animal production.Animal experiments show that resveratrol can increase the average daily gain,average feed intake,and feed to gain ratio of broilers.It also can improve the quality of fattening pork,increase the longissimus dorsi muscle,pH_{24 h},redness,crude protein and myoglobin The compound can also reduce muscle brightness after 24 h,shear force,drip loss and backfat thickness,increase antioxidant enzyme activity in animal body,reduce inflammatory factor production,enhance immunity and improve intestinal flora composition and mucosal morphology,inhibits the formation of cancer cells.The authors will review the biological characteristics,physiological functions of resveratrol and its application status in order to provide reference for its application in livestock and poultry production.

Key words: resveratrol; antioxidant; anti-inflammatory; intestinal tract

CLC Number:

TQ463

MA Yujing, HE Rongxiang, YANG Ling, HE Jianhua. The Biological Function of Resveratrol and Its Application in Animal Production[J]. China Animal Husbandry & Veterinary Medicine, 2019, 46(11): 3234-3243.

References

[1] TAKAOKA M.Phenolic substance of white hellebore (Veratrum grandiflorum Loes fil.).Ⅲ.Constitution ofresveratrol[J].Nippon Kagaku Kaishi,1940,61:30-34.
[2] 张卫兵.白藜芦醇和血根碱对犊牛生长发育、瘤胃发酵和肝脏基因表达的影响[D].北京:中国农业科学院,2018. ZHANG W B.Effects of resveratrol and sanguinarine on growth,rumen fermentation,and liver gene expression of calves[D].Beijing:Chinese Academy of Agricultural Sciences,2018.(in Chinese)
[3] MAR M I F,MATEOS R,PARRILLA M C G,et al.Bioactive compounds in wine:Resveratrol,hydroxytyrosol and melatonin:A review[J]. Food Chemistry,2012,130(4):797-813.
[4] BAUR J A.Resveratrol improves health and survival of mice on a high-calorie diet[J].Nature,2006,7117(444):337-342.
[5] KRISHNA P L B,JOHN M P.Cancer chemopreventive activity of resveratrol[J]. Drugs under Experimental and Clinical Research,1999,25(2-3):65-77.
[6] ZHUO F D,JIA W C,YU S,et al.Resveratrol promotes nerve regeneration via activation of p300 acetyltransferase-mediated VEGF signaling in a rat model of sciatic nerve crush injury[J].Frontiers in Neuroscience,2018,12:341.
[7] MAGYAR K.Cardioprotection by resveratrol:A human clinical trial in patients with stable coronary artery disease[J].Clinical Hemorheology and Microcirculation,2012,3(50):179-187.
[8] YONAMINE C Y,MACHADO E P,MARI L M,et al.Resveratrol improves glycemic control in type 2 diabetic obese mice by regulating glucose transporter expression in skeletal muscle and liver[J].Molecules,2017,22(7):1180.
[9] 李先宽,李赫宇,李帅,等.白藜芦醇研究进展[J].中草药,2016,47(14):2568-2578. LI X K,LI H Y,LI S,et al.Advances in study on resveratrol[J].Chinese Traditional and Herbal Drugs,2016,47(14):2568-2578.(in Chinese)
[10] FREMONT L.Biological effects of resveratrol[J]. Life Sciences,2000,8(66):663-673.
