人工设计天蚕素抗菌肽AMP-D及其活性测定

Abstract

Abstract: By the experiment of antimicrobial peptides structure optimization and solid-phase synthesis technology of synthetic,new antibacterial peptide AMP-D could be obtained. According to determination of its activity and hemolytic, the experimental results showed that AMP-D could inhibit the growth of Gram-positive bacteria, and was no hemolytic activity. Minimal inhibitory concentration of AMP-D was 10.5 μg/mL against Staphylococcus aurous. The antimicrobial activities of AMP-D had more improve than the original peptide.

Key words: cecropin; AMP-D; antibacterial activity; hemolytic

CLC Number:

HAN Jin-hui, ZHAI Pei, SHI Yong-hui. Artificial Design Cecropins of AMP-D and Determination of Activity[J]. China Animal Husbandry & Veterinary Medicine, 2012, 39(7): 159-162.

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Artificial Design Cecropins of AMP-D and Determination of Activity

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