前列腺素F2α及其类似物对哺乳动物生殖影响的研究进展

doi:10.16431/j.cnki.1671-7236.2022.08.023

Abstract

Abstract: Prostaglandin F_2α (PGF_2α) is a luteinolytic factor,which is widely used in estrus synchronization and induced parturition in sows.In recent years,new functions of PGF_2α have been found one after another.As a pregnancy recognition signal of mammals,endogenous PGF_2α can bind to PGF_2α receptor (FP) in the fetus and endometrium,initiate downstream signal pathways,and play an important role in early embryonic development,implantation and pregnancy maintenance.Lack or insufficient synthesis will lead to pregnancy interruption or abortion.In view of the promoting effect of PGF_2α on the reproduction activities of female animals,the veterinary drug center has developed a variety of PGF_2α drugs,such as sodium chloroprostol,dinoprostaglandin F_2α and so on,which are widely used to start delivery and promote estrus.According to the optical activity of sodium chloroprostol,it can be divided into D-type and L-type enantiomers,in which D-type structure is the main active component of sodium chloroprostol.Exogenous PGF_2α drugs can not only induce simultaneous estrus and synchronous delivery of sows,promote postpartum health and increase the estrus rate of weaned sows,but also improve sow lactation ability and colostrum quality,improve piglet vitality and other production traits.This paper reviews the research progress of new functions of PGF_2α at home and abroad in recent years,including the dual effects of PGF_2α on periodic corpus luteum,the important effects of PGF_2α on early embryo development,implantation and late pregnancy delivery,as well as the important effects of PGF_2α on sow lactation and piglet vitality.It also summarizes the effects of several PGF_2α and its analogues on reproductive performance of female animals.The purpose of this study is to provide theoretical basis for the rational use of PGF_2α and its analogues.

Key words: prostaglandin F_2α; implantation; delivery; early embryonic development; luteinolysis

CLC Number:

S826.8

ZHU Xuedan, PAN Xueqing, MA Junyan, ZHOU Lele, ZHANG Shouquan. Research Progress on the Effects of Prostaglandin F_2α and Its Analogues on the Reproductive Performance of Mammal[J]. China Animal Husbandry & Veterinary Medicine, 2022, 49(8): 3072-3082.

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Research Progress on the Effects of Prostaglandin F_2α and Its Analogues on the Reproductive Performance of Mammal

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Research Progress on the Effects of Prostaglandin F2α and Its Analogues on the Reproductive Performance of Mammal

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Research Progress on the Effects of Prostaglandin F_2α and Its Analogues on the Reproductive Performance of Mammal