[11] 幸程鸿.白藜芦醇对FLHS蛋鸡卵巢氧化应激和炎症因子的调控机制[D].南昌:江西农业大学,2017. XING C H.The regulatory mechanism of resveratrol in oxidative stress and inflammatory in ovaries of FLHS hens[D].Nanchang:Jiangxi Agricultural University,2017.(in Chinese)
[12] 叶舒.白藜芦醇对FLHS蛋鸡肝脏氧化应激及炎症的调控作用[D].南昌:江西农业大学,2017. YE S.The regulatory effects of resveratrol on oxidative stress and inflammation in liver of FLHS laying hens[D].Nanchang:Jiangxi Agricultural University,2017.(in Chinese)
[13] 王俊文.饲粮添加白藜芦醇对接种蓝耳病弱毒苗育肥猪生产性能和免疫功能及肉品质的影响[D].雅安:四川农业大学,2012. WANG J W.Effects of dietary supplementation of resveratrol on performance and immune response and meat quality of finishing pigs under PRRS MLV challenge[D].Ya'an:Sichuan Agricultural University,2012.(in Chinese)
[14] 王虹玲,吴优,于子箫,等.酿酒葡萄皮渣中白藜芦醇的提取及抗氧化、抗肿瘤活性研究[J].中国酿造,2018,37(7):112-116. WANG H L,WU Y,YU Z X,et al.Extraction,antioxidant and antitumor activities of resveratrol from wine grape pomace[J] China Brewing,2018,37(7):112-116.(in Chinese)
[15] QING W M,TAO G,GAO Q L,et al.Dietary resveratrol improves antioxidant status of sows and piglets and regulates antioxidant gene expression in placenta by Keap1-Nrf2 pathway and Sirt1[J].Journal of Animal Science and Biotechnology,2018,9:34.
[16] EUN K,JI H L,MIN K,et al.Resveratrol,an Nrf2 activator,ameliorates aging-related progressive renal injury[J].Aging,2018,10(1):83-99.
[17] UNGVARI Z,BAGI Z,FEHER A,et al.Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2[J].American Journal of Physiology Heart and Circulatory Physiology,2010,299(1):18-24.
[18] UNGVARI Z,OROSZ Z,RIVERA A,et al.Resveratrol increases vascular oxidative stress resistance[J].American Journal of Physiology-Heart and Circulatory Physiology,2007,292(5):2417-2424.
[19] MENG Z,LI J,ZHAO H,et al.Resveratrol relieves ischemia-induced oxidative stress in the hippocampus by activating SIRT1[J].Experimental and Therapeutic Medicine,2015,10(2):525-530.
[20] 邓颖,张雄,胡红.白藜芦醇后处理通过PI3K/Akt/Nfr2上调HO-1对大鼠心肌I/R的保护研究[J].重庆医学,2018,47(9):1176-1178. DENG Y,ZHANG X,HU H.Study on protective effect of resveratrol post-treatment on rat myocardial I/R injury through up-regulating HO-1 via PI3K/Akt/Nfr2[J].Chongqing Medicine,2018,47(9):1176-1178.(in Chinese)
[21] HOU Y Y,WANG K,WAN W J,et al.Resveratrol provides neuroprotection by regulating the JAK2/STAT3/PI3K/AKT/mTOR pathway after stroke in rats[J].Genes & Diseases,2018,5(3):245-255.
[22] HYUNG S Y,JOO Y L,KATHERINE A F,et al.Specific inhibition of MyD88-independent signaling pathways of TLR3 and TLR4 by resveratrol:Molecular targets are TBK1 and RIP1 in TRIF complex[J].The Journal of Immunology,2005,175(5):3339-3346.
[23] 胡瑶莲,张恒志,陈代文,等.白藜芦醇对生长育肥猪抗氧化能力、空肠黏膜免疫及结肠菌群的影响[J].动物营养学报,2019,31(1):459-468. HU Y L,ZHANG H Z,CHEN D W,et al.Effects of resveratrol on antioxidant capacity,jejunal mucosal immunity and colonic microflora of growing-finishing pigs[J].Chinese Journal of Animal Nutrition,2019,31(1):459-468.(in Chinese)
[24] RAHAL K.Resveratrol has antiinflammatory and antifibrotic effects in the peptidoglycan-polysaccharide rat model of Crohn's disease[J]. Inflammatory Bowel Diseases,2012,4(18):613-623.
[25] DUN Q X,YAN L,BO Z,et al.Resveratrol alleviate hypoxic pulmonary hypertension via anti-inflammation and anti-oxidant pathways in rats[J].International Journal of Medical Sciences,2016,13(12):942-954.
[26] MU X,CHENGZ G,DING Z F,et al.Resveratrol enhances IL-4 receptor-mediated anti-inflammatory effects in spinal cord and attenuates neuropathic pain following sciatic nerve injury[J].Molecular Pain,2018,14:1744806918767549.
