China Animal Husbandry & Veterinary Medicine ›› 2026, Vol. 53 ›› Issue (1): 27-38.doi: 10.16431/j.cnki.1671-7236.2026.01.003

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Mechanism of the Combined Action of Bacillus coagulans and Clostridium butyricum and Its Application in Poultry and Pig Production

LIU Feilong(), MA Jie, ZHANG Xinhao, GAO Aiqin()   

  1. College of Animal Science and Technology,Inner Mongolia Agricultural University,Hohhot 010018,China
  • Received:2025-05-13 Online:2026-01-05 Published:2025-12-26
  • Contact: GAO Aiqin E-mail:2896342452@qq.com;gaoaiqin999@163.com

Abstract:

In the context of the comprehensive ban on the addition of growth-promoting antibiotics in feed, finding safe and effective antibiotic alternatives is the research focus of the livestock industry. Probiotics have gained prominence due to their green nature, lack of harmful substances, and excellent efficacy. Bacillus coagulans (BC), integrating functional traits of lactic acid bacteria and Bacillus, stabilizes intestinal micro-ecological homeostasis, enhances immune responses, and improves nutrient utilization efficiency in animals. Clostridium butyricum (CB), as a Gram-positive anaerobic Bacillus, plays a key role in regulating the intestinal flora,short-chain fatty acid metabolism,and anti-inflammation and antioxidant due to its biological characteristics such as resistance,alkali resistance and heat resistance. The author briefly described the functions of the two types of probiotics, and analyzed the combined mechanism of their effects on improving animal growth performance, optimizing the structure of the intestinal flora, and enhancing immune function. The progress of the combined application of the two types of bacteria in poultry and pig production was reviewed. In order to provide a theoretical basis for the precise matching and in-depth development of future composite probiotics.

Key words: Bacillus coagulans; Clostridium butyricum; combined action; microbial homeostasis; gut microbiota

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