长链非编码RNA调控牛科反刍动物相关经济性状的研究进展

doi:10.16431/j.cnki.1671-7236.2024.01.021

Abstract

Abstract: Long non-coding RNA (lncRNA) is a eukaryotic transcript that is longer than 200 nucleotides and does not have the ability to code itself.It regulates the expression of genes mainly through transcriptional level, post-transcriptional level and epigenetics, and is ubiquitous in animal and plant genomes.lncRNA is a regulatory molecule that plays a key role in the growth and development, cell differentiation and disease occurrence of animals and plants.Compared with research in the medical field, the study of lncRNA in bovine ruminants is still in its infancy, especially in the regulation of economic traits related to bovine ruminants.In recent years, the rapid development of high-throughput sequencing and microarray technology has provided more efficient and rapid methods for the identification of lncRNA.Therefore, the author reviews the research findings, feature classification, post-transcriptional horizontal regulation mechanism of lncRNA and their research on muscle growth, hair follicle development and lactation traits in bovine ruminants, which lays a theoretical foundation for further research on the regulatory mechanism of lncRNA in the growth and development of bovine ruminants.

Key words: lncRNA; bovidne ruminants; growth and development; economic traits

CLC Number:

S813.3

CHEN Yu, LIU Junyang, MU Qing, LU Zeyu, LI Yunhua, LIU Jiasen, WU Zixian, WANG Haoyuan, SUN Yiwen, ZHAO Yanhong. Research Progress on the Regulation of Economic Traits Related to Bovine Ruminants by Long-chain Non-coding RNA[J]. China Animal Husbandry & Veterinary Medicine, 2024, 51(1): 203-211.

