非编码RNA对猪骨骼肌发育的影响

doi:10.16431/j.cnki.1671-7236.2021.10.010

Abstract

Abstract: Skeletal muscle development is closely related to pork yield and quality, which is affected by various factors. In recent years, the influence of non-coding RNA (ncRNA) on skeletal muscle development has become one of the new research hotspot. ncRNA mainly include microRNA (miRNA), long non-coding RNA (lncRNA) and circular RNA (circRNA), which were a class of RNAs that do not have the function of encoding a protein. Initially, they were thought to only regulate gene expression at the transcriptional and post-transcriptional level. However, with the deepening of research, more and more non-coding RNAs have been confirmed to be involved in various biological processes, such as proliferation, differentiation and apoptosis of skeletal muscle cells. In details, miRNAs affect the function of the targeted mRNAs by binding to the complementary sequences of their target mRNA. lncRNA and circRNA can act as molecular sponges of miRNA to weaken the inhibitory effect of miRNA on targets. Therefore, the author mainly reviews ncRNA introduction, and the effects of miRNA, lncRNA and circRNA on the development of porcine skeletal muscle, and put forward the prospect of ncRNA on the growth and development of porcine skeletal muscle.

Key words: ncRNA; pigs; skeletal muscle development; miRNA; lncRNA; circRNA

CLC Number:

Q752

LIN Zekun, ZHUANG Xiaona, LUO Junyi, CHEN Ting, XI Qianyun, ZHANG Yongliang, SUN Jiajie. Effects of Non-coding RNAs on Skeletal Muscle Development in Pigs[J]. China Animal Husbandry & Veterinary Medicine, 2021, 48(10): 3595-3603.

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Effects of Non-coding RNAs on Skeletal Muscle Development in Pigs

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