鸡球虫病流行病学特征及植物提取物在其防治中的应用

doi:10.16431/j.cnki.1671-7236.2025.02.035

Abstract

Abstract: Chicken coccidiosis is a kind of parasitic disease which is caused by many coccidids of Eimeria mainly parasitizing intestinal epithelial cells,which seriously threatens the intestinal health of chickens.The severity of the disease is closely related to the variety and age of the host chickens,feeding management,feed nutrition,coccidia species,infection dose and other factors.Anticoccidiosis drugs are the main means to prevent and control coccidiosis,but drug resistance and drug residues are easy to appear in food safety problems. In recent years,plant extracts have attracted much attention in coccidiosis control due to their natural safety and nutritional health advantages.Plant extracts can intervene in different stages of coccidiosis life cycle to control coccidiosis,such as inhibiting the development of coccidiosis,destroying the physiological structure of coccidiosis,destroying the morphology of oocysts,so as to improve the antioxidant properties of chicken intestinal tract,improve its production performance and feed conversion efficiency.On the basis of not producing drug resistance,plant extracts can effectively control the spread of coccidia,reduce the harm of coccidia,enhance the immunity,and regulate the intestinal microflora.The author systematically reviewed the etiology of chicken coccidiosis,the factors affecting the severity of coccidiosis,and the application effect and mechanism of common plant extracts in the prevention,treatment and immune regulation of chicken coccidiosis,aiming to provide reference for the development and application of plant extracts in the prevention and control of chicken coccidiosis.

Key words: chicken coccidiosis; Eimeria; plant extract; prevention

CLC Number:

S855.9

LIN Yongxin, HUANG Aolin, ZHANG Zhenyi, ZHANG Huaqi, YANG Zhiling, ZHU Yongwen. Epidemiological Characteristics of Chicken Coccidiosis and Application of Plant Extracts in Its Prevention[J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(2): 855-863.