References

[1] GE D, HAN L, HUANG S, et al.Identification of a novel MTOR activator and discovery of a competing endogenous RNA regulating autophagy in vascular endothelial cells autophagy[J].RNA Biology, 2014, 11(7):957-971.
[2] QIN C Y, CAI H, QING H R, et al.Recent advances on the role of long non-coding RNA H19 in regulating mammalian muscle growth and development[J].Hereditas, 2017, 39(12):1150-1157.
[3] BROWN C J, BALLABIO A, RUPERT J L, et al.A gene from the region of the human X inactivation centre is expressed exclusively from the inactive X chromosome[J].Nature, 1991, 349(6304):38-44.
[4] 陶维昆, 刘波, 黄飞, 等.Xist lncRNA介导X染色体失活及应用研究进展[J].中国畜牧兽医, 2022, 49(1):216-223. TAO W K, LIU B, HUANG F, et al.Research progress on Xist lncRNA mediated X chromosome inactivation and its application[J].China Animal Husbandry & Veterinary Medicine, 2022, 49(1):216-223.(in Chinese)
[5] RINN J, KERTESZ M, WANG J, et al.Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs[J].Cell, 2007, 129(7):1311-1123.
[6] 贾纯琰.受外源褪黑素诱导的绒山羊皮肤中调控绒生长的mRNA和lncRNA的研究[D].呼和浩特:内蒙古农业大学, 2022. JIA C Y.mRNA and lncRNA induced by exogenous melatonin that regulate cashmere growth in cashmere goat skin[D].Hohhot:Inner Mongolia Agricultural University, 2022.(in Chinese)
[7] 白海静.基于生物网络的大鼠肝再生相关lncRNA的调控网络分析[D].新乡:河南师范大学, 2020. BAI H J.Regulatory network analysis of rat liver regeneration related lncRNA based on biological network[D].Xinxiang:Henan Normal University, 2020.(in Chinese)
[8] 黄斌.基于多相似性网络融合的lncRNA与疾病关联预测研究[D].广州:广东工业大学, 2021. HUANG B.Research on prediction of lncRNA-disease association based on multi-similarity network fusion[D].Guangzhou:Guangdong University of Technology, 2021.(in Chinese)
[9] DINGER M, AMARAL P, MERCER T, et al.Long noncoding RNAs in mouse embryonic stem cell pluripotency and differentiation[J].Genome Research, 2008, 18(9):1433-1445.
[10] BHAT S, AHMAD S, MUMTAZ P, et al.Long non-coding RNAs:Mechanism of action and functional utility[J].Non-coding RNA Research, 2016, 1(1):43-50.
[11] 常永芳, 包鹏甲, 褚敏, 等.lncRNA在哺乳动物毛囊发育调控中的研究进展[J].生物技术通报, 2019, 35(8):205-212. CHANG Y F, BAO P J, CHU M, et al.Research progress on the regulation of lncRNA in the development of mammalian hair follicle[J].Biotechnology Bulletin, 2019, 35(8):205-212.(in Chinese)
[12] NOORUL A, ANNETTE M, YI P.Evaluation of deep learning in non-coding RNA classification[J].Nature Machine Intelligence, 2019, 1(5):25-27.
[13] LING S, XU T, SUN J, et al.Expression of lncRNA MALAT1 through miR-144-3p in osteoporotic tibial fracture rats and its effect on osteogenic differentiation of BMSC under traction[J].Evidence-based Complementary and Alternative Medicine, 2022, 6(5):59-65.
[14] PASQUE V, TCHIEU J, KARNIK R, et al.X chromosome reactivation dynamics reveal stages of reprogramming to pluripotency[J]. Cell, 2014, 9(7):1681-1697.
[15] AGRAWAL N, DASARADHI P, MOHMMED A, et al.RNA interference:Biology, mechanism, and applications[J].Microbiology and Molecular Biology Reviews, 2003, 7(4):657-785.
