家鸡羽色性状遗传调控机制研究进展

doi:10.16431/j.cnki.1671-7236.2022.05.021

Abstract

Abstract: Birds in the natural world show abundant feather colors,which plays an important role in avoiding natural enemies,predation,courtship,and resisting ultraviolet rays.Research on the color traits of chicken feathers helps to strengthen the differentiation and identification of breeds.It is particularly important to establish distinctive marks between breeds and ensure the appearance of the same breed in breeding work.Feather color is an important part of genetic research on poultry phenotype,mainly determined by melanin and carotenoids.At present,most researches on the genetic regulation mechanism of chicken feather color traits focus on melanin-related pathways.Studies have shown that Wnt,KIT/KITL and EDN3/EDNRB signaling pathways have important regulatory effects on the growth,migration and differentiation of melanomas,and α-MSH/ASIP-MC1R signaling pathway is responsible for regulating the synthesis of melanin.Existing studies have shown that it can reveal the genetic regulation mechanism of various feather traits such as black feather,stippled feather,dominant white feather,recessive white feather,autosomal albinism,silver feather,sex-linked imperfect albinism,dark brown feather,lavender feather (grey feather),tyrosinase-independent recessive white feather,mottled feather and sex-linked barring feather (Lu Hua feather) by genome-wide genetic variation detection technology,mining genes and variation loci related to feather color traits.Additionally,the Turing pattern was used as a theoretical basis to explain the formation mechanism of complex feather patterns.By summarizing the genetic regulation mechanism of melanin-related regulatory pathways and Turing pattern on chicken’s feather color traits,the authors reviewed the related research on chicken’s feather color traits that have identified loci in recent year to provide insights into the research on the molecular mechanism of chicken’s feather color and the marker-assisted selection of chicken’s feather color traits in the breeding process.

Key words: chickens; feather color; gene regulation; molecular inheritance; Turing pattern; melanin

CLC Number:

S813.1

WU Rifu, QU Hao, YAN Xia, LUO Chenglong, WANG Yan, SHU Dingming. Research Progress on the Genetic Regulation Mechanism of Feather Color Traits in Domestic Chickens[J]. China Animal Husbandry & Veterinary Medicine, 2022, 49(5): 1806-1816.