References

[1] MOHAMED E A E,MOHAMED T E,ABDELRAZEQ M S,et al.Approaches to prevent and control Campylobacter spp.colonization in broiler chickens:A review[J].Environmental Science and Pollution Research International,2021,28(5):4989-5004.
[2] BLAKE D P,KNOX J,DEHAECK B,et al.Re-calculating the cost of coccidiosis in chickens[J].Veterinary Research,2020,51(1):115.
[3] NOGUEIRA V A,FRANCA T N,PEIXOTO P V.Ionophore poisoning in animals[J].Pesquisa Veterinaria Brasileira,2009,29(3):191-197.
[4] ALAGAWANY M,EL-SAADONY M T,ELNESR S S,et al.Use of lemongrass essential oil as a feed additive in quail’s nutrition:Its effect on growth,carcass,blood biochemistry,antioxidant and immunological indices,digestive enzymes and intestinal microbiota[J].Poultry Science,2021,100(6):101172.
[5] 张思新,汤新明,李超,等.我国鸡球虫病疫苗研究进展[J].寄生虫与医学昆虫学报,2018,25(4):254-261.ZHANG S X,TANG X M,LI C,et al.Progress in coccidiosis vaccine development for chickens in China[J].Acta Parasitologica et Medica Entomologica Sinica,2018,25(4):254-261.(in Chinese)
[6] ALLEN P C,JENKINS M C,MISKA K B.Cross protection studies with Eimeria maxima strains[J].Parasitology Research,2005,97(3):179-185.
[7] KIM W H,CHAUDHARI A A,LILLEHOJ H S.Involvement of T cell immunity in avian coccidiosis[J].Frontiers in Immunology,2019,10:2732.
[8] 秦梅,汤新明,龚玉姣,等.鸡球虫病疫苗研发新思考[J].中国农业大学学报,2023,28(6):1-11.QIN M,TANG X M,GONG Y J,et al.Rethinking novel anticoccidial vaccine design[J].Journal of China Agricultural University,2023,28(6):1-11.(in Chinese)
[9] SHARMAN P A,SMITH N C,WALLACH M G,et al.Chasing the golden egg:Vaccination against poultry coccidiosis[J].Parasite Immunology,2010,32(8):590-598.
[10] ABOU-KASSEM D E,MAHROSE K M,EL-SAMAHY R A,et al.Influences of dietary herbal blend and feed restriction on growth,carcass characteristics and gut microbiota of growing rabbits[J].Italian Journal of Animal Science,2021,20(1):896-910.
[11] EL-SAADONY M T,ZABERMAWI N M,ZABERMAWI N M,et al.Nutritional aspects and health benefits of bioactive plant compounds against infectious diseases:A review[J].Food Reviews International,2023,39(4):2138-2160.
[12] MOHAMED E A E,BOTHAINA A A,REEM M F,et al.Impacts of supplementing broiler diets with biological curcumin,zinc nanoparticles and Bacillus licheniformis on growth,carcass traits,blood indices,meat quality and cecal microbial load[J].Animals,2021,11(7):1878.
[13] MUTHAMILSELVAN T,KUO T,WU Y,et al.Herbal remedies for coccidiosis control:A review of plants,compounds,and anticoccidial actions[J].Evidence-Based Complementary and Alternative Medicine,2016,6:2657981.
[14] ABD EL-HACK M E A,EL-SAADONY M T,SHAFI M E,et al.Antimicrobial and antioxidant properties of chitosan and its derivatives and their applications:A review[J].International Journal of Biological Macromolecules,2020,164:2726-2744.
[15] ABDELNOUR S A,SWELUM A A,SALAMA A,et al.The beneficial impacts of dietary phycocyanin supplementation on growing rabbits under high ambient temperature[J]. Italian Journal of Animal Science,2020,19(1):1046-1056.
[16] BLAKE D P,MARUGAN-HERNANDEZ V,TOMLEY F M.Spotlight on avian pathology:Eimeria and the disease coccidiosis[J].Avian Pathology,2021,50(3):209-213.
[17] SHIRLEY M W,SMITH A L,TOMLEY F M.The biology of avian Eimeria with an emphasis on their control by vaccination[J].Advances in Parasitology,2005,60:285-330.
[18] 李超,顾小龙,卢春霞,等.我国鸡球虫病流行病学研究进展[J].寄生虫与医学昆虫学报,2018,25(4):230-241.LI C,GU X L,LU C X,et al.Studies on the prevalence of chicken coccidiosis in China[J].Acta Parasitologica et Medica Entomologica Sinica,2018,25(4):230-241.(in Chinese)