[16] ZHU Y, ZHOU B, HU X, et al.lncRNA LINC00942 promotes chemoresistance in gastric cancer by suppressing MSI2 degradation to enhance c-Myc mRNA stability[J].Clinical and Translational Medicine, 2022, 12(1):e703.
[17] QURESHI I, MEHLER M.Non-coding RNA networks underlying cognitive disorders across the lifespan[J].Trends in Molecular Medicine, 2011, 7(6):337-346.
[18] LI Q, SUN H, LUO D, et al.lnc-RP11-536 K7.3/SOX2/HIF-1α signaling axis regulates oxaliplatin resistance in patient-derived colorectal cancer organoids[J].Journal of Experimental & Clinical Cancer Research, 2021, 5(1):341-348.
[19] ZHANG X, YIN Q, WANG H, et al.Species-specific alternative splicing leads to unique expression of sno-lncRNAs[J]. BMC Genomics, 2014, 15:287.
[20] GENTILIN E, GANDEL L, PAO L.Coding the noncoding:2 years of advances in the field of microRNAs and long noncoding RNAs[J].Cancer Gene Therapy, 2021, 28(5):71-88.
[21] RIKI K K.Long Noncoding RNAs[M].Tokyo:Springer, 2016.
[22] STATELLO L, GUO C, CHEN L, et al.Gene regulation by long non-coding RNAs and its biological functions[J]. Nature Reviews Molecular Cell Biology, 2021, 22(2):96-118.
[23] SHUMAN S.Transcriptional interference at tandem lncRNA and protein-coding genes:An emerging theme in regulation of cellular nutrient homeostasis[J].Nucleic Acids Research, 2020, 4(15):8243-8254.
[24] 陈施彤, 王以婷, 常琦, 等.lncRNA HNF4α-AS1参与调控转录因子和细胞色素CYP450表达[J].中国药理学与毒理学杂志, 2019, 33(10):810-819. CHEN S T, WANG Y T, CHANG Q, et al.lncRNA HNF4α-AS1 involved in regulating transcription factor and cytochrome CYP450 expression[J].Chinese Journal of Pharmacology and Toxicology, 2019, 33(10):819.(in Chinese)
[25] 王喜周, 李凌云, 周武.乳腺癌中长链非编码RNA H19可变剪接体的鉴定[J].丽水学院学报, 2021, 43(5):62-65. WANG X Z, LI L Y, ZHOU W.Identification of H19 lncRNA alternative splicing variants in breast cancer[J].Journal of Lishui University, 2021, 43(5):62-65.(in Chinese)
[26] QIU J, MA X, ZENG F, et al.RNA editing regulates lncRNA splicing in human early embryo development[J].PLoS Computational Biology, 2021, 17(12):e1009630.
[27] ZHAO R, LI J, LIU N, et al.Transcriptomic analysis reveals the involvement of lncRNA-miRNA-mRNA networks in hair follicle induction in Aohan Fine wool sheep skin[J].Frontiers in Genetics, 2020, 9(11):590.
[28] 孙丽.lncRNA-FUT3AS介导组蛋白H4修饰调控断奶仔猪F18大肠杆菌抗性的分子机制研究[D].扬州:扬州大学, 2020. SUN L.Molecular mechanism of lncRNA-FUT3AS mediated histone H4 modification regulating F18 E.coli resistance in weaned piglets[D].Yangzhou:Yangzhou University, 2020.(in Chinese)
[29] TSAI M C, MANOR O, WAN Y, et al.Long noncoding RNA as modular scaffold of histone modification complexes[J].Science, 2010, 329(5992):689-693.
[30] HE Y, DAN Y, GAO X, et al.DNMT1-mediated lncRNA MEG3 methylation accelerates endothelial-mesenchymal transition in diabetic retinopathy through the PI3K/Akt/mTOR signaling pathway[J].American Journal of Physiology-endocrinology and Metabolism, 2021, 320(3):E598-E608.
[31] HESKETT M, SMITH L, SPELLMAN P, et al.Reciprocal monoallelic expression of ASAR lncRNA genes controls replication timing of human chromosome 6[J]. RNA, 2020, 26(6):724-738.
