外泌体长链非编码RNA对脂代谢调控机制的研究进展

doi:10.16431/j.cnki.1671-7236.2020.04.007

Abstract

Abstract: Exosomes are a kind of nanometer extracellular vesicle secreted by cells and they are able to transmit biological information in a long distance.Exosomes are secreted and released by cells,then transmitted in body fluids,finally swallowed in another cells to transmit biological information.Lipid metabolism has always been a hotspot of the field of life science research.Although there are many lncRNAs affecting lipid metabolism,there are relatively few lncRNAs studies affecting lipid metabolism in exosomes.For this reason,the study of exosomal-lncRNAs shows it’s necessity.As one of the important genetic material carried by the exosomes,the long non-coding RNAs are a kind of RNA molecule of which length for more than 200 nt,and perform many important biological functions such as transcriptional activation,chromatin modification and so on.In this paper,the biological characteristics of the exosomal-lncRNAs have been introduced,and the examples of the effect of exosomal-lncRNAs on lipid metabolism by different molecular mechanisms have been listed.The lipid metabolism disease caused by the abnormal expression of exosomal-lncRNAs has analyzed,and the principle of the exosomal-lncRNA acted as lipid metabolism disease’s biomarker has also illustrated.Finally,the prospect of exosomal-lncRNA as a biomarker for animal fat deposition has prospected.If more exosome-derived lncRNAs are detected in the future research,and it’s sufficiently to label abnormal conditions of lipid metabolism,there will undoubtedly be positive implications for the prediction and regulation of fat deposition in livestock.

Key words: exosomes; long non-coding RNA (lncRNA); lipid metabolism

CLC Number:

ZHANG Jiasu, XIA Guangjun, YIN Baozhen, ZHANG Luomeng, SHAO Jing, GENG Chunyin. Research Progress on the Regulation Mechanism of Exosomal lncRNA on Lipid Metabolism[J]. China Animal Husbandry & Veterinary Medicine, 2020, 47(4): 1028-1034.

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Research Progress on the Regulation Mechanism of Exosomal lncRNA on Lipid Metabolism

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