[27] MANNA S K.Resveratrol suppresses TNF-induced activation of nuclear transcription factors NF-kappa B,activator protein-1,and apoptosis:Potential role of reactive oxygen intermediates and lipid peroxidation[J].Journal of Immunology,2000,12(164):6509-6519.
[28] ASHIKAWA K.Piceatannol inhibits TNF-induced NF-kappaB activation and NF-kappaB-mediated gene expression through suppression of IkappaBalpha kinase and p65 phosphorylation[J]. Journal of Immunology,2002,11(169):6490-6497.
[29] 胡博,张颖,田野,等.炎症因子与椎间盘退变的关系研究进展[J].中国脊柱脊髓杂志,2014,24(7):651-654. HU B,ZHANG Y,TIAN Y,et al.Research progress on the relationship between the inflammatory factors and intervertebral degeneration[J].Chinese Journal of Spine and Spinal Cord,2014,24(7):651-654.(in Chinese)
[30] 王春喜.沉默信息调节因子1在实验性脑出血后继发性脑损伤中的作用研究[D].南京:南京大学,2015. WANG C X.The role of silent information regulator 1(SIRT1) in second brain injury after experimental intracerebral hemorrhage[D].Nanjing:Nanjing University,2015.(in Chinese)
[31] ZHU J.Anti-inflammatory effect of resveratrol on TNF-alpha-induced MCP-1 expression in adipocytes[J].Biochemical and Biophysical Research Communications,2008,369(2):471-477.
[32] REN Z H.Resveratrol inhibits NF-κB signaling through suppression of p65 and IkappaB kinase activities[J]. Die Pharmazie,2013,68(8):689-694.
[33] 王光熙.白藜芦醇的抗炎活性及其介TLR4/NFκBp65/MAPKs信号通路发挥抗炎效应的机制研究[D].雅安:四川农业大学,2017. Wang G X.Anti-inflammatory effect of resveratrol and it mintigates lipopolysaccharide-mediated acute inflammation in rats by inhibiting the TLR4/NFκBp65/MAPKs signaling cascade[D].Ya'an:Sichuan Agricultural University,2017.(in Chinese)
[34] OLHOLM J,PAULSEN S K,CULLBERG K B,et al.Anti-inflammatory effect of resveratrol on adipokine expression and secretion in human adipose tissue explants[J].International Journal of Obesity,2010,34(10):1546-1553.
[35] KAUPPINEN A.Antagonistic crosstalk between NF-κB and SIRT1 in the regulation of inflammation and metabolic disorders[J].Cellular Signalling,2013,25(10):1939-1948.
[36] YI C O,BYEONGTAK J,HYUN J S,et al.Resveratrol activates AMPK and suppresses LPS-induced NF-κB-dependent COX-2 activation in RAW 264.7 macrophage cells[J].Advances in Anatomy Embryology and Cell Biology,2011,44(3):194-203.
[37] PARK S J.Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases[J].Cell,2012,148(3):421-433.
[38] 魏晶,王青筠,王颖,等.白藜芦醇抑制哮喘幼鼠肺组织Sirt1与AMPK的表达[J].解剖科学进展,2018,24(6):573-576. WEI J,WANG Q Y,WANG Y,et al.Resveratrol inhibits the expression of Sirt1 and AMPK in lung tissue of the asthmatic mice[J] Progress of Anatom Ical Sciences,2018,24(6):573-576.(in Chinese)
[39] SARA F,MIRKO P,ALESSIO F,et al.Biological effect of licochalcone C on the regulation of PI3K/Akt/eNOS and NF-κB/iNOS/NO signaling pathways in H9c2 cells in response to LPS stimulation[J].International Journal of Molecular Sciences,2017,18(4):690.
[40] OLHA L,IHOR S,ANNA M,et al.Vitamin D₃ protects against prednisolone-induced liver injury associated with the impairment of hepatic NF-κB/iNOS/nitric oxide pathway[J].Biochemistry and Cell Biology,2016,95(2):213-222.