[32] 郭宏.牛肌肉发育分化过程中关键lncRNA功能及其调控机制研究[D].天津:天津农学院, 2020. GUO H.Key lncRNA functions and their regulatory mechanisms during bovine muscle development differentiation[D].Tianjin:Tianjin Agricultural College, 2020.(in Chinese)
[33] 岳英伟.牛肌肉高表达lncRNA的筛选及功能研究[D].天津:天津农学院, 2017. YUE Y W.Screening and functional study of high expression lncRNA in bovine muscle[D].Tianjin:Tianjin Agricultural University, 2017.(in Chinese)
[34] YUE Y, JIN C, CHEN M, et al.A lncRNA promotes myoblast proliferation by up-regulating GH1[J].In Vitro Cellular & Developmental Biology Animal, 2017, 53(8):699-705.
[35] 牛慧慧.lncYYW互作miRNA调控牛骨骼肌卫星细胞分化机制的研究[D].天津:天津农学院, 2020. NIU H H.Study on the mechanism of lncYYW interaction miRNA regulating the differentiation of bovine skeletal muscle satellite cells[D].Tianjin:Tianjin Agricultural University, 2020.(in Chinese)
[36] SONG C, YANG Z, JIANG R, et al.lncRNA IGF2 as regulates bovine myogenesis through different pathways[J]. Molecular Therapy-Nucleic Acids, 2020, 21:874-884.
[37] LI H, YANG J, JIANG R, et al.Long non-coding RNA profiling reveals an abundant MDNCR that promotes differentiation of myoblasts by sponging miR-133a[J].Molecular Therapy-Nucleic Acids, 2018, 12:610-625.
[38] 王利宏.lncRNA-TCONS_00153891-miRNA-29a-YAP1调控湖羊肌肉细胞增殖的分子机制研究[D].扬州:扬州大学, 2019. WANG L H.The molecular mechanism of lncRNA-TCONS_00153891-miRNA-29a-YAP1 regulating the proliferation and of muscle cells in Hu sheep[D].Yangzhou:Yangzhou University, 2019.(in Chinese)
[39] WU T, WANG S, WANG L, et al.Long noncoding RNA (lncRNA) CTTN-IT1 elevates skeletal muscle satellite cell proliferation and differentiation by acting as ceRNA for YAP1 through absorbing miR-29a in Hu sheep[J]. Frontiers in Genetics, 2020, 7(11):843.
[40] WEI C, WU M, WANG C, et al.Long noncoding RNA lnc-SEMT modulates IGF2 expression by sponging miR-125b to promote sheep muscle development and growth[J].Cellular Physiology and Biochemistry, 2018, 49(2):447-462.
[41] CHAO T, JI Z, HOU L, et al.Sheep skeletal muscle transcriptome analysis reveals muscle growth regulatory lncRNAs[J]. PeerJ, 2018, 6:e4619.
[42] FAN Y, REN C, DENG K, et al.The regulation of lncRNA GTL2 expression by DNA methylation during sheep skeletal muscle development[J].Genomics, 2022, 114(5):110453.
[43] 黄超男.大足黑山羊肌肉发育相关lncRNA的筛选与鉴定[D].重庆:西南大学, 2022. HUANG C N.Screening and identification of lncRNA related to muscle development in Dazu Black goats[D].Chongqing:Southwest University, 2022.(in Chinese)
[44] ZHANG X, BAO P, YE N, et al.Identification of the key genes associated with the yak hair follicle cycle[J]. Genes (Basel), 2021, 13(1):32-34.
[45] ZHANG X, BAO Q, JIA C, et al.Genome-wide detection and sequence conservation analysis of long non-coding RNA during hair follicle cycle of yak[J].BMC Genomics, 2020, 21(1):681.
[46] 倪萍.辽宁绒山羊绒相关lncRNA XLOC_005914的鉴定及对其靶基因表达的影响[D].大连:辽宁师范大学, 2020. NI P.Identification of cashmere-related lncRNA XLOC_005914 in Liaoning cashmere goats and its effect on target gene expression[D].Dalian:Liaoning Normal University, 2020.(in Chinese)
