替米考星在酸碱溶液中的稳定性研究

China Animal Husbandry & Veterinary Medicine ›› 2010, Vol. 37 ›› Issue (12): 244-245.

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The Stability of Tilmicosin in Acid and Alkali

WU Li，CHEN Bao-ni，FENG Bao-yi，LI Mei-di，ZHUO Qu

(Experimental Veterinary Drug Plant, South China Agricultural University，Guangzhou 510642, China)

Received:1900-01-01 Revised:1900-01-01 Online:2010-12-20 Published:2010-12-20

Abstract

Abstract: In order to optimize the stability of Tilmicosin in acid and alkali, the contents of Tilmicosin were determined by HPLC to estimate the degradation of Tilmicosin in different pH conditions. The results showed that Tilmicosin was stable in pH 2 to 7.4.The degradations of Tilmicosin in pH 0.5 and pH 13 were 11.4% and 50.2%, respectively. Tilmicosin was not stable in concentrated acid and alkali,it would be partial degradable.

Key words: Tilmicosin; acid; alkali; stability; HPLC

CLC Number:

TQ463

WU Li;CHEN Bao-ni;FENG Bao-yi;LI Mei-di;ZHUO Qu. The Stability of Tilmicosin in Acid and Alkali[J]. China Animal Husbandry & Veterinary Medicine, 2010, 37(12): 244-245.

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The Stability of Tilmicosin in Acid and Alkali

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