References

[1] MITROFANOVA O,DEMENTEVA N,KRUTIKOVA A,et al.Association of polymorphic variants in MSTN,PRL,and DRD2 genes with intensity of young animal growth in pushkin breed chickens[J].Cytology and Genetics,2017,51(3):179-184.
[2] MOISEYEVA I G,ROMANOV M N,NIKIFOROV A A,et al.Studies in chicken genetics.Commemorating the 120th anniversary of the outstanding soviet geneticist as serebrovsky (1892-1948)[J].Russian Journal of Genetics,2012,48(9):869-885.
[3] NEGRO J J,BLASCO R,ROSELL J,et al.Potential exploitation of avian resources by fossil hominins:An overview from ethnographic and historical data[J].Quaternary International,2016,421:6-11.
[4] YANG L,DU X,WEI S,et al.Genome-wide association analysis identifies potential regulatory genes for eumelanin pigmentation in chicken plumage[J].Animal Genetics,2017,48(5):611-614.
[5] D'ALBA L,KIEFFER L,SHAWKEY M D.Relative contributions of pigments and biophotonic nanostructures to natural color production:A case study in budgerigar (Melopsittacus undulatus) feathers[J].Journal of Experimental Biology,2012,215(8):1272-1277.
[6] ROULIN A,DUCREST A L.Genetics of colouration in birds[A].Proceedings of the Seminars in Cell & Developmental Biology[C].2013.
[7] TSANG T F,CHAN B,TAI W C,et al.Gynostemma pentaphyllum saponins induce melanogenesis and activate cAMP/PKA and Wnt/β-catenin signaling pathways[J].Phytomedicine,2019,60:153008.
[8] HOU L,PANTHIER J J,ARNHEITER H.Signaling and transcriptional regulation in the neural crest-derived melanocyte lineage:Interactions between KIT and MITF[J].Development,2000,127(24):5379-5389.
[9] IMOKAWA G,ISHIDA K.Inhibitors of intracellular signaling pathways that lead to stimulated epidermal pigmentation:Perspective of anti-pigmenting agents[J].International Journal of Molecular Sciences,2014,15(5):8293-8315.
[10] SONG Y S,BALCOS M C,YUN H Y,et al.Erk activation by fucoidan leads to inhibition of melanogenesis in Mel-Ab cells[J].The Korean Journal of Physiology & Pharmacology,2015,19(1):29-34.
[11] PILLAIYAR T,MANICKAM M,JUNG S H.Recent development of signaling pathways inhibitors of melanogenesis[J].Cellular Signalling,2017,40:99-115.
[12] WOLF HORRELL E M,BOULANGER M C,D'ORAZIO J A.Melanocortin 1 receptor:Structure,function,and regulation[J].Frontiers in Genetics,2016,7:95.
[13] RODRIGUES A R,ALMEIDA H,GOUVEIA A M.Intracellular signaling mechanisms of the melanocortin receptors:Current state of the art[J].Cellular and Molecular Life Sciences,2015,72(7):1331-1345.
[14] STOLT C C,LOMMES P,HILLGÄRTNER S,et al.The transcription factor SOX5 modulates SOX10 function during melanocyte development[J].Nucleic Acids Research,2008,36(17):5427-5440.
[15] LE L,ESCOBAR I E,HO T,et al.SLC45A2 protein stability and regulation of melanosome ph determine melanocyte pigmentation[J].Molecular Biology of the Cell,2020,31(24):2687-2702.
[16] HELLSTRÖM A R,WATT B,FARD S S,et al.Inactivation of PMEL alters melanosome shape but has only a subtle effect on visible pigmentation[J].PLoS Genetics,2011,7(9):e1002285.
[17] NÄTT D,KERJE S,ANDERSSON L,et al.Plumage color and feather pecking-behavioral differences associated with PMEL17 genotypes in chicken (Gallus gallus)[J].Behavior Genetics,2007,37(2):399-407.
[18] LI W,SARTELET A,TAMMA N,et al.Reverse genetic screen for loss-of-function mutations uncovers a frameshifting deletion in the melanophilin gene accountable for a distinctive coat color in Belgian Blue cattle[J].Animal Genetics,2016,47(1):110-113.
[19] HAUPT Y,MAYA R,KAZAZ A,et al.MDM2 promotes the rapid degradation of P53[J].Nature,1997,387(6630):296-299.
[20] KIM S H,MITCHELL M,FUJII H,et al.Absence of p16INK4a and truncation of ARF tumor suppressors in chickens[J].Proceedings of the National Academy of Sciences,2003,100(1):211-216.
[21] SHARPLESS N E.INK4a/ARF:A multifunctional tumor suppressor locus[J].Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis,2005,576(1-2):22-38.
[22] LOPES R J,JOHNSON J D,TOOMEY M B,et al.Genetic basis for red coloration in birds[J].Current Biology,2016,26(11):1427-1434.
[23] PRICE WALDMAN R,STODDARD M C.Avian coloration genetics:Recent advances and emerging questions[J].Journal of Heredity,2021,112(5):395-416.