[41] HUANG T C,LU K T,LU Y Y P,et al.Resveratrol protects rats from Aβ-induced neurotoxicity by the reduction of iNOS expression and lipid peroxidation[J].PLoS One,2011,6(12):e29102.
[42] HUANG T,GAO D,JIANG X F,et al.Resveratrol inhibits oxygen-glucose deprivation-induced MMP-3 expression and cell apoptosis in primary cortical cells via the NF-κB pathway[J]. Molecular Medicine Reports,2014,10(2):1065-1071.
[43] 王晓光,齐晓非,李戈辉.白藜芦醇抑制小肠再灌注继发肺损伤中38MAPK通路及下游凋亡、炎症、氧化应激分子的表达[J].海南医科大学学报,2017,23(12):12-15. WANG X G,QI X F,LI G H.Resveratrol inhibits the P38MAPK pathway as well as downstream apoptosis,inflammation and oxidative stress molecule expression in secondary lung injury after intestinal ischemia-reperfusion[J].Journal of Hainan Medical University,2017,23(12):12-15.(in Chinese)
[44] KANG S S.Synthesis and biological evaluation of a library of resveratrol analogues as inhibitors of COX-1,COX-2 and NF-kappaB[J]. Bioorganic & Medicinal Chemistry,2009,3(17):1044-1054.
[45] PHAM M T A.Antinociceptive effect of resveratrol in carrageenan-evoked hyperalgesia in rats:Prolonged effect related to COX-2 expression impairment[J].Pain,2008,140(2):274-283.
[46] SERRA D.Resveratrol modulates cytokine-induced Jak/STAT activation more efficiently than 5-aminosalicylic acid:An in vitro approach[J]. PLoS One,2014,10(9):e109048.
[47] 左培培.白藜芦醇在脂多糖诱导的肝癌细胞增殖和侵袭转移中的作用[D].郑州:郑州大学,2016. ZUO P P.The effects of resveratrol on proliferation,invasion and metastasis of human hepatocellular carcinoma cells induced by lipopolysaccharide[D].Zhengzhou:Zhengzhou University,2016.(in Chinese)
[48] SCHNEIDER Y.Resveratrol inhibits intestinal tumorigenesis and modulates host-defense-related gene expression in an animal model of human familial adenomatous polyposis[J].Nutrition and Cancer,2001,39(1):102-107.
[49] RAJIV K J,MA Q Y,SHA H C.The protective effect of resveratrol on the intestinal mucosal barrier in rats with severe acute pancreatitis[J].Medical Science Monitor,2007,14(1):14-19.
[50] LING K H,MURPHY L Y W,HANI E N,et al.Protective capacity of resveratrol,a natural polyphenolic compound,against deoxynivalenol-induced intestinal barrier dysfunction and bacterial translocation[J].Chemical Research in Toxicology,2016,29(5):823-833.
[51] WANG N,HAN Q,WANG G,et al.Resveratrol protects oxidative stress-induced intestinal epithelial barrier dysfunction by upregulating heme oxygenase-1 expression[J].Digestive Diseases and Sciences,2016,61(9):2522-2534.
[52] 高润颖,蔡美琴.白藜芦醇对肠道保护作用的研究进展[J].上海交通大学学报(医学版),2016,36(2):302-306. GAO R Y,CAI M Q.Research advances in protective effect of resveratrol on intestine[J]. Journal of Shanghai Jiaotong University(Medical Science),2016,36(2):302-306.(in Chinese)
[53] BERESWILL S.Anti-inflammatory effects of resveratrol,curcumin and simvastatin in acute small intestinal inflammation[J].PLoS One,2010,12(5):e15099.
[54] WEN P D,FAN F L,ZHI G P,et al.Resveratrol ameliorates subacute intestinal ischemia-reperfusion injury[J].Journal of Surgical Research,2013,185(1):182-189.
[55] CIANCIULLI A.Modulation of NF-κB activation by resveratrol in LPS treated human intestinal cells results in downregulation of PGE2 production and COX-2 expression[J].Toxicology in Vitro,2012,7(26):1122-1128.
