Abstract: Parasitic diseases have a considerable socio-economic impact,zoonotic parasites bring a huge burden of disease to people and cause serious economic losses to the breeding industry.Therefore,the prevention and treatment of parasitic diseases is an urgent research topic.Parasites have many forms of immune evasion mechanisms.Inactivated vaccines,live attenuated vaccines,subunit vaccines,etc.have not achieved effective prevention of parasitic diseases.Many studies have shown that DNA vaccines are expected to be the prevention and effective treatment of parasitic diseases.DNA vaccine is a new type of vaccine which can simultaneously produce long-lasting durable humoral and cellular immune,and it provide protective immunity by expressing foreign proteins in the host.DNA vaccines are different from other subunit vaccines in that immunogens are synthesized in the host by cells that take up the DNA encoding the antigen.The synthesis of protein in the body can also carry out antigen processing,modification and presentation to the host's immune system,similar to the way of natural infection.This article discussed the immune mechanism,design principles,immune pathways,advantages and disadvantages of DNA vaccines and the research progress of parasite DNA vaccines in recent years.It was expected to theoretical reference for the control of parasites disease.

Key words: parasites DNA vaccine; immune mechanism; design principles; immune pathway