3'UTR在基因表达调控中的作用

doi:10.16431/j.cnki.1671-7236.2016.11.015

Abstract

Abstract:

In eukaryotes,the regulation of gene expression plays an important role in the growth and development of organisms which is a multistep process that involves the transcription,translation and turnover of messenger RNAs（mRNA）and proteins.Researches have showed that the 3'untranslated region（3'UTR）of mRNA is emerging as critically important in regulating gene expression at post transcriptional levels.mRNA stability,localization and translation are largely determined by sequences in the 3'UTR.The aberrant regulation of 3'UTR will result in aberrant levels of expressed protein, enhancing metabolic changes and leading to disease.The researches of 3'UTR in the regulation of gene expression,human diseases and animal production were summarized and discussed in this paper to provide the reference for applications of 3'UTR in human disease diagnosis and treatment and animal performance.

Key words: 3'UTR; mRNA; gene expression regulation

CLC Number:

Q786

YU Shi-gang, WANG Gang. Role of 3' Untranslated Region（3'UTR）in the Regulation of Gene Expression[J]. China Animal Husbandry & Veterinary Medicine, 2016, 43(11): 2907-2913.

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Role of 3' Untranslated Region（3'UTR）in the Regulation of Gene Expression

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