Abstract: Sleep deprivation has negative effects on both animals' and humans' physical structures and functions.It can lead to multiple diseases,even cause death,especially connect to the body's digestion and metabolism.This article mainly summarizes the effects of sleep deprivation on the structure and function of stomach,intestine,liver and other organs,and focuses on the effects of sleep deprivation on the body's oxidative stress level,cytokine concentration and hormone secretion,and why they may cause digestive system disorders.In addition,food intake also affects the state of sleep deprived animals.The effects of sleep deprivation on the digestive system include damage to the digestive tract mucosa and liver cells,decreased gastric motility,dysbiosis of the gut microbiota,abnormal secretion of gastrointestinal hormones and insulin,etc.,which in turn affects energy metabolism of the body,slows down its recovery from damage,and increases the chance of getting malignant diseases.Sleep deprivation,as a stressor,will significantly increase the body's oxidative stress level,increase the metabolic burden of cells,and do harm to a variety of biological macromolecules,especially DNA.The increased release of cytokines such as TNF-α leads to widespread inflammation,hormone secretion is also a part of the damage process.If the damage continues to develop,it will increase the risk of cancer.Practice has also proved that some foods and drugs can affect sleep deprivation,but the mechanism is still unclear.At present,there are still many unknowns in the mechanism research of sleep deprivation on the digestive system and even the whole body,and there are broad research prospects.

Key words: sleep deprivation; digestive system; oxidative stress