支持细胞对精原干细胞自我更新和分化调控机制研究进展

doi:10.16431/j.cnki.1671-7236.2025.09.002

Abstract

Abstract: Spermatogenesis is a critical process in mammalian reproduction,in which spermatogonial stem cells (SSCs) play an indispensable role.As the central cells in spermatogenesis,Sertoli cells (SCs) not only provide physical support and a stable microenvironment for SSCs but also intricately regulate their proliferation,differentiation,apoptosis,and immune privilege by secreting various cytokines and signaling molecules.This complex interplay significantly influences the self-renewal and differentiation of SSCs.This review focuses on the mechanisms by which SCs regulate SSCs development,aiming to offer new perspectives and insights for SSCs research and to advance its applications in reproductive biology and clinical practice.

Key words: Sertoli cells; spermatogonial stem cells; self-renewal; differentiation

CLC Number:

S814.1

ZHU Lina, AN Xuejiao, YUE Yaojing. Research Progress on the Mechanisms of Sertoli Cell Regulation of Spermatogonial Stem Cell Self-renewal and Differentiation[J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(9): 4021-4031.

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Research Progress on the Mechanisms of Sertoli Cell Regulation of Spermatogonial Stem Cell Self-renewal and Differentiation

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