Wip1基因对动物繁殖及免疫的调节作用

doi:10.16431/j.cnki.1671-7236.2022.09.024

Abstract

Abstract: Wild-type p53-induced phosphatase 1(Wip1) is a member of protein phosphatase 2C (PP2C) family, which regulates a number of critical signal molecules, such as p53, MAPK and Chk1/Chk2, and so on, it plays an important role in physiological and pathological processes of cell cycle, proliferation, differentiation, apoptosis, senescence, autophagy and DNA damage repair in animal.With the rapid development of molecular biology, many studies have reported that the deletion of Wip1 gene will imbalance the level of reproductive hormones in mice, and it affects spermatogenesis by regulating signal pathways such as ATM, Wnt, apoptosis and inflammation, resulting in the decrease of animal fecundity.In addition, Wip1 gene also regulates DNA damage response and dephosphorylation through dynamic balance to affect oocyte and embryonic development, so as to regulate the reproduction of female animals.The immune system is an important system in the body to perform immune response and immune function, and it is closely related to tumorigenesis.Knock-out Wip1 gene will also increase the sensitivity to pathogens, affect the migration and apoptosis of T cells, B cells and neutrophils, and lead to inflammation.As a proto-oncogene, Wip1 gene also participates in tumorigenesis by regulating various signal molecules, affecting DNA damage repair, cell cycle progression and apoptosis.Therefore, Wip1 gene plays an important role in biological processes such as animal reproductive regulation and immune inflammation.At present, Wip1 gene has been attracting more and more attention, especially its mechanism of regulating the occurrence and development of animal diseases has become a research hotspot.This study mainly reviewed the regulatory effect of Wip1 gene on animal reproduction and immune, in order to provide new ideas for livestock breeding, disease prevention and targeted therapy

Key words: Wip1 gene; reproductive regulation; immunity; tumorigenesis

CLC Number:

WANG Yue, ZHENG Yunxi, XU Songsong, XIANG Guangming, LI Hua, WANG Nan, FENG Zheng, LI Kui, MU Yulian. Regulation of Wip1 Gene on Animal Reproduction and Immunity[J]. China Animal Husbandry & Veterinary Medicine, 2022, 49(9): 3500-3507.

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Regulation of Wip1 Gene on Animal Reproduction and Immunity

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