China Animal Husbandry & Veterinary Medicine ›› 2025, Vol. 52 ›› Issue (9): 4114-4122.doi: 10.16431/j.cnki.1671-7236.2025.09.010

• Nutrition and Feed • Previous Articles    

Research Progress on the Protective Effect of Resveratrol in Mycotoxin-induced Liver Injury in Livestock

LI Haonan, LI Jiahui, YANG Fan, WEI Wenjuan, LYU Qiongxia, ZHANG Ziqiang, LIU Yumei, CHEN Xiaoguang   

  1. College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471023, China
  • Received:2025-01-21 Published:2025-08-29

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Abstract: Mycotoxins (MCTs) are the toxic secondary metabolites produced by fungi such as Aspergillus and Fusarium in moldy grains and feeds,contaminate over 50% of cereal feeds in the intensive farming.The toxins can enter the bodies of livestock through the food chain,causing damage to multiple organs including the liver,kidney,and immune system.Notably,as a key metabolic and detoxifying organ,the liver is the most significantly affected.Representative MCTs such as aflatoxin B1 (AFB1),zearalenone (ZEA),and deoxynivalenol (DON) can induce hepatocyte necrosis,steatosis,inflammatory infiltration and other pathological changes,seriously endangering livestock health and reducing farming profitability.Resveratrol (Res),a natural polyphenolic compound derived from peanuts,grapes and other plants,has great potential in mitigating MCTs toxicity due to its remarkable antioxidant,anti-inflammatory and anti-apoptotic properties in recent years.The protective effects are achieved through multi-pathway synergistic mechanisms.For instance,in terms of antioxidant activity,Res activates antioxidant enzymes (SOD,CAT,etc.),and neutralize toxin-induced free radicals to alleviate oxidative stress mainly through the Nrf2/Keap1 signaling pathway.In terms of anti-inflammatory effects,Res suppresses the NF-κB pathway and upregulates SIRT1 expression,thereby reducing pro-inflammatory cytokines (TNF-α and IL-6) and mitigating hepatic inflammation.Additionally,Res exerts anti-apoptotic effect by regulating the Bcl-2/Bax value,inhibiting the Caspase cascades,and promoting mitochondrial autophagy to prevent hepatocyte apoptosis and protect the liver.The author systematically summarizes the protective effects and the molecular mechanisms of Res against MCTs-induced liver damage in livestock,aiming to provide a theoretical basis for its application in alleviating MCTs-induced liver damage in livestock,and offer scientific support for it potential as a novel feed additive.

Key words: resveratrol; mycotoxins; liver injury; oxidative stress; inflammation; cell apoptosis

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