猪繁殖与呼吸综合征病毒垂直传播及其危害研究进展

doi:10.16431/j.cnki.1671-7236.2015.05.042

Abstract

Abstract: Productive disorder induced by porcine reproductive and respiratory syndrome virus (PRRSV) is characterized by low conception rate, irregular return to estrus and abortion during early gestation sow; Later-term abortion, early farrowing, stillborn, mummies and weak-born piglets are generally happened at second half of gestation.Piglets with congenital infection become more sensitive to secondary infection, and there exists excreted virus which infects the negative animals on every side.PRRSV passes through the placenta mediated by macrophages/monocytes, which cause pathological damage in the maternal-fetal interface, and virus replication in the fetal implantation sites plays a role in the fetal death and sow abortion.PRRSV infection prevention and viremia shortening for sow are conductive to reduce PRRSV vertical transmission.In addition, biosafety measures, reasonable pig flow and strict disinfection are carried out to control horizontal transmission, and vaccine immunization and medicine administration are done to protect susceptible animals.The main purpose of this review is to summarize PRRSV vertical transmission during each stage of gestation and subsequent reproductive failure.

Key words: porcine reproductive and respiratory syndrome virus; vertical transmission; congenital infection; viremia

CLC Number:

S852.65⁺9.6

LI Tao-mei, LAI Zhi, CUI Li. Research Progress on Porcine Reproductive and Respiratory Syndrome Virus Vertical Transmission and its Hazards[J]. China Animal Husbandry & Veterinary Medicine, 2015, 42(5): 1311-1317.