[24] TOOMEY M B,LOPES R J,ARAÚJO P M,et al.High-density lipoprotein receptor scarb1 is required for carotenoid coloration in birds[J].Proceedings of the National Academy of Sciences,2017,114(20):5219-5224.
[25] KERJE S,LIND J,SCHVTZ K,et al.Melanocortin 1-receptor (MC1R) mutations are associated with plumage colour in chicken[J].Animal Genetics,2003,34(4):241-248.
[26] KERJE S,SHARMA P,GUNNARSSON U,et al.The dominant white,dun and smoky color variants in chicken are associated with insertion/deletion polymorphisms in the PMEL17 gene[J].Genetics,2004,168(3):1507-1518.
[27] TOBITA-TERAMOTO T,JANG G,KINO K,et al.Autosomal albino chicken mutation (ca/ca) deletes hexanucleotide (-δGACTGG817) at a copper-binding site of the tyrosinase gene[J].Poultry Science,2000,79(1):46-50.
[28] CHANG C M,COVILLE J L,COQUERELLE G,et al.Complete association between a retroviral insertion in the tyrosinase gene and the recessive white mutation in chickens[J].BMC Genomics,2006,7:19.
[29] GUNNARSSON U,HELLSTRÖM A R,TIXIER B M,et al.Mutations in SLC45A2 cause plumage color variation in chicken and Japanese quail[J].Genetics,2007,175(2):867-877.
[30] GUNNARSSON U,KERJE S,BED'HOM B,et al.The dark brown plumage color in chickens is caused by an 8.3 kb deletion upstream of SOX10[J].Pigment Cell & Melanoma Research,2011,24(2):268-274.
[31] VAEZ M,FOLLETT S A,BED'HOM B,et al.A single point-mutation within the melanophilin gene causes the lavender plumage colour dilution phenotype in the chicken[J].BMC Genetics,2008,9(1):1-9.
[32] KINOSHITA K,AKIYAMA T,MIZUTANI M,et al.Endothelin receptor b2 (EDNRB2) is responsible for the tyrosinase-independent recessive white (mo^W) and mottled (mo) plumage phenotypes in the chicken[J].PLoS One,2014,9(1):e86361.
[33] HELLSTRÖM A R,SUNDSTRÖM E,GUNNARSSON U,et al.Sex-linked barring in chickens is controlled by the CDKN2A/B tumour suppressor locus[J].Pigment Cell & Melanoma Research,2010,23(4):521-530.
[34] SCHWOCHOW T D,RING H,SUNDSTRÖM E,et al.The evolution of sex-linked barring alleles in chickens involves both regulatory and coding changes in CDKN2A[J].PLoS Genetics,2017,13(4):e1006665.
[35] 封竣淇,徐伟,黄兰,等.MC1R基因的研究进展[J].中国畜牧兽医,2017,44(4):1141-1148. FENG J Q,XU W,HUANG L,et al.Research progress of MC1R gene[J].China Animal Husbandry & Veterinary Medicine,2017,44(4):1141-1148.(in Chinese)
[36] 杨永升,邓学梅,李宁,等.MC1R是控制鸡黑色素形成的候选主效基因[J].生物化学与生物物理进展,2004,31(6):500-505. YANG Y S,DENG X M,LI N,et al.MC1R is a candidate major gene controlling melanin formation in chickens[J].Progress in Biochemistry and Biophysics,2004,31(6):500-505.(in Chinese)
[37] SMYTH J J.Genetics of Plumage,Skin and Eye Pigmentation in Chickens[M].New York:Elsevier,1990.
[38] DÁVILA S,GIL M,RESINO TALAVÁN P,et al.Association between polymorphism in the melanocortin 1 receptor gene and E locus plumage color phenotype[J].Poultry Science,2014,93(5):1089-1096.
[39] LING M K,LAGERSTRÖM M C,FREDRIKSSON R,et al.Association of feather colour with constitutively active melanocortin 1 receptors in chicken[J].European Journal of Biochemistry,2003,270(7):1441-1449.
[40] KABIR M,TAKENOUCHI A,HAQANI M,et al.Discovery of a new nucleotide substitution in the MC1R gene and haplotype distribution in native and non-Japanese chicken breeds[J].Animal Genetics,2020,51(2):235-248.
[41] DENG Y,LI B,CHEN H,et al.Haplotypes of three missense mutations in melanocortin 1 receptor serve as genetic markers for black plumage in Chinese chicken[J].Animal Genetics,2020,51(5):842-843.
[42] ZHANG G W,LIAO Y,ZHANG W X,et al.A new dominant haplotype of MC1R gene in Chinese Black Plumage chicken[J].Animal Genetics,2017,48(5):624.
[43] 张细权,包世增.优质肉鸡羽色遗传及选择[J].养禽与禽病防治,1996,12:7-8. ZHANG X Q,BAO S Z.Inheritance and selection of feather color of high quality broilers[J].Poultry Husbandry and Disease Control,1996,12:7-8.(in Chinese)
[44] GUO X,LI X,LI Y,et al.Genetic variation of chicken MC1R gene in different plumage colour populations[J].British Poultry Science,2010,51(6):734-739.
[45] KARLSSON A C,KERJE S,ANDERSSON L,et al.Genotype at the PMEL17 locus affects social and explorative behaviour in chickens[J].British Poultry Science,2010,51(2):170-177.
