MYH3基因在动物肌肉发育、能量代谢及生产性能中的研究进展

doi:10.16431/j.cnki.1671-7236.2020.10.026

Abstract

Abstract: Myosin heavy chain 3 (MYH3) gene encoded an embryonic myosin heavy chain protein that controlled the traction and sliding of muscles.MYH3 gene was an important marker gene for muscle differentiation,could regulated muscle development and energy metabolism,and played an important role in the entire muscle development of animals. MYH3 gene was highly conserved among different species and expressed in many tissues in animals,and it was highly expressed during embryonic muscle tissue and muscle regeneration.It was affected by various factors such as transcription factors,microRNA,lncRNA and environmental nutrition factors,and also regulated the funtion of other genes.MYH3 gene mutation could also change the phosphorylation level of TGF-β signaling pathway and MAPK signaling pathway related proteins.After mutation of MYH3 gene,it would affect the activity of ATPase,prolong the hydrolysis time of ATP and the cycle of transverse bridge,which could affect the energy metabolism of muscle and eventually lead to the disease of muscle energy metabolism.The change of copy number or expression level of MYH3 gene was significantly correlated with the size,carcass weight,slaughter weight and growth performance of animals.MYH3 gene was highly expressed in muscle tissues with high marbling and high intramuscular fat,and also to be considered an important candidate gene affecting muscle tenderness,shear strength and red flesh color of muscle in animals.The high expression of MYH3 gene was related to the content of oxidized type Ⅰ muscle fibers,diameter of muscle fibers and content of slow muscle fibers.This article introduced the basic structural characteristics of MYH3 gene,pointed out its regulatory role with muscle tissue development and related influencing factors,and then explained the relationship between MYH3 gene and animal muscle energy metabolism,growth performance and meat quality,which provided a reference for further research on MYH3 gene and muscle development regulation and meat quality improvement.

Key words: MYH3 gene; muscle development; energy metabolism; production performance

CLC Number:

Q789

DAI Yuxing, SHENG Zhikang, CHU Han, LIU Zhe, CHEN Yuee(Noppanun Poubol), HONG Liang, PU Lei, GUO Liang. Research Progress on MYH3 Gene in Animal Muscle Development, Energy Metabolism and Production Performance[J]. China Animal Husbandry & Veterinary Medicine, 2020, 47(10): 3270-3277.

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Research Progress on MYH3 Gene in Animal Muscle Development, Energy Metabolism and Production Performance

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