[47] JIAO Q, WANG Y R, ZHAO J Y, et al.Identification and molecular analysis of cashmere goat lncRNAs reveal their integrated regulatory network and potential roles in secondary hair follicle[J].Animal Biotechnology, 2021, 32(6):719-732.
[48] BAI W L, ZHAO S J, WANG Z Y, et al.lncRNAs in secondary hair follicle of cashmere goat:Identification, expression, and their regulatory network in Wnt signaling pathway[J].Animal Biotechnology, 2018, 29(3):199-211.
[49] WANG S N, GE W, LUO Z X, et al.Integrated analysis of coding genes and non-coding RNAs during hair follicle cycle of cashmere goat (Capra hircus)[J].BMC Genomics, 2017, 18(1):767-789.
[50] 焦倩.辽宁绒山羊次级毛囊lncRNAs鉴别、表达特征及功能调控网络研究[D].沈阳:沈阳农业大学, 2020. JIAO Q.Identification, expression characteristics and functional regulation network of lncRNAs of secondary hair follicles in Liaoning cashmere goats[D].Shenyang:Shenyang Agricultural University, 2020.(in Chinese)
[51] 孙昊然, 孟科, 李新海.杜泊羊毛囊发育lncRNA转录组以及lncRNA-MSTRG.13836.1功能的生物信息学分析[J].中国草食动物科学, 2023, 43(3):1-8. SUN H R, MENG K, LI X H.The lncRNA transcriptome of Dorper sheep hair follicle development and bioinformatics analysis of lncRNA-MSTRG.13836.1 function[J].Chinese Herbivore Science, 2023, 43(3):1-8.(in Chinese)
[52] 王学辉.lncRNA和miRNA在奶牛乳品质调控中的作用[D].哈尔滨:东北农业大学, 2017. WANG X H.The role of lncRNA and miRNA in the quality regulation of dairy milk[D].Harbin:Northeast Agricultural University, 2017.(in Chinese)
[53] XUE Z L, HAO W, YAN F Z, et al.Overexpression of lncRNA H19 changes basic characteristics and affects immune response of bovine mammary epithelial cells[J].PeerJ, 2019, 7:e6715.
[54] YANG B, JIAO B L, GE W, et al.Transcriptome sequencing to detect the potential role of long non-coding RNAs in bovine mammary gland during the dry and lactation period[J].BMC Genomics, 2018, 19(1):605.
[55] ZENG B, CHEN T, XIE M Y, et al.Exploration of long noncoding RNA in bovine milk exosomes and their stability during digestion in vitro[J].Journal of Dairy Science, 2019, 102(8):6726-6737.
[56] CHEN W, LV X, WANG Y, et al.Transcriptional profiles of long non-coding RNA and mRNA in sheep mammary gland during lactation period[J]. Front Genet, 2020, 11:946.
[57] HAO Z, LUO Y, WANG J, et al.RNA-Seq reveals the expression profiles of long non-coding RNAs in lactating mammary gland from two sheep breeds with divergent milk phenotype[J]. Animals (Basel), 2020, 10(9):1565.
[58] 王继卿, 郝志云, 沈继源, 等.小尾寒羊泌乳性状重要lncRNAs的筛选、鉴定及功能分析[J].中国农业科学, 2021, 54(14):3113-3123. WANG J Q, HAO Z Y, SHEN J Y, et al.Screening, identification and functional analysis of important lncRNAs for lactation traits in Small-tailed Han sheep[J].Scientia Agricultura Sinica, 2021, 54(14):3113-3123.(in Chinese)
[59] 郝志云.绵羊泌乳性状非编码RNA筛选、鉴定及功能研究[D].兰州:甘肃农业大学, 2021. HAO Z Y.Screening, identification and functions study of non-coding RNAs for ovine lactation traits[D].Lanzhou:Gansu Agricultural University, 2021.(in Chinese)
[60] 胡凯召.奶山羊注射5-HTP的全转录组测序分析及ATF3基因在乳腺上皮细胞中的功能验证[D].杨凌:西北农林科技大学, 2020. HU K Z.Whole transcriptome sequencing analysis of dairy goats injected with 5-HTP and function verification of ATF3 gene in goat mammary epithelial cells[D].Yangling:Northwest A&F University, 2020.(in Chinese)