[56] MARIA A P,VITO C,ANGELA A,et al.Anti-inflammatory effects of resveratrol occur via inhibition of lipopolysaccharide-induced NF-κB activation in Caco-2 and SW480 human colon cancer cells[J].The British Journal of Nutrition,2012,108(9):1623-1632.
[57] 柯少凡,刘风,朱状辉.白藜芦醇通过保护线粒体和减少氧化应激改善失血性休克大鼠肠损伤[J].中南大学学报(医学版),2014,39(12):1259-1265. KE S F,LIU F,ZHU Z H.Resveratrol improves intestinal injury in hemorrhagic shock rats by protecting of mitochondria and reduction of oxidative stress[J]. Journal of Central South University (Medical Sciences),2014,39(12):1259-1265.(in Chinese)
[58] 张旭东,李旭炯,何玉婷,等.白藜芦醇对梗阻性黄疸大鼠肠道黏膜的保护作用[J].长治医学院学报,2017,31(1):1-4. ZHANG X D,LI X J,HE Y T,et al.Protection effect of resveratrol on intestine mucosa in rats with obstructive jaundice[J]. Journal of Changzhi Medical College,2017,31(1):1-4.(in Chinese)
[59] PATRICIA G,PHYLLISSA S R,JASON S M,et al.Resveratrol causes cell cycle arrest,decreased collagen synthesis,and apoptosis in rat intestinal smooth muscle cells[J].American Journal of Physiology.Gastrointestinal and Liver Physiology,2012,302(3):326-335.
[60] LI P,LING M L,ZHU Y,et al.Resveratrol inhibits collagen Ⅰ synthesis by suppressing IGF-1R activation in intestinal fibroblasts[J].World Journal of Gastroenterology,2014,20(16):4648-4661.
[61] VITRAC X.Distribution of[14C]-trans-resveratrol,a cancer chemopreventive polyphenol,in mouse tissues after oral administration[J].Life Sciences,2003,20(72):2219-2233.
[62] QIAO Y,SUN J,XIA S F,et al.Effects of resveratrol on gut microbiota and fat storage in a mouse model with high-fat-induced obesity[J].Food & Function,2014,5(6):1241-1249.
[63] 张健波,朱娜萍,陈洁,等.白藜芦醇对肠易激综合征大鼠脑源性神经营养因子系统表达的影响[J].温州医科大学学报,2018,48(3):178-184. ZHANG J B,ZHU N P,CHEN J,et al.The effect of resveratrol on the expression of brain-derived neurotrophic factor in rats with irritable bowel syndrome[J].Journal of Wenzhou Medical University,2018,48(3):178-184.(in Chinese)
[64] 刘丽莉.白藜芦醇对乌骨鸡热应激损伤的修复机制研究[D].长沙:湖南农业大学,2014. LIU L L.Research on the repair mechanisms of resveratrol to heat stress-induced damages in Black-boned chicken[D].Changsha:Hunan Agricultural University,2014.(in Chinese)
[65] ZHANG C,WANG L,ZHAO X H,et al.Dietary resveratrol supplementation prevents transport-stress-impaired meat quality of broilers through maintaining muscle energy metabolism and antioxidant status[J].Poultry Science,2017,96(7):2219-2225.
[66] AHMED S T,HOSSAIN M E,K G M,et al.Effects of resveratrol and essential oils on growth performance,immunity,digestibility and fecal microbial shedding in challenged piglets[J]. Asian-Australasian Journal of Animal Sciences,2013,26(5):683-690.
