RNA N6-腺苷酸甲基化修饰及其生物学功能

doi:10.16431/j.cnki.1671-7236.2021.04.006

Abstract

Abstract: N⁶-methylation modification (N⁶-methyladenosine,m⁶A) is a post-transcriptional modification of eukaryotic mRNA,which is a dynamic and reversible process,catalyzed by methyltransferases,demethylases and binding proteins.It can mediate various biological processes of eukaryotes and participate in the regulation of various cellular gene expression and pathological processes of diseases.With the continuous deepening of people's understanding of RNA modification and the development of high-throughput sequencing technology in recent years,people are increasingly exploring the biological functions of m⁶A methylation modification in cell differentiation,animal growth and development,and disease occurrence.This article introduced the characteristics of m⁶A methylation modification and its related three enzymes,detection technology of m⁶A modification,as well as its biological functions in mRNA regulation,stem cell differentiation,tumorigenesis and metastasis,and a brief overview of m⁶A methylation modification regulating the growth and development of livestock and poultry animals such as pigs and chickens.Finally,the future research direction and development prospects of m⁶A methylation modification were prospected,with a view to the subsequent m⁶A methylation modification in the animal life process,in order to provide references for in-depth research and application in the prevention and treatment of diseases.

Key words: RNA methylation modification; m⁶A; methyltransferase; demethylase; reading protein

CLC Number:

Q752

ZOU Juhong, HUANG Yanna, JIANG Qinyang. RNA m⁶A Methylation Modification and Its Biological Function[J]. China Animal Husbandry & Veterinary Medicine, 2021, 48(4): 1196-1203.

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RNA m⁶A Methylation Modification and Its Biological Function

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RNA m6A Methylation Modification and Its Biological Function

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RNA m⁶A Methylation Modification and Its Biological Function