支持细胞对精原干细胞自我更新和分化调控机制研究进展

doi:10.16431/j.cnki.1671-7236.2025.09.002

摘要/Abstract

摘要： 精子发生是哺乳动物生殖过程中的关键环节，精原干细胞(spermatogonial stem cells，SSCs)在这一过程中起着至关重要的作用。睾丸支持细胞(Sertoli cells，SCs)作为精子发生的核心细胞，除了为精原干细胞提供物理支撑和稳定的微环境外，还通过分泌多种细胞因子、信号分子调控精原干细胞的增殖、分化、凋亡和免疫豁免等过程，显著影响精原干细胞的自我更新和分化过程。文章主要对支持细胞通过不同机制调控精原干细胞发育进行综述，旨在为精原干细胞的研究提供新的视角和思路，并推动其在生殖生物学和临床应用领域的发展。

关键词: 支持细胞; 精原干细胞; 自我更新; 分化

Abstract: Spermatogenesis is a critical process in mammalian reproduction,in which spermatogonial stem cells (SSCs) play an indispensable role.As the central cells in spermatogenesis,Sertoli cells (SCs) not only provide physical support and a stable microenvironment for SSCs but also intricately regulate their proliferation,differentiation,apoptosis,and immune privilege by secreting various cytokines and signaling molecules.This complex interplay significantly influences the self-renewal and differentiation of SSCs.This review focuses on the mechanisms by which SCs regulate SSCs development,aiming to offer new perspectives and insights for SSCs research and to advance its applications in reproductive biology and clinical practice.

Key words: Sertoli cells; spermatogonial stem cells; self-renewal; differentiation

中图分类号:

S814.1

朱丽娜, 安雪姣, 岳耀敬. 支持细胞对精原干细胞自我更新和分化调控机制研究进展[J]. 中国畜牧兽医, 2025, 52(9): 4021-4031.

ZHU Lina, AN Xuejiao, YUE Yaojing. Research Progress on the Mechanisms of Sertoli Cell Regulation of Spermatogonial Stem Cell Self-renewal and Differentiation[J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(9): 4021-4031.

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