[67] 张卫兵,张蓉,毕研亮,等.白藜芦醇和血根碱对2~6月龄犊牛生长性能和血清生化指标的影响[J].畜牧兽医学报,2018,49(9):1940-1951. ZHANG W B,ZHANG R,BI Y L,et al.Effects of resveratrol and sanguinarine on growth performance and blood biochemical indices of 2-6 months old calves[J].Chinese Journal of Animal and Veterinary Sciences,2018,49(9):1940-1951.(in Chinese)
[68] 董婧,王洋,郭锦晓,等.白藜芦醇强化卤虫对斑马鱼肠道的形态结构和抗氧化能力的影响[J].沈阳农业大学学报,2016,47(4):488-492. DONG J,WANG Y,GUO J X,et al.Effects of resveratrol enriched artemia on intestinal morphology and anti-oxidative capacities of zebrafish (Barchuydanio rerio)[J] Journal of Shenyang Agricultural University,2016,47(4):488-492.(in Chinese)
[69] WHITNEY N W,BRADLEY L B,WADE O W,et al.Effects of resveratrol on growth and skeletal muscle physiology of juvenile southern flounder[J].Comparative Biochemistry and Physiology,2015,183:27-35.
[70] ZHANG C,LUO J Q,YU B,et al.Dietary resveratrol supplementation improves meat quality of finishing pigs through changing muscle fiber characteristics and antioxidative status[J].Meat Science,2015,102:15-21.
[71] FENG Z H,GONG G J,ZHAO G X,et al.Effects of dietary supplementation of resveratrol on performance,egg quality,yolk cholesterol and antioxidant enzyme activity of laying hens[J].British Poultry Science,2017,58(5):544-549.
[72] 张彩云,康相涛.白藜芦醇对肉仔鸡抗氧化能力和肉品质的影响[J].江苏农业学报,2011,27(3):587-591. ZHANG C Y,KANG X T.Effects of dietary resveratrol on antioxidant ability and meat quality in broilers[J].Jiangsu Journal of Agricultural Sciences,2011,27(3):587-591.(in Chinese)
[73] JUAN M E.Trans-resveratrol,a natural antioxidant from grapes,increases sperm output in healthy rats[J].The Journal of Nutrition 2005,135(4):757-760.
[74] 宋太玉.白藜芦醇对贡氏假鳃鳉免疫器官、淋巴细胞及免疫因子增龄性的影响[D].济南:山东师范大学,2016. SONG T Y.Effects of resveratrol on age related changes of immune organs,lymphocytes and immune parameters in the annual fish Nothobranchius guentheri[D].Jinan:Shandong Normal University,2016.(in Chinese)
[75] 于昕.白藜芦醇对贡氏假鳃鳉寿命、行为和组织学衰老指标的影响[D].济南:山东师范大学,2012. YU X.Effects of resveratrol on longevity,cognitive ability and aging-related histological markers in the annual fish Nothobranchius guentheri[D].Jinan:Shandong Normal University,2012.(in Chinese)
[76] DAI H,DENG H B,WANG Y H,et al.Resveratrol inhibits the growth of gastric cancer via the Wnt/β-catenin pathway[J]. Oncology Letters,2018,16(2):1579-1583.
[77] YAN F Q,SUN X M,XU C H.Protective effects of resveratrol improve cardiovascular function in rats with diabetes[J].Experimental and Therapeutic Medicine,2018,15(2):1728-1734.
[78] ADAM R,LASZLO D,BALAZS S,et al.Cardioprotective effect of resveratrol in a postinfarction heart failure model[J].2017,2017:6819281.
[79] ZHAO X H,CUI Q K,FU Q T,et al.Antiviral properties of resveratrol against pseudorabies virus are associated with the inhibition of IκB kinase activation[J].Scientific Reports,2017,7(1):8782.

The Biological Function of Resveratrol and Its Application in Animal Production

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	LI Jianing, JIANG Zhihui, XING Yueteng, MA Shengming. Effects of 1, 8-cineole Supplementation in Diet on the Antioxidant Capacity of Laying Hens and Eggs [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(7): 3016-3030.
[2]	LI Duo, YUAN Xinxin, SHEN Zhehong, RUAN Fei, ZHAO Lulu, WANG Chuankun, ZENG Yaqi, YAO Xinkui, MENG Jun. Effects of Proline Supplementation on Growth Performance, Antioxidant and Immune Index and Cytokine Contents of Serum in Weaned Foals [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(7): 3084-3092.