[46] BRUMBAUGH J,BARGAR T,OETTING W.A "new" allele at the C pigment locus in the fowl[J].Journal of Heredity,1983,74(5):331-336.
[47] OETTING W,CHURILLA A,YAMAMOTO H,et al.C pigment locus mutants of the fowl produce enzymatically inactive tyrosinase-like molecules[J].Journal of Experimental Zoology,1985,235(2):237-245.
[48] KULIAWAT R,SANTAMBROGIO L.A mutation within the transmembrane domain of melanosomal protein silver (PMEL17) changes lumenal fragment interactions[J].European Journal of Cell Biology,2009,88(11):653-667.
[49] STURTEVANT A H.An experiment dealing with sex-linkageinfowls[J]. JournalofExperimental Zoology,1912,12(4):499-518.
[50] MOORE J W,SMYTH J R.Genetic factors associated with the plumage pattern of the barred fayoumi[J].Poultry Science,1972,51(4):1149-1156.
[51] BITGOOD J,SOMES R G.Linkage relationships and gene mapping[J].Developments in Animal and Veterinary Sciences (Netherlands),1990,1:469-496.
[52] BRUMBAUGH J,CHATTERJEE G,HOLLANDER W.Adendritic melanocytes:A mutation in linkage group Ⅱ of the fowl[J].Journal of Heredity,1972,63(1):19-25.
[53] XU J,XIE M,ZOU S,et al.Interactions of allele e of the MC1R gene with FM and mutations in the MLPH gene cause the five-gray phenotype in the Anyi Tile-like Gray chicken[J].Genetics and Molecular Research,2016,15(2):15027633.
[54] CAREFOOT W.Inheritance of the barred plumage pattern of the Silver Campine Fowl,together with its relationship to other patterned fowl[J].British Poultry Science,1999,40(2):217-220.
[55] ANDERSSON L,BED'HOM B,CHUONG C M,et al.The Genetic Basis for Pigmentation Phenotypes in Poultry[M].London:Burleigh Dodds Science Publishing,2020.
[56] DORSHORST B,ASHWELL C M.Genetic mapping of the sex-linked barring gene in the chicken[J].Poultry Science,2009,88(9):1811-1817.
[57] TURING A M.The chemical basis of morphogenesis[J].Bulletin of Mathematical Biology,1990,52(1):153-197.
[58] MARCON L,DIEGO X,SHARPE J,et al.High-throughput mathematical analysis identifies Turing networks for patterning with equally diffusing signals[J].Elife,2016,5:e14022.
[59] NAKAMASU A,TAKAHASHI G,KANBE A,et al.Interactions between zebrafish pigment cells responsible for the generation of Turing patterns[J].Proceedings of the National Academy of Sciences,2009,106(21):8429-8434.
[60] YUAN Y W,SAGAWA J M,FROST L,et al.Transcriptional control of floral anthocyanin pigmentation in monkey flowers (Mimulus)[J].New Phytologist,2014,204(4):1013-1027.
[61] DING B,PATTERSON E L,HOLALU S V,et al.Two myb proteins in a self-organizing activator-inhibitor system produce spotted pigmentation patterns[J].Current Biology,2020,30(5):802-814.
[62] PRUM R O,WILLIAMSON S.Reaction-diffusion models of within-feather pigmentation patterning[J].Proceedings of the Royal Society of London Series B:Biological Sciences,2002,269(1493):781-792.
[63] SCHWOCHOW T D,BORNELÖV S,JIANG T,et al.The feather pattern autosomal barring in chicken is strongly associated with segregation at the MC1R locus[J].Pigment Cell & Melanoma Research,2021,34(6):1015-1028.
[64] INABA M,JIANG T X,LIANG Y C,et al.Instructive role of melanocytes during pigment pattern formation of the avian skin[J].Proceedings of the National Academy of Sciences,2019,116(14):6884-6890.
[65] INABA M,CHUONG C M.Avian pigment pattern formation:Developmental control of macro-(across the body) and micro-(within a feather) level of pigment patterns[J].Frontiers in Cell and Developmental Biology,2020,8:620.
[66] LIN S,FOLEY J,JIANG T,et al.Topology of feather melanocyte progenitor niche allows complex pigment patterns to emerge[J].Science,2013,340(6139):1442-1445.
[67] HO W K,FREEM L,ZHAO D,et al.Feather arrays are patterned by interacting signalling and cell density waves[J].PLoS Biology,2019,17(2):e3000132.
[68] LI J Y,LEE M O,CHEN J,et al.Cis-acting mutation affecting GJA5 transcription is underlying the melanotic within-feather pigmentation pattern in chickens[J].Proceedings of the National Academy of Sciences,2021,118(41):e2109363118.
[69] HAUPAIX N,MANCEAU M.The embryonic origin of periodic color patterns[J].Developmental Biology,2020,460(1):70-76.
[70] CHEN C F,FOLEY J,TANG P C,et al.Development,regeneration,and evolution of feathers[J].Annual Review of Animal Biosciences,2015,3(1):169-195.

