丁酸钠对肉鸡肠道形态与消化吸收功能影响的研究进展

doi:10.16431/j.cnki.1671-7236.2021.05.011

Abstract

Abstract: The intestine is an important digestive,endocrine and immune organ of broilers,and intestinal health depends on the dynamic balance between nutrients,microbial flora and intestinal mucosa.Intestinal digestion and absorption are directly related to the growth of intestinal epithelial cells and intestinal morphology integrity.As an energy source,sodium butyrate can stimulate intestinal epithelial cell proliferation,and improve intestinal mucosal morphology in broiler and promote villus growth and intestinal tissue development.Through the intestinal free fatty acid receptors FFAR2 and FFAR3,sodium butyrate mediates the secretion of various hormones from intestinal endocrine cells,promotes gastrointestinal mucosa development,and stimulates the secretion of digestive enzymes from the stomach and pancreas,and promote nutrient digestion and absorption.Sodium butyrate is an essential regulator of intestinal homeostasis,which can stimulate mucin production,increase the thickness of mucus layer,reduce the permeability of colonic epithelium,and maintain intestinal integrity and mucosal barrier function.Sodium butyrate promotes the synthesis of host defense peptides (HPDs),inhibits intestinal harmful bacteria's proliferation,and reduces endotoxin's damage to intestinal epithelial cells.By inhibiting NF-κB kinase (IKK),sodium butyrate can down-regulate the pro-inflammatory pathway,inhibit the activation of NF-κB,prevent intestinal mucosal inflammation,promote digestion and absorption,and protect intestinal health.Therefore,sodium butyrate has intestinal protection and antibacterial effect,enhances intestinal integrity,promote digestion and absorption of nutrients and improves immunity and disease resistance.Under the background of the prohibition of antibiotics in the feed industry,it is very important to study and apply sodium butyrate as an antibiotic substitute.The authors focused on the mechanism of the effect of sodium butyrate on intestinal function,in order to provide a scientific basis for the replacement of antibiotics in broiler feed.

Key words: sodium butyrate; broiler; intestinal morphology; digestion and absorption

CLC Number:

S816.7

LI Xiang, HE Jinhuan, PAN Chunmei, SUO Jianghua, LI Jing. Research Progress on Effect of Sodium Butyrate on Intestinal Morphology, Digestion and Absorption Function of Broilers[J]. China Animal Husbandry & Veterinary Medicine, 2021, 48(5): 1603-1612.

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Research Progress on Effect of Sodium Butyrate on Intestinal Morphology, Digestion and Absorption Function of Broilers

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