中国畜牧兽医 ›› 2026, Vol. 53 ›› Issue (2): 622-630.doi: 10.16431/j.cnki.1671-7236.2026.02.010

• 综述 • 上一篇    下一篇

美洛昔康在犬猫临床应用中的研究进展

胡琦1,2(), 唐兴刚2, 袁明贵2, 八晓敏2, 田雅2, 张晓爱3, 叶倩妮2(), 向蓉2()   

  1. 1.仲恺农业工程学院动物科技学院,广州 510300
    2.广东省农业科学院动物卫生研究所,广东省畜禽疫病防治研究重点实验室,广州 510640
    3.广东省农业科学院农业生物基因研究中心,广州 510640
  • 收稿日期:2025-06-30 出版日期:2026-02-20 发布日期:2026-01-28
  • 通讯作者: 叶倩妮,向蓉 E-mail:1969145088@qq.com;yeqianni@gdaas.cn;23753842@qq.com
  • 作者简介:胡琦,E-mail:1969145088@qq.com
  • 基金资助:
    广东省农业科学院协同创新项目(XTXM202202);广东省重点研发领域项目(2023B0202150001);广东省畜禽疫病防治研究重点实验室项目(2023B1212060040)

Research Progress on the Clinical Application of Meloxicam in Dogs and Cats

HU Qi1,2(), TANG Xinggang2, YUAN Minggui2, BA Xiaomin2, TIAN Ya2, ZHANG Xiaoai3, YE Qianni2(), XIANG Rong2()   

  1. 1.College of Animal Science and Technology,Zhongkai University of Agriculture and Engineering,Guangzhou 510300,China
    2.Guangdong Province Key Laboratory of Livestock Disease Prevention,Institute of Animal Health,Guangdong Academy of Agricultural Sciences,Guangzhou 510640,China
    3.Agro-Biological Gene Research Center,Guangdong Academy of Agricultural Sciences,Guangzhou 510640,China
  • Received:2025-06-30 Online:2026-02-20 Published:2026-01-28
  • Contact: YE Qianni, XIANG Rong E-mail:1969145088@qq.com;yeqianni@gdaas.cn;23753842@qq.com

摘要:

美洛昔康是一种高选择性环氧合酶-2抑制剂,属于临床常用非甾体抗炎药。其通过有效抑制前列腺素合成,进而发挥显著的抗炎镇痛作用;同时,美洛昔康对环氧合酶-1抑制活性较弱,能显著降低胃肠道及肾脏不良反应风险,使其成为犬猫临床治疗中安全、高效的关键抗炎镇痛药。近年来,随着宠物医疗需求的不断增长,美洛昔康的临床应用价值持续提升。笔者概述了美洛昔康的理化性质与作用机制,系统比较了目前临床常用剂型的优缺点,并进一步探讨了口服半固体制剂及微针贴片等新剂型在提升给药便利性和动物依从性上的潜力。重点评析了美洛昔康在犬猫关节疾病、肿瘤辅助治疗、胰腺炎肠道保护及围手术期镇痛等领域应用的研究进展,分析了当前临床应用所面临的挑战及未来研究方向。以期为美洛昔康在宠物犬猫临床治疗中的安全、合理及高效用药提供科学参考,同时为其创新研发与转化研究提供新思路。

关键词: 犬; 猫; 美洛昔康; 非甾体抗炎药; 宠物医疗

Abstract:

Meloxicam is a highly selective cyclooxygenase-2 inhibitor and is a commonly used nonsteroidal anti-inflammatory drug in clinical practice. It exerts significant anti-inflammatory and analgesic effects by effectively inhibiting the synthesis of prostaglandins. Meanwhile, meloxicam has a relatively weak inhibitory activity against cyclooxygenase-1, which can significantly reduce the risk of adverse reactions in the gastrointestinal tract and kidneys. These properties establish meloxicam as a safe and efficacious therapeutic cornerstone for pain and inflammation management in canine and feline practice. In recent years, with the continuous growth of pet healthcare demands, the clinical value of meloxicam continues to rise. The authors summarized the physicochemical properties and mechanism of action of meloxicam, then systematically compared the advantages and disadvantages of the commonly used formulations in clinical practice, and further discussed the potential of novel formulations such as oral semi-solid preparations and microneedle patches in improving administration convenience and animal compliance. Subsequently, a detailed analysis was conducted on the research progress of meloxicam’s application in areas such as joint diseases in dogs and cats, adjuvant treatment for tumors, pancreatic and intestinal protection and perioperative analgesia. Finally, the challenges and future research directions of current clinical application of meloxicam were analyzed. The aim of this review was to provide a scientific reference for the safe, rational, and efficient use of meloxicam in the clinical treatment of pet dogs and cats, while also offering new insights for its innovative development and translational research.

Key words: dogs; cats; meloxicam; nonsteroidal anti-inflammatory drug; pet medical care

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