Research Progress on the Genetic Regulation Mechanism of Feather Color Traits in Domestic Chickens

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	LI Jun, YIN Lei, YANG Ying, HU Jianxin, TANG Li, QIN Qingming, LIANG Chengcheng, WU Haigang, ZHAO Mengting, DUAN Wenmiao. Effects of Different Fermentation Bedding Materials on Growth Performance, Digestive Enzyme Activities, Serum Biochemical and Immune Indices in Patridge Shank Chickens [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(7): 3047-3058.
[2]	TANG Li, DENG Kaiwei, HE Shuhai, LI Jun, QIN Qingming, LIANG Chengcheng, WU Haigang, HAN Xu, LU Jianing. Effects of Green Tea Aqueous Extract on Nutrient Apparent Metabolism Rate,Digestive Enzyme Activities and Serum Biochemical Indices of Cyan-shank Partridge chickens [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(6): 2552-2560.
[3]	XU Kuowei, LENG Tangjian, XIONG Bao, LI Jinyan, GUO Panjiang, WU Peifu, CHEN Fenfen, ZHOU Jielong. Whole-genome Selection Signal Analysis of Ninglang Plateau Chickens [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(5): 1941-1954.
[4]	ZHONG Min, YANG Xiaopei, LIU Ruiping, SONG Wenjing, ZHONG Yunping. Effect of Dietary Andrographis paniculata Extract Supplementation on the Growth Performance,Serum Biochemistries,and Gut Health in Ningdu Yellow Chickens [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(5): 2115-2127.
[5]	TIAN Yingping, DU Yun, JIANG Yaozhou, LIU Qinsong, ZHOU Xiaohong, WU Sheng, ZHAO Xudong, ZHANG Fuping. Study on the Growth and Development,Meat Performance and Their Correlation Analysis of Guizhou Recessive White-feather Chickens [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(5): 2208-2218.
[6]	ZHANG Zhengfei, TANG Anxing, SUN Jindong, FU Lixiang, WANG Xingxian, ZHANG Shiyun, YANG Liangyu, NIU Guoyi, TAO Linli. Study on the Appropriate Dietary Crude Protein Level of Yanjin Black-bone Chickens [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(4): 1543-1553.
[7]	LI Zhiyi, LI Jie, CHEN Chuwen, NONG Yi, WANG Jiayan, WANG Zi, WU Jinbo, LI Zhixiong. Analysis and Identification of miRNA in Leg Muscle Tissue of Tibetan Chicken Embryos at Different Developmental Stages [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(4): 1681-1693.
[8]	YANG Zhuliang, LUO Jintang, ZHANG Zhen, LI Jianneng, LI Fuqiu, YANG Xiurong. Genome-wide Association Study of Comb Traits in Nandan-Yao Chickens Based on the "GXChickChip-I" Chip [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(4): 1716-1728.
[9]	WU Min, XU Junjie, LI Xinxin, CHEN Yifan, WANG Dehe, HAO Erying, CHEN Hui, SHI Lei. Screening of Key Genes Regulating Muscle Development in Yellow-feathered Chickens Based on RNA-Seq [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(3): 990-1000.
[10]	WEI Ying, DUAN Yehui, DENG Jinping. Research Progress on the Application of Flavor Amino Acids in Pig and Chicken Production [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(3): 1089-1101.
[11]	GUO Qiqi, WEI Limin, XUE Chenlu, WU Wei, OUYANG Kun, LIU Yuhang, SUN Ruiping, LIU Quanwei. Effects of Cassava Meal on Production Performance,Serum Biochemical Parameters and Immune Indexes of Wenchang Chickens [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(2): 615-623.
[12]	SHAN Jing, DU Hanxiang, QU Xiangyong, GUO Songchang, LI Meichun, HE Changqing. Research Progress on the Application of Plant Essential Oil in Chicken Production [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(2): 668-677.
[13]	YANG Jinlin, LI Hui, ZHAO Depeng, SHI Yushi, LONG Xia, TAN Qisong. Polymorphisms of EDNRB2 Gene and Its Association with Skin Color Traits in Chishui Black-bone Chickens [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(2): 759-770.
[14]	TIAN Huihui, WANG Bingxin, ZHU Zhaoyan, YU Yange, DING Mengxia, TIAN Yadong, JIANG Ruirui, SUN Guirong, HAN Ruili, KANG Xiangtao, YAN Fengbin, GUO Yujie. Cloning,Bioinformatics Analysis of HSPA8 Gene and Its Expression Pattern in Thymus in Chickens [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(1): 39-51.
[15]	ZHANG Suhan, MAO Peichun, TIAN Xiaoxia, GUO Yuxia, ZHENG Mingli, MENG Lin. Effects of Grazing on Chicory Grassland Under Forest on Caecum Microflora and Metabolites of Beijing-You Chickens [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(1): 133-146.