抗菌肽的性质、功能及优化策略研究进展

doi:10.16431/j.cnki.1671-7236.2025.07.035

Abstract

Abstract: In recent years,the use of antimicrobials has faced serious challenges,and the continuous increase of multi-drug-resistant microorganisms has severely limited the use of antimicrobials.The mechanism of bacterial resistance is complex and varied,and the development and production of new antimicrobials is time-consuming and costly.Therefore,it is particularly important to explore alternative therapies to treat drug-resistant bacterial infections.Antimicrobial peptides (AMPs),as a kind of unique and diverse small molecular peptides,have the characteristics of broad antibacterial spectrum,antiviral,not easy to produce drug resistance,immune regulation,etc.,and have shown great potential in the treatment of drug-resistant bacterial diseases.However,AMPs faces many challenges in clinical application,such as high toxicity to host cells and easy degradation by proteases.Researchers are actively exploring a variety of strategies to optimize the structural design of AMPs in order to improve their biological activity while reducing adverse reactions.In this paper,the origin,structural properties and mechanism of AMPs are described.The recent breakthroughs in improving the activity of AMPs are discussed,including amino acid residue replacement,recombinant fragment design,heterozygous peptide construction,incorporation of unnatural amino acids and other chemical modifications.At the same time,the potential value of AMPs combined with conventional antibiotics,lysozyme and nanomaterials was analyzed，in order to provide a theoretical basis for the development and application of AMPs in the fields of medical health,agriculture and food safety.

Key words: antimicrobial peptides(AMPs); properties; functions; optimization strategies

CLC Number:

S859.79^＋7

LIANG Lina, ZHI Yan, WU Yungerzele, HU Ge. Research Progress on Properties, Functions and Optimization Strategies of Antimicrobial Peptides[J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(7): 3359-3371.

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Research Progress on Properties, Functions and Optimization Strategies of Antimicrobial Peptides

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