Abstract: Klebsiella pneumoniae(K.pneumoniae) is an opportunistic pathogen that exists widely in water, soil, plants, and the mucosal surfaces of mammals.When the body was weakened, the immunity of the body was decreased, or antimicrobial agents were prolonged use, which can cause various clinical infections in humans and animals.Although cases of K.pneumoniae infection in poultry, livestock, and wildlife have been reported with a high case-fatality rate, the infection caused by K.pneumoniae from animals has not received sufficient attention.K.pneumoniae has a wide virulence spectrum, mainly including capsule polysaccharide, lipopolysaccharide, fimbriae and siderophores.Various factors interacting with each other result in pathogenicity.K. pneumoniae often causes pneumonia, mastitis, metritis, cystitis, meningitis and septicemia in animal at veterinary clinics.In order to cope with the economic losses caused by Gram-negative bacteria infections such as K.pneumoniae, antibiotics such as beta-lactams, polymyxins, tetracyclines, aminoglycosides, and quinolones were widely used in animals, leading to the emergence of multiple-resistant strain from animal and the increasing resistance of K.pneumoniae.In addition, animals and their products were considered to be the reservoir of multi-resistant strains.And K.pneumoniae can spread between humans and animals or between animals.This paper reviewed the pathogenicity, virulence factors, drug resistance and control measure of K.pneumoniae, providing recommendations for further control and delay of the emergence and spread of drug-resistant bacteria, and providing instructions for the development of novel veterinary drugs or non-antibiotic alternatives.

Key words: animals; Klebsiella pneumoniae; pathogenicity; drug resistance