References

[1] Renukaradhya G J, Alekseev K, Jung K, et al.Porcine reproductive and respiratory syndrome virus-induced immunosuppression exacerbates the inflammatory response to porcine respiratory coronavirus in pigs[J].Viral Immunol, 2010, 23(5):457-466.
[2] Savard C, Pinilla V, Provost C, et al.In vitro effect of deoxynivalenol (DON) mycotoxin on porcine reproductive and respiratory syndrome virus replication[J].Food Chem Toxicol, 2014, 65:219-226.
[3] Corzo C A, Mondaca E, Wayne S, et al.Control and elimination of porcine reproductive and respiratory syndrome virus[J].Virus Res, 2010, 154:185-192.
[4] Sterzl J, Rejnek J, Trávnícek J.Impermeability of pig placenta forantibodies[J].Folia Microbiol, 1966, 11:7-10.
[5] Karniychuk U U, Saha D, Geldhof M, et al.Porcine reproductive and respiratory syndrome virus (PRRSV) causes apoptosis during its replication in fetal implantation sites[J].Microb Pathog, 2011, 51:194-202.
[6] Karniychuk U U, Nauwynck H J.Pathogenesis and prevention of placental and transplacental porcine reproductive and respiratory syndrome virus infection[J].Vet Res, 2013, 44:95.
[7] Ladinig A, Wilkinson J, Ashley C, et al.Variation in fetal outcome, viral load and ORF5 sequence mutations in a large scale study of phenotypic responses to late gestation exposure to type 2 porcine reproductive and respiratory syndrome virus[J].PLoS One, 2014, 9(4):e96104.
[8] Feng D, Nagy J A, Pyne K, et al.Neutrophils emigrate from venules by a transendothelial cell pathway in response to FMLP[J].Exp Med, 1998, 187(6):903-915.
[9] Greenwood J, Howes R, Lightman S.The blood-retinal barrier in experimental autoimmune uveoretinitis.Leukocyte interactions and functional damage[J].Lab Invest, 1994, 70:39-52.
[10] Yoon K J, Wu L L, Zimmerman J J, et al.Antibody dependent enhancement (ADE) of porcine reproductive and respiratory syndrome virus (PRRSV) infection in pigs[J].Viral Immunol, 1996, 9:51-63.
[11] Tirado S M, Yoon K J.Antibody-dependent enhancement of virus infection and disease[J].Viral Immunol, 2003, 16:69-86.
[12] Huttenlocher A, Poznansky M C.Reverse leukocyte migration can be attractive or repulsive[J].Trends Cell Biol, 2008, 18(6):298-306.
[13] Karniychuk U U, De Spiegelaere W, Nauwynck H J.Porcine reproductive and respiratory syndrome virus infection is associated with an increased number of Sn-positive and CD8-positive cells in the maternal-fetal interface[J].Virus Res, 2013, 44:285-291.
[14] Karniychuk U U, Van Breedam W, Van Roy N, et al.Demonstration of microchimerism in pregnant sows and effects of congenital PRRSV infection[J].Vet Res, 2012, 43:19-25.
[15] Garlow J E, Ka H, Johnson G A, et al.Analysis of osteopontin at the maternal-placental interface in pigs[J].Biol Reprod, 2002, 66:718-725.
[16] Rashev P, Georgieva R, Rees D.Expression of alpha5beta1 integrin and fibronectin during early pregnancy in pigs[J].Folia Biol (Praha), 2005, 51:121-125.
[17] Rowland R R.The interaction between PRRSV and the late gestation pig fetus[J].Virus Res, 2010, 154:114-122.
[18] Olanratmanee E O, Wangnaitham S, Thanawongnuwech R, et al.Prevalence of porcine reproductive and respiratory syndrome virus (PRRSV) antigen-positive uterine tissues in gilts culled due to reproductive disturbance in Thailand[J].Trop Anim Health Prod, 2011, 43(2):451-458.
[19] Stockhofe-Zurwieden N, Navarro Camarro J A, Grosse-Beilage E, et al.Uterine and placental alterations in pregnant sows associatedwith the porcine epidemic abortion and respiratory syndrome (PEARS)[J].Zentralbl Veterinarmed B, 1993, 40:261-271.
[20] Lager K M, Halbur P G.Gross and microscopic lesions in porcine fetuses infected with porcine reproductive and respiratory syndrome virus[J].Vet Diagn Invest, 1996, 8:275-282.
[21] Prieto C, Sánchez R, Martín-Rillo S, et al.Exposure of gilts in early gestation to porcine reproductive and respiratory syndrome virus[J].Vet Rec, 1996, 138:536-539.
[22] Mateusen B, Van Soom A, Maes D G, et al.Receptor-determined susceptibility of preimplantation embryos to pseudorabies virus and porcine reproductive and respiratory syndrome virus[J].Biol Reprod, 2007, 76:415-423.
[23] Christianson W T, Collins J E, Benfield D A, et al.Experimental reproduction of swine infertility and respiratory syndrome in pregnant sows[J].Am J Vet Res, 1992, 53:485-488.
[24] Kranker S, Nielsen J, Bille-Hansen V, et al.Experimental inoculation of swine at various stages of gestation with a Danish isolate of porcine reproductive and respiratory syndrome virus (PRRSV)[J].Vet Microbiol, 1998, 61:21-31.
[25] Mengeling W L, Lager K M, Vorwald A C.Temporal characterization of transplacental infection of porcine fetuses with porcine reproductive and respiratory syndrome virus[J].Am J Vet Res, 1994, 55:1391-1398.
