猪脾脏结构和功能及其免疫关键基因研究进展

doi:10.16431/j.cnki.1671-7236.2020.06.009

Abstract

Abstract: The spleen,as the largest secondary lymphoid organ in pigs,contains a variety of immune-active cells and immune factors.It is an important organ of response and regulation for innate and adaptive immunity,and has extensive immune regulatory functions.At the same time,it can remove old aged and damaged red blood cells,filter out pathogens,play an important role in hematopoiesis and blood cells storage.These functions are closely related to the structure of the spleen.Among them,the red pulp is mainly used as a blood filter to perform the functions of hematopoiesis,blood storage and foreign objects removal.The white pulp is the main area ofimmunization,containing varieties of immune cells,which can perform the functions of specific immunity and response regulatory.The marginal zone is a key bridge which connects the red and white pulps,allowing all immune cells and antigens to enter different parts of spleen.Different key genes are fundamental for development and immunity to the realization of spleen function.The expression of developmental related genes guarantees the structural integrity and provides chance for the spleen to perform various functions.The expression of key immune genes ensures the immune response,in which the expression of different pattern recognition receptor genes ensures the phagocytosis and recognition response of innate immunity,and a variety of cytokines and immunoactive substances secreted by various immune cells are acquired.The basis of the immune response is the physiological process of antigens clearance and monitoring.With the development of spleen research,a new understanding of its various immune cells and immune functions has been gained.This article firstly explained the biological functions of different components of spleen,then discussed their functions of innate and specific immune,and the role and connection of the vital immune cells and immune factors.In the end,the development of spleen tissues and immune related genes which in embryonic and postnatal period were introduced,and the important pattern recognition receptors and their gene family in innate immunity of spleen in pig were summarized,which can provide reference for the study of innate immune function of spleen in pig.

Key words: spleen; tissue structure; immune function; innate immune; regulatory genes

CLC Number:

R392.1

SONG Yukun, HE Jun. Research Progress on Structure,Function and Its Key Immune Genes of Spleen in Pigs[J]. China Animal Husbandry & Veterinary Medicine, 2020, 47(6): 1709-1718.

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Research Progress on Structure,Function and Its Key Immune Genes of Spleen in Pigs

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