中性粒细胞胞外诱捕网与病原体的相互作用及其机制

doi:10.16431/j.cnki.1671-7236.2021.04.026

Abstract

Abstract: As an important component of innate immune system,neutrophils play a critical role in defense against infection with pathogens.One of the mechanisms by which neutrophils play a defensive role is to capture and destroy pathogens by releasing neutrophil extracellular traps (NETs).However,some pathogens have evolved the escaping mechanisms,and cause a persistent damage in organism.In addition,abnormal NETs can also lead to an organism damage.Recently,NETs has become a focus of research in neutrophil function,and has been widely studied worldwide.Some researchers have found that the reticular structure released from avian heterophiles is similar to that of mammalian NETs,and named it heterophil extracellular traps (HETs).In this review,the authors summarized the mechanisms by which NETs resist pathogen invasion and pathogens escape from NETs,and the pathogenesis caused by interaction between NETs and pathogens.

Key words: neutrophil extracellular traps (NETs); pathogens; immune escape; immune damage

CLC Number:

S852.4⁺2

XU Lifeng, ZHANG Baoge, HONG Jinxuan, WANG Xuhui, CHEN Jilong, LI Xunliang. Interaction Between Neutrophil Extracellular Traps and Pathogens and Its Underlying Mechanism[J]. China Animal Husbandry & Veterinary Medicine, 2021, 48(4): 1388-1395.

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Interaction Between Neutrophil Extracellular Traps and Pathogens and Its Underlying Mechanism

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