[26] Prieto C, García C, Simarro I, et al.Temporal localization of porcine reproductive and respiratory syndrome virus in reproductive tissues of experimentally infected boars[J].Theriogenology, 2003, 60(8):1505-1514.
[27] Sur J H, Doster A R, Christian J S, et al.Porcine reproductive and respiratory syndrome virus replicates in testicular germ cells, alters spermatogenesis and induces germ cell death by apoptosis[J].J Virol, 1997, 71(12):9170-9179.
[28] Christopher-Hennings J, Nelson E A, Nelson J K, et al.Identification of porcine reproductive and respiratory syndrome virus in semen and tissues from vasectomized and nonvasectomized boars[J].Vet Pathol, 1998, 35(4):260-267.
[29] Christopher-Hennings J, Nelson E A, Hines R J, et al.Persistence of porcine reproductive and respiratory syndrome virus in serum and semen of adult boars[J].Vet Diagn Invest, 1995, 7(4):456-464.
[30] Christopher-Hennings J, Holler L D, Benfield D A, et al.Detection and duration of porcine reproductive and respiratory syndrome virus in semen, serum, peripheral blood mononuclear cells, and tissues from Yorkshire, Hampshire, and Landrace boars[J].Vet Diagn Invest, 2001, 13:133-142.
[31] Bøtner A, Strandbygaard B, Sorensen K J, et al.Appearance of acute PRRS-like symptoms in sow herds after vaccination with a modified live PRRS vaccine[J].Vet Rec, 1997, 141:497-499.
[32] Park B K, Yoon I J, Joo H S.Pathogenesis of plaque variants of porcine reproductive and respiratory syndrome virus in pregnant sows[J].Am J Vet Res, 1996, 57:320-323.
[33] Karniychuk U U, Geldhof M, Vanhee M, et al.Pathogenesis and antigenic characterization of a new East European subtype 3 porcine reproductive and respiratory syndrome virus isolate[J].BMC Vet Res, 2010, 6:30-39.
[34] 黄勤锋.猪繁殖与呼吸综合征病毒的感染性克隆及其复制子载体的研究[D].武汉:华中农业大学, 2009.
[35] Cheon D S, Chae C.Distribution of porcine reproductive and respiratory syndrome virus in stillborn and liveborn piglets from experimentally infected sows[J].J Comp Pathol, 2001, 124:231-237.
[36] Lunney J K, Benfield D A, Rowland R R.Porcine reproductive and respiratory syndrome virus:An update on an emerging and re-emerging viral disease of swine[J].Virus Res, 2010, 154:1-6.
[37] Prieto C, Castro J M.Porcine reproductive and respiratory syndrome virus infection in the boar:A review[J].Theriogenology, 2005, 63:1-16.
[38] 姚敬明, 孟帆, 吴忻, 等.猪繁殖与呼吸综合征母源抗体和免疫抗体的消长规律研究[J].中国畜牧兽医, 2010, 37(4):205-208.
[39] Kang I, Ha Y, Kim D, et al.Localization of porcine reproductive and respiratory syndrome virus in mammary glands of experimentally infected sows[J].Res Vet Sci, 2010, 88(2):304-310.
[40] Rowland R R, Lawson S, Rossow K, et al.Lymphoid tissue tropism of porcine reproductive and respiratory syndrome virus replication during persistent infection of pigs originally exposed to virus in utero[J].Vet Microbiology, 2003, 96(3):219-235.
[41] Done S H, Paton D J.Porcine reproductive and respiratory syndrome:Clinical disease, pathology and immunosuppression[J].Vet Rec, 1995, 136:32-35.
[42] Wills R W, Doster A R, Galeota J A, et al.Duration of infection and proportion of pigs persistently infected with porcine reproductive and respiratory syndrome virus[J].Clin Microbiol, 2003, 41:58-62.
[43] Riber U, Nielsen J, Lind P.In utero infection with PRRS virus modulates cellular functions of blood monocytes and alveolar lung macrophages in piglets[J].Vet Immunol Immunopathol, 2004, 99(3-4):169-177.
[44] Feng W, Laster S M, Tompkins M, et al.In utero infection by porcine reproductive and respiratory syndrome virus is sufficient to increase susceptibility of piglets to challenge by Streptococcus suis typeⅡ[J].Journal of Virology, 2001, 75(10):4889-4895.
[45] Brockmeier S L, Palmer M V, Bolin S R, et al.Effects of intranasal inoculation with Bordetella bronchiseptica, porcine reproductive and respiratory syndrome virus, or a combination of both organisms on subsequent infection with Pasteurella multocida in pigs[J].Am J Vet Res, 2001, 62(4):521-526.
[46] Sinha A, Shen H G, Schalk S, et al.Porcine reproductive and respiratory syndrome virus (PRRSV) influences infection dynamics of porcine circovirus type 2 (PCV2) subtypes PCV2a and PCV2b by prolonging PCV2 viremia and shedding[J].Vet Microbiol, 2011, 152(3-4):235-246.
[47] Prieto C, Suárez P, Simarro I, et al.Transplacental infection following exposure of gilts to porcine reproductive and respiratory syndrome virus at the onset of gestation[J].Vet Microbiol, 1997, 57:301-311.
[48] Sun X Z, Wertz N, Lager K L, et al.Antibody repertoire development in fetal and neonatal piglets.ⅩⅩⅢ:Fetal piglets infected with a vaccine strain of PRRS virus display the same immune dysregulation seen in isolator piglets[J].Vaccine, 2012, 30(24):3646-3652.
[49] Stuart A D, Brown T D K, Mockett A P A.Tywalosin, a macrolide antibiotic, inhibits the in-vitro replication of European and American porcine reproductive and respiratory syndrome virus (PRRS) viruses[J].The Pig Journal, 2008, 61:42-48.