[3]	HU Bo, XIONG Pan, HU Junru, LU Huijie, ZHOU Jixing, WANG Guoxia. Effects of Dietary Lipid Levels on Growth, Biochemical Parameters of Liver, Digestion, and Antioxidant Capacity in Hybrid Snakehead (Channa argus♂× Channa maculate♀) Larvae [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(7): 3116-3125.
[4]	WANG Ru, WANG Jiahao, OU Jingyu, TANG Wenhui, CHENG Xiao, WANG Qiangjun, CHEN Jiahong, ZHANG Zijun, REN Chunhuan. Effect of Antioxidants on Freezing Effect of Semen in Ruminants [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(7): 3242-3255.
[5]	WANG Haotian, LI Junzhe, MEI Xiaoying, LI Longxian, LI Yingying, ZHANG Mingrui, WU Yi. Effects of Cuscuta chinensis and Arctium lappa Compound Plant Extracts on Urine Physicochemical,Serum Antioxidant and Immune Indexes in Adult Cats [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(6): 2531-2539.
[6]	LIU Jiayi, WU Hua, SHEN Tong, WANG Kailong, WANG Wensheng, CHEN Zixin. Effects of Extract of Lycium ruthenicum Murr on Growth Performance,Slaughter Performance,Antioxidant Function and Meat Quality of Bamei Ternary Pigs [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(6): 2637-2649.
[7]	CHEN Dandan, QI Yatian, LI Junjie. Mechanisms of Apoptosis and Mitigation Strategies in Vitrification Cryopreservation of Oocytes [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(6): 2729-2735.
[8]	CHEN Haiyan, ZHANG Jingzheng, XU Chenxin, LIU Yuanfen, ZHOU Yongmei, HAN Jin. Exploration of the Pharmacodynamic Substances of Anti-inflammatory and Mechanism of Clematidis Radix Decoction Using UPLC-Q-TOF-MS Combined with Network Pharmacology [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(6): 2851-2864.
[9]	ZHU Longlong, CAI Long, LIU Zeqing, SONG Yanchen, WU Qiujue, WANG Jing. Effects of Isorhapontigenin on Alleviating Oxidative Damage of IPEC-J2 Cells [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(6): 2865-2873.
[10]	HAN Xiaozhuo, WANG Yanping, CUI Zhicheng, YU Le, HAO Jiahui, WANG Yingyu, MO Fei, ZHANG Luyao, CUI Cancan, NIU Shengli. Research Progress of NLRP3 Inflammasome in Veterinary Field [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(6): 2925-2934.
[11]	ZHANG Guanfeng, SONG Xianfan, YAN Zhaoming, YANG Xiaojin, ZHENG Mengli, LIU Yating, CHEN Qinghua. Effects of Dietary Superoxide Dismutase Supplementation on Growth Performance, Immune Performance,Antioxidant Capacity and Intestinal Function of Broilers [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(5): 1987-1998.
[12]	YU Miao, LI Yanjiao, ZHAO Yanling, CHAO Zhe, WANG Feng, LI Menghan, JIANG Zhiqiang, ZHANG Ting, XUE Xinyu, REN Zili, SUN Ruiping. Effects of Weaning Stress on Intestinal Morphology, Antioxidant Capacity and Nrf2 Signaling Pathway of Wuzhishan Piglets [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(5): 2045-2055.
[13]	ZHAO Na, WANG Lizhong, ZHU Lianying, CAI Yumei, LI Shuang, LI Chenghui. Effects of Chestnut Bur Aqueous Extracts on Growth Performance,Organ Coefficient,Antioxidant Function and Tissue Structure in Mice [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(5): 2056-2065.
[14]	LUO Tongwang, JIN Yan, SHENG Yifan, WANG Shujie, SONG Houhui, SHAO Chunyan. Research Progress on the Biological Functions of Isoorientin [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(4): 1579-1589.
[15]	WANG Tongyi, CHEN Jing, JIANG Xinyu, ZHANG Yifei, WANG Hairong, HU Bing, YANG Xujin, YUN Xueyan, GAO Aiwu. Effects of Supplementary Complex Plant Additive on Antioxidant Capacity and Gel Properties of Post-slaughter Mutton [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(3): 1045-1056.