溶瘤病毒在犬肿瘤治疗中的研究进展

doi:10.16431/j.cnki.1671-7236.2020.03.037

Abstract

Abstract: Oncolytic virotherapy is a promising new biological therapy for the treatment of malignant tumors using viruses.The oncolytic virus not only directly infects and dissolves tumor cells,but also stimulates the immune response at the tumor site,to indirectly dissolve the tumor tissue cells,and has no killing or wake killing effect on normal tissue cells,thus achieving satisfying anti-tumor effect.In this paper,the development history of oncolytic virus and the mechanism of tumor ablation mediated by oncolytic virus were reviewed.Then we analyzed the killing effect on various canine tumor cells in vitro,in xenotransplantation tumor animal model and in dogs with tumor of eight oncolytic viruses including measles virus,canine distemper virus,Newcastle disease virus and Sendai virus and so on.Some encouraging results suggested that oncolytic virotherapy might become a safe and reliable new method for the treatment of malignant tumors.However,in order to apply oncolytic virotherapy in the clinical treatment of canine tumors,many problems still need to be solved,such as how to ensure the specificity of the virus,and how to determine the dose of the virus.In summary,this article provided new ideas and technical approaches for the safe use of oncolytic viruses in the clinical treatment of canine tumors.

Key words: oncolytic virus; canine tumor; treatment

CLC Number:

R730.5

REN Xiaoli, FAN Yuying, JIN Shuangxing, ZHANG Lei, LIU Yun, SHI Dongmei. Research Progress on Oncolytic Viruses in Canine Tumor Treatment[J]. China Animal Husbandry & Veterinary Medicine, 2020, 47(3): 965-971.

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Research Progress on Oncolytic Viruses in Canine Tumor Treatment

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