Research Progress on Porcine Reproductive and Respiratory Syndrome Virus Vertical Transmission and its Hazards

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	LI Songbei, XIE Yongsheng, LONG Xiaoqin, ZHANG Xiaoxiao, CHEN Yongjie, ZHANG Chunhong, JIAO Maoxing, GUO Chunhe. Genetic Variation Analysis of Porcine Reproductive and Respiratory Syndrome Virus in South China in 2023 [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(1): 331-340.
[2]	YU Jingxue, WEI Shanshan, QIN Shaomin, WU Jianmin, YANG Lihua, CHEN Fenglian, XU Lishi, QIN Shuying, HUA Jun, WEI Jue, FANG Fang, LIU Jinfeng. Establishment of a Rapid Detection Method for Porcine Reproductive and Respiratory Syndrome Virus Based on CRISPR/Cas12a-RT-RAA [J]. China Animal Husbandry & Veterinary Medicine, 2024, 51(8): 3237-3246.
[3]	QIAO Changhong, CHEN Jing, LUO Qin, LIU Baoling, HE Zhenwen, LIU Dingyu, CHEN Xiangyu, WANG Xiaohu, WANG Gang, BAI Aiquan, CAI Rujian. Advances in Inflammation Induced by Porcine Reproductive and Respiratory Syndrome Virus and Anti-inflammatory Drugs [J]. China Animal Husbandry & Veterinary Medicine, 2024, 51(8): 3528-3539.
[4]	DONG Zexia, LIN Xin, ZHOU Qilyu, WANG Nan, HUANG Lei, LIU Zhiguo, FENG Zheng, MU Yulian. Construction and PRRSV Infection Characteristic Analysis of CD163 Gene Knockout iPAMs [J]. China Animal Husbandry & Veterinary Medicine, 2024, 51(8): 3471-3483.
[5]	XIAN Yuhan, FENG Hongsheng, GAO Yongyu, LI Haiyang, YANG Siyu, SANG Chenjun, CAO Yudie, TANG Yue, LI Zibin, GAO Fengshan. Advances in Cytotoxic T Lymphocyte Epitopes of Porcine Viruses [J]. China Animal Husbandry & Veterinary Medicine, 2024, 51(7): 3086-3099.
[6]	LUO Qin, LIU Baoling, QIAO Changhong, CHEN Xiangyu, LIU Dingyu, WANG Xiaohu, WANG Gang, LIU Hao, CAI Rujian. Research Progress on the Role of Lipid Metabolism and Glucose Metabolism in PRRSV-infected Host Cells [J]. China Animal Husbandry & Veterinary Medicine, 2024, 51(4): 1686-1695.
[7]	WANG Hui, FENG Baoliang, XIANG Guangming, HUANG Lei, LIU Zhiguo, LI Kui, MU Yulian. Construction of iPAMs with CD163 Monoallelic Expression and Characterization of Their Mediating PRRSV Infection [J]. China Animal Husbandry & Veterinary Medicine, 2023, 50(7): 2617-2628.
[8]	KANG Pu, REN Zhaowen, CAI Rujian, LYU Zongji, HUANG Yuhao, WANG Xiaohu. Variation Regularity and Transmission of PRRSV-2 Lineage 8 Strains in Guangdong and Surrounding Provinces [J]. China Animal Husbandry & Veterinary Medicine, 2023, 50(5): 2001-2011.
[9]	CHEN Tianbao, WANG Yani, LIU Baoling, WANG Gang, WANG Xiaohu, LIU Xuhui, CAI Rujian, HE Dongsheng. Research Progress on the Anti-Porcine Reproductive and Respiratory Syndrome Virus Effect and Mechanism of Traditional Chinese Medicine [J]. China Animal Husbandry & Veterinary Medicine, 2023, 50(5): 2114-2129.
[10]	LI Huawei, GUO Kewei, WANG Xuying, ZHANG Xiaoyu, LU Ziwei, LI Xinfeng, MA Hui, HOU Wenjing. Eukaryotic Expression and Subcellular Localization of Nonstructural Protein 7 of Porcine Reproductive and Respiratory Syndrome Virus [J]. China Animal Husbandry & Veterinary Medicine, 2023, 50(3): 1160-1168.
[11]	YAN Pupu, LIU Xin, LIN Bing, LIU Jiali, XIA Jinjin, HUANG Yongxi, BAI Ruonan, LIU Guoping, YANG Xiaolin, GUO Liwei. Exploring of the Infection Characteristics of Porcine Reproductive and Respiratory Syndrome Virus and the Prevention and Control Mechanism of Yinhua Gancao Decoction Based on Bioinformatics [J]. China Animal Husbandry & Veterinary Medicine, 2023, 50(10): 4196-4209.
[12]	LIU Qingqing, WU Peng, LI Peidong, ZHANG Jiangwei, CHEN Chuangfu, XIAO Chencheng. Construction of Recombinant Adenovirus Expressing Porcine Reproductive and Respiratory Syndrome Virus N Protein and Its Immunogenicity Analysis [J]. China Animal Husbandry & Veterinary Medicine, 2022, 49(3): 1024-1031.
[13]	WANG Zhaoli, YANG Siyu, WU Yanmei, SONG Xiaoxiao, MU Xiang, ZHANG Tao. Effects of PRRSV-LPS Treatment on Neutrophil Adhesion to Porcine Pulmonary Microvascular Endothelial Cells [J]. China Animal Husbandry & Veterinary Medicine, 2022, 49(2): 471-479.
[14]	SUN Lu, ZHANG Jing, YIN Miao, CHENG Yaodie, DAI Kun, WU Qian, ZHAO Hong, CHEN Xiwen. Study on the Antibacterial and Anti-PRRSV Activities of Four Heat Clearing and Detoxifying Compound Chinese Herbal Medicine in vitro [J]. China Animal Husbandry & Veterinary Medicine, 2022, 49(2): 746-754.
[15]	CHU Pinpin, JIANG Zhiyong, LI Chunling, GOU Hongchao, LI Yan, CAI Rujian. Antiviral Effect of Silver Nanoparticles on Porcine Reproductive and Respiratory Syndrome Virus in vitro [J]. China Animal Husbandry & Veterinary Medicine, 2022, 49(11): 4356-4363.