Research Progress on the Regulation of Economic Traits Related to Bovine Ruminants by Long-chain Non-coding RNA

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	JIA Chunyan, SUN Yanyong, BAO Yonghong, ZHANG Wenguang, DU Chenguang. Alternative Splicing Analysis of mRNA and lncRNA Induced by Exogenous Melatonin for Regulating Cashmere Growth Based on Transcriptomics [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(7): 3165-3177.
[2]	NIU Shuran, PAN Jianfeng, RONG Youjun, AO Xiaofang, WANG Yihan, SHANG Fangzheng, WANG Ruijun, ZHANG Yanjun. Advances on the Application of Circular RNA in Important Economic Traits in Sheep [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(6): 2468-2481.
[3]	REN Hao, ZHU Yixuan, CHAO Tingting, WANG Xiaoyi, LU Shaoxiong, YANG Yongli, CHEN Qiang, LI Mingli. Identification and Functional Prediction of lncRNA in Longissimus Dorsi Muscle of Saba Pigs with Different Growth Rates [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(6): 2494-2505.
[4]	WU Min, XU Junjie, LI Xinxin, CHEN Yifan, WANG Dehe, HAO Erying, CHEN Hui, SHI Lei. Screening of Key Genes Regulating Muscle Development in Yellow-feathered Chickens Based on RNA-Seq [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(3): 990-1000.
[5]	LI Jingxuan, LIN Yanjiao, HUANG Qiongjun, HAN Xinyan, ZHANG Yuelang. Research Progress on Non-coding RNA Related to Skeletal Muscle Development in Goats [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(2): 582-592.
[6]	WANG Yong, MA Chi, WANG Chao, ZHAO Qinan, SUN Zhipeng, TIAN Feng, WANG Li, JIN Hai, LI Changqing. Research Progress on Molecular Mechanism of miRNA and lncRNA Regulating Follicular Development in Ruminants [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(2): 771-780.
[7]	YANG Li, DU Xiaomei, LIU Mengyuan, WU Shenglong, BAO Wenbin, WU Zhengchang. Screening and Functional Verification of Key lncRNA Affecting Porcine Epidemic Diarrhea Virus Replication [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(2): 792-800.
[8]	WANG Qiushi, LI Jiangling, ZHAO Sujun, LIU Rui. Identification and Function Prediction of lncRNA Related to Reproductive Function of Uterine Body in Tibetan and Chuanxiang Black Pigs During Pregnancy [J]. China Animal Husbandry & Veterinary Medicine, 2024, 51(8): 3417-3427.
[9]	ZHANG Ke, ZHANG Min, LI Tianbao, ZHANG Jie, LU Shengsheng, JIANG Mingsheng. Screening of Differential lncRNAs and Construction of ceRNA Network in Ovary Tissue of Guangxi Ma Chicken [J]. China Animal Husbandry & Veterinary Medicine, 2024, 51(7): 2739-2750.
[10]	WANG Meijie, LIU Xingwang, BAI Man. Research Progress on the Role of lncRNA in Mammalian Male Reproduction [J]. China Animal Husbandry & Veterinary Medicine, 2024, 51(7): 2963-2972.
[11]	WANG Suwan, FENG Xiaofang, TONG Lijia, LI Desheng, WANG Yu, FENG Yuan, JIANG Qiufei, XU Jun, CHEN Yafei, GU Yaling, ZHANG Juan. Genetic Parameter Estimation of Growth and Developmental Traits in Angus Cattle During Weaning Stage [J]. China Animal Husbandry & Veterinary Medicine, 2024, 51(6): 2517-2523.
[12]	ZHANG Chi, LIU Chao, WANG Yiman, MIAO Dongzhi, CHEN Jing, WANG Ying, YANG Haiming, WANG Zhiyue. Functional Analysis of lncRNA and mRNA in the Pectoralis Muscle of White King Pigeons at Different Days of Age [J]. China Animal Husbandry & Veterinary Medicine, 2024, 51(5): 1827-1836.
[13]	CHEN Bohe, LIUFU Sui, YU Zonggang, WANG Kaiming, LIU Xiaolin, YI Lei, MA Haiming. Research Progress on the Regulation of Non-coding RNA in Muscle Fiber-type Conversion in Animals [J]. China Animal Husbandry & Veterinary Medicine, 2024, 51(3): 1132-1141.
[14]	YANG Yuming, ZHAO Xinming, TAN Baohua, XIAO Liyao, LU Geyan, ZHAI Lijun, HUANG Yiyang, HONG Linjun, GU Ting. Effect of Long Non-coding RNA MSTRG.14200 on Porcine Skeletal Muscle Satellite Cell Differentiation and Muscle Fiber Transformation [J]. China Animal Husbandry & Veterinary Medicine, 2024, 51(2): 453-461.
[15]	LIU Ling, WANG Shengnan, WANG Dandan, MA Yuehui, JIANG Lin, CUI Kai. Effect and Molecular Mechanism of Zbed6 Gene Knockout on the Growth and Development of Skeletal Muscle in Mice [J]. China Animal Husbandry & Veterinary Medicine, 2023, 50(9): 3641-3651.