[19] WILLIAMS R B,CATCHPOLE J.A new protocol for a challenge test to assess the efficacy of live anticoccidial vaccines for chickens[J].Vaccine,2000,18(13):1178-1185.
[20] FREITAS L F V,SAKOMURA N K,REIS M P,et al.Coccidiosis infection and growth performance of broilers in experimental trials:Insights from a Meta-analysis including modulating factors[J].Poultry Science,2023,102(11):103021.
[21] LEE S H,DONG X,LILLEHOJ H S,et al.Comparing the immune responses of two genetically B-complex disparate Fayoumi chicken lines to Eimeria tenella[J].British Poultry Science,2016,57(2):165-171.
[22] LILLEHOJ H S.Role of T lymphocytes and cytokines in coccidiosis[J].International Journal for Parasitology,1998,28(7):1071-1081.
[23] AL-NATOUR M Q,SULEIMAN M M,ABO-SHEHADA M N.Flock-level prevalence of Eimeria species among broiler chicks in Northern Jordan[J].Preventive Veterinary Medicine,2002,53(4):305-310.
[24] BACHAYA H A,RAZA M A,KHAN M N,et al.Predominance and detection of different Eimeria species causing coccidiosis in layer chickens[J].Journal of Animal and Plant Sciences,2012,22(3):597-600.
[25] OLA-FADUNSIN S D.Investigations on the occurrence and associated risk factors of avian coccidiosis in Osun state,Southwestern Nigeria[J].Journal of Parasitology Research,2017,2017:9264191.
[26] SEDEIK M E,EL-SHALL N A,AWAD A M,et al.Identifying intra-specific variability in the virulence of Eimeria tenella using SCAR markers[J].International Journal of Poultry Science,2019,18(4):151-158.
[27] 张黎,郑龙龙,白冰,等.毒害艾美耳球虫山西株的分离和鉴定[J].中国兽医杂志,2023,59(2):34-38.ZHANG L,ZHENG L L,BAI B,et al.Isolation and identification of Eimeria necatrix Shanxi strain[J].Chinese Journal of Veterinary Medicine,2023,59(2):34-38.(in Chinese)
[28] 俞宁,杨琼,刘海燕,等.简便垫料法在生态鸡球虫病防治中的应用试验[J].中国兽医杂志,2019,55(8):106-107.YU Z,YANG Q,LIU H Y,et al.Application of simple padding method in ecological chicken coccidiosis control[J].Chinese Journal of Veterinary Medicine,2019,55(8):106-107.(in Chinese)
[29] AHAD S,TANVEER S,MALIK T A.Seasonal impact on the prevalence of coccidian infection in broiler chicks across poultry farms in the Kashmir valley[J].Journal of Parasitic Diseases,2015,39(4):736-740.
[30] CHEN Y,ZHANG H,CHENG Y,et al.Dietary L-threonine supplementation attenuates lipopolysaccharide-induced inflammatory responses and intestinal barrier damage of broiler chickens at an early age[J].British Journal of Nutrition,2018,119(11):1254-1262.
[31] 张利,华松.新型抗生素替代品抗菌肽在畜禽养殖上的应用[J].畜牧兽医杂志,2023,42(3):120-122.ZHANG L,HUA S.Application of antimicrobial peptides as new antibiotic substitutes in livestock and poultry breeding[J].Journal of Animal Science and Veterinary Medicine,2023,42(3):120-122.(in Chinese)
[32] EDDS G T,NAIR K P,SIMPSON C F.Effect of aflatoxin B₁ on resistance in poultry against cecal coccidiosis and Marek’s disease[J].American Journal of Veterinary Research,1973,34(6):819-826.
[33] 李瑜瑶,高品一,李丹琦,等.植物提取物对动物腹泻致病菌的抑菌作用及机制研究进展[J].动物营养学报,2024,36(3):1515-1524.LI Y Y,GAO P Y,LI D Q,et al.Research progress on bacteriostasis of plant extracts on pathogenic bacteria of animal diarrhea and its mechanism[J].Chinese Journal of Animal Nutrition,2024,36(3):1515-1524.(in Chinese)
[34] MUTHAMILSELVAN T,KUO T,WU Y,et al.Herbal remedies for coccidiosis control:A review of plants,compounds,and anticoccidial actions[J].Evidence-Based Complementary and Alternative Medicine,2016,6:2657981.
[35] ALFARO D M,SILVA A V F,BORGES S A,et al.Use of Yucca schidigera extract in broiler diets and its effects on performance results obtained with different coccidiosis control methods[J].The Journal of Applied Poultry Research,2007,16(2):248-254.
[36] KIM D K,LILLEHOJ H S,LEE S H,et al.Improved resistance to Eimeria acervulina infection in chickens due to dietary supplementation with garlic metabolites[J].The British Journal of Nutrition,2013,109(1):67-88.
[37] ERASMIA S,SKOUFOS I,MARUGAN-HERNANDEZ V.In vitro anticoccidial study of oregano and garlic essential oils and effects on growth performance,fecal oocyst output,and intestinal microbiota in vivo[J].Frontiers in Veterinary Science,2020,7:420.
[38] 张文飞,管武太,陈芳,等.青蒿素及其衍生物在畜禽生产中的应用研究进展[J].饲料工业,2019,40(15):22-27.ZHANG W F,GUAN W T,CHEN F,et al.Advances in the application of artemisinin and it’s derivatives in livestock and poultry production[J].Feed Industry,2019,40(15):22-27.(in Chinese)
[39] JIAO J Y,YANG Y Q,LIU M J,et al.Artemisinin and Artemisia annua leaves alleviate Eimeria tenella infection by facilitating apoptosis of host cells and suppressing inflammatory response[J].Veterinary Parasitology,2018,254:172-177.
[40] KAINGU F,LIU D,WANG L,et al.Anticoccidial effects of Aloe secundiflora leaf extract against Eimeria tenella in broiler chicken[J].Tropical Animal Health & Production,2017,49(4):823-828.
[41] ANDUALEM Y D,MULUBRIHAN R A.Anticoccidial activity of Aloe debrana and Aloe pulcherrima leaf gel against Eimeria oocysts[J].Journal of Parasitology Research,2020,1:8524973.
[42] FARAG M R,ALAGAWANY M.The role of Astragalus membranaceus as immunomodulator in poultry[J].World’s Poultry Science Journal,2019,75(1):43-54.
[43] WU S.Effect of dietary Astragalus membranaceus polysaccharide on the growth performance and immunity of juvenile broilers[J].Poultry Science,2018,97(10):3489-3493.
[44] LEE S H,LILLEHOJ H S,JANG S I,et al.Cinnamaldehyde enhances in vitro parameters of immunity and reduces in vivo infection against avian coccidiosis[J].The British Journal of Nutrition,2011,106(6):862-869.
[45] DALLOUL R A,LILLEHOJ H S,LEE J S,et al.Immunopotentiating effect of a Fomitella fraxinea-derived lectin on chicken immunity and resistance to coccidiosis[J].Poultry Science,2006,85(3):446-451.
[46] KASEM S M,MIRA N M,MAHFOUZ M E.In vitro study to evaluate the efficacy of ultrasonicated ethanolic extract of Rosmarinus officinalis and its chitosan-based nanoparticles against Eimeria tenella oocysts of chickens[J].AAPS PharmSciTech,2022,23(8):295.
[47] WANG Y,MCALLISTER T A,NEWBOLD C J,et al.Effects of Yucca schidigera extract on fermentation and degradation of steroidal saponins in the rumen simulation technique[J].Animal Feed Science and Technology,1998,74(2):143-153.
[48] GOPIKRISHNAN D,SELVARAJU M,PALANISAMY M,et al.Therapeutic efficacy of garlic,turmeric and eucalyptus extracts in the treatment of bovine endometritis[J].Indian Journal of Animal Research,2022,56(7):904-908.
[49] CACHO E D,GALLEGO M,IACUTE M,et al.Effect of artemisinin on oocyst wall formation and sporulation during Eimeria tenella infection[J]. Parasitology International,2010,59(4):506-511.
[50] 宋萍,苏洋洋,马庆涛,等.青蒿素与柳氮磺吡啶对柔嫩艾美尔球虫感染的疗效观察[J].中国兽医学报,2014,1(8):1337-1340.SONG P,SU Y Y,MA Q T,et al.Efficacy of artemisinin and SASP on chicken coccidiosis induced by Eimeria tenella[J].Chinese Journal of Veterinary Science,2014,1(8):1337-1340.(in Chinese)
[51] NAIDOO V,MCGAW L J,BISSCHOP S P R,et al.The value of plant extracts with antioxidant activity in attenuating coccidiosis in broiler chickens[J].Veterinary Parasitology,2008,153(3-4):214-219.
[52] WANG M L,SUO X,GU J H,et al.Influence of grape seed proanthocyanidin extract in broiler chickens:Effect on chicken coccidiosis and antioxidant status[J].Poultry Science,2008,87(11):2273-2280.
[53] ABBAS R Z,ABBAS A,IQBAL Z,et al.In vitro anticoccidial activity of Vitis vinifera extract on oocysts of different Eimeria species of broiler chicken[J].Journal of the Hellenic Veterinary Medical Society,2020,71(3):2267-2272.
[54] ALI M,CHAND N,KHAN R U,et al.Anticoccidial effect of garlic and ginger against experimentally induced coccidiosis in broiler chickens[J].Journal of Applied Animal Research,2019,47(1):79-84.
[55] ALJEDAIE M M,AL-MALKI E S.Anticoccidial activities of Salvadora persica,Zingiber officinale and Curcuma longa extracts on the control of chicken coccidiosis[J].Journal of King Saud University Science,2020,32(6):2810-2817.
[56] ABBAS A,IQBAL Z,ABBAS R Z,et al.In vivo anticoccidial effects of beta vulgaris in broiler chickens[J].Microbial Pathogenesis,2017,111:139-144.
[57] ALLEN P C,DANFORTH H D,AUGUSTINE P C.Dietary modulation of avian coccidiosis[J].International Journal for Parasitology,1998,28(7):1131-1140.
[58] JARAMILLO F X G,KIM D,LEE S H,et al.Role of oregano and citrus species-based essential oil preparation for the control of coccidiosis in broiler chickens[J].Journal of Animal Science and Biotechnology,2021,12(3):1089-1097.
[59] 李简.单宁酸对感染柔嫩艾美耳球虫鸡抗虫作用的初步研究[D].长春：吉林农业大学,2022.LI J.Study on the mechanism of tannic acid against infection with Eimeria tenella[D].Changchun：Jilin Agricultural University,2022.(in Chinese)
[60] HASSAN S M H,ZAYEDA R,ELAKANY H,et al.Anticoccidial activity of Aloe vera leafs’ aqueous extract and vaccination against Eimeria tenella:Pathological study in broilers[J]. Veterinary Research Communications,2023,48(1):403-416.
[61] ABDEL-TAWAB H,ABDEL-BAKI A S,EL-MALLAH A M,et al.In vivo and in vitro anticoccidial efficacy of Astragalus membranaceus against Eimeria papillata infection[J]. Journal of King Saud University Science,2020,32(3):2269-2275.
[62] LEE S H,LILLEHOJ E P,LEE K W,et al.Effects of dietary supplementation with phytonutrients on vaccine-stimulated immunity against infection with Eimeria tenella[J].Veterinary Parasitology,2011,181(2-4):97-105.
[63] RUIZ-IBANEZ M R,DEL R L,CATALA-GREGORI P,et al.Evaluating the efficacy of cinnamaldehyde and Echinacea purpurea plant extract in broilers against Eimeria acervulina[J].Veterinary Parasitology,2011,185(2-4):158-163.
[64] WANG Y,ZHANG Y,SHAO J,et al.Potential immunomodulatory activities of a lectin from the mushroom Latiporus sulphureus[J]. International Journal of Biological Macromolecules,2019,130:399-406.
[65] DALLOUL R A,LILLEHOJ H S,LEE J S,et al.Immunopotentiating effect of a Fomitella fraxinea-derived lectin on chicken immunity and resistance to coccidiosis[J].Poultry Science,2006,85(3):446-451.
[66] ISMAYA W T,TIANDRAWINATA R R，RACHMAWATI H.Lectins from the edible mushroom Agaricus bisporus and their therapeutic potentials[J].Molecules,2020,25(10):2368.
[67] ADIL S,MAGRAY S N.Impact and manipulation of gut microflora in poultry:A review[J].Journal of Animal and Veterinary Advances,2012,11(6):873-877.
[68] KASEM S M,MIRA N M,HELAL I B,et al.Prophylactic and therapeutic efficacy of ultrasonicated Rosmarinus officinalis ethanolic extract and its chitosan-loaded nanoparticles against Eimeria tenella infected broiler chickens[J].Acta Parasitologica,2024,69(1):951-999.

Epidemiological Characteristics of Chicken Coccidiosis and Application of Plant Extracts in Its Prevention

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	WANG Xueyang, LIN Zhan, LI Jiachen, XI Peng, ZHANG Hewei. Progress on Relationship Between Plant Extracts and Horizontal Transfer of Antibiotic Resistance Genes Carried by Plasmids [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(7): 3479-3488.
[2]	WANG Haotian, LI Junzhe, MEI Xiaoying, LI Longxian, LI Yingying, ZHANG Mingrui, WU Yi. Effects of Cuscuta chinensis and Arctium lappa Compound Plant Extracts on Urine Physicochemical,Serum Antioxidant and Immune Indexes in Adult Cats [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(6): 2531-2539.
[3]	YUAN Minggui, LI Yahui, HE Junheng, TANG Xinggang, BA Xiaomin, ZHAO Yajun, TIAN Ya, LAI Xingru, XIANG Rong, YANG Xi. Prevention Effect of Vitex negundo L.var.cannabifolia (Sieb.et Zucc.) Hand.-Mazz.Extract on Necrotic Enteritis in Broilers [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(6): 2736-2749.
[4]	ZHAO Haoran, MA Xin, WANG Jia, LIU Bo, ZHANG Yizhi, WANG Xiuli, YAO Wensheng, WEI Jin, LIU Yan. Research Progress on Mycoplasma synoviae Infection in Chickens [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(6): 2946-2954.
[5]	XING Zhongying, XU Xiang, ZHANG Chuntao, TU Yan, Rehman, DIAO Qiyu, WU Qiujue. Effects of Iicorice,Picrasma quassioides Extract and Montmorillonite on Digestive Metabolism,Rumen Fermentation Parameters and Microbial Composition of Lactating Calves [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(4): 1603-1615.
[6]	ZHU Bin, ZHOU Xingyou, WUJunquan, CHEN Huiying, ZHUJianfeng, QIJiaojiao, HU Wenfeng, YANG Meiyan. Phage Therapy in Mycoplasma Disease Management:Advances in Prevention and Treatment Strategies for Livestock and Poultry [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(4): 1763-1775.
[7]	ZHOU Na, LI Caishan, ZHAO Xueqing, ABUDUKADIER· Mejiti, DENG Yuqian, LIU Shiyu, SHI Wenyu, GUO Qingyong, BAYINGCHAHAN· Gailike. PCR Detection and Genetic Diversity Analysis of Theileria of Sheep in Aksu,Xinjiang [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(3): 1292-1300.
[8]	LI Aifang, WANG Qianfang, WANG Zilong, LI Yalan, XU Peng, FENG Shuying. Research Progress on Diagnosis and Control of Chinese Sacbrood Disease [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(2): 864-873.
[9]	GUO Jiajia, NIE Jing, QU Jiu, Danzengzhandu, LI Xiaowei, JIANG Mingfeng, LIU Yili. Mechanism of Antibacterial Action of Antimicrobial Peptides and Their Application in Livestock and Poultry [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(2): 934-945.
[10]	YANG Fan, ZHOU Jun, LI Qiting, LIN Qiaoer, LIANG Weijia, CAI Shikai, QIN Limei. Preventive and Therapeutic Effects of Chushi Lifei Xiaodusan on Infectious Bronchitis in Chickens [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(1): 481-490.
[11]	HE Zhenwen, LIU Dingyu, LIU Baoling, ZHANG Pian, WANG Xiaohu, WANG Gang, HUANG Yuan, CHEN Jing, DU Zongliang, CAI Rujian. Research Progress on Cross-species Transmission and Prevention and Control Techniques of Hepatitis E Virus [J]. China Animal Husbandry & Veterinary Medicine, 2024, 51(6): 2605-2620.
[12]	WU Wei, HAO Fei, XIE Xing, FENG Zhixin. Research Progress on Atomized Vaccines [J]. China Animal Husbandry & Veterinary Medicine, 2024, 51(3): 1203-1213.
[13]	HU Junhao, LIU Jibing, ZHOU Jiali, MA Yue, ZHAO Hongxi. Progress on in vitro Culture of Bovine Coccidia [J]. China Animal Husbandry & Veterinary Medicine, 2024, 51(2): 700-708.
[14]	HE Yuqian, LIJing, LIU Shuqing, ZHU Lijie, LIU Fuxiao, WANG Qi. Advance in Swine Senecavirus A [J]. China Animal Husbandry & Veterinary Medicine, 2024, 51(10): 4616-4625.
[15]	PAN Xiaoting, LI Juan, CHEN Bing, LIU Junjie, QI Nanshan, LIAO Shenquan, LYU Minna, LIN Xuhui, CAI Haiming, HU Junjing, SONG Yongle, BAI Yinshan, SUN Mingfei. Research Progress on Chicken Coccidia in vitro Culture Models and Application [J]. China Animal Husbandry & Veterinary Medicine, 2024